The Libby Community Childhood Health Investigation and Exposure Follow-Up Study (

利比社区儿童健康调查和暴露后续研究（

• 批准号: 8293173
• 负责人: Brad Black
• 金额: $ 29.65万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8293173
• 关键词: Address; Adult; Advocate; Affect; Age; Air Pollution; Alveolar; Alveolus; Amphibole Asbestos; Amphiboles; Area; Asbestos; Awareness; Birth; California; Canada; Carcinogens; Chest; Child; Child health care; Childhood; Chronic; Climacteric; Clinical; Collection; Communication Programs; Communities; Community Actions; Community Health; Data; Databases; Deposition; Diffuse; Disease; Disease Progression; Education and Outreach; Educational Materials; Employee; Enrollment; Environmental Exposure; Environmental and Occupational Exposure; Epitympanic Recess; Evaluation; Exposure to; Fiber; Geography; Growth and Development function; Health; Health Policy; Health Professional; Health Services Research; Heating; Home environment; Hospitals; Household; Idaho; Individual; Infant; Information Dissemination; Interstitial Lung Diseases; Interview; Investigation; Knowledge; Left; Letters; Life; Location; Lung; Lung Inflammation; Measures; Medical; Medical Research; Mesothelioma; Methods; Minerals; Mining; Montana; Morbidity - disease rate; National Institute of Environmental Health Sciences; Nursing Education; Parents; Participant; Pathway interactions; Personal Communication; Physician Executives; Plants; Play; Pleural; Poison; Population; Predisposition; Preparation; Prevalence; Process; Public Health; Pulmonary function tests; Radial; Recommendation; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Respiratory System; Respiratory physiology; Risk Factors; Rural; Rural Community; Sampling; Scanning; Schools; Screening procedure; Shipping; Ships; Silver; Site; Staging; Symptoms; Test Result; Time; Universities; Update; Vulnerable Populations; Work; aged; airway remodeling; base; cohort; continuing medical education; critical period; disease registry; early childhood; emerging adult; follow-up; frontier; high risk; interest; lung development; lung volume; member; mortality; operation; outreach; outreach program; prevent; programs; pulmonary function; research study; respiratory; rural area; toxicant; tv watching; urban area; vermiculite; wasting; young adult

DESCRIPTION (provided by applicant): Libby MT is an underserved frontier community where vermiculite ore was mined and processed from the 1920s until 1990. This ore was distributed to 245 sites throughout the U.S. and tens of thousands of households used the end-product for insulation and horticulture activities. The Libby vermiculite, referred to as Libby Amphibole (LA), contains asbestos minerals and exposure is associated with pulmonary function loss, pleural and interstitial lung diseases and respiratory mortality. A federal investigation clearly demonstrated that children growing up in Libby as well as all 28 other sites thus far investigated, had numerous pathways of exposure. These pathways included ambient air pollution as well as contamination of homes, schools, playgrounds and manufacturing dump sites near residential areas. LA is attractive to children because of its silver sparkles and ability to pop when heated. Pleural plaques were retrospectively identified in a child as young as nine. Almost no information is available, however, on the children who grew up Libby and other contaminated communities who had on-going childhood environmental exposures. Concern about childhood exposures is amplified by understanding that at birth, infants have completed only 20% of alveolar lung development and have immature clearance mechanisms. As lung growth and development continues until early adulthood, children are likely the most vulnerable group. The Libby community and numerous other contaminated towns are very concerned about their children's health. The Center for Asbestos Related Disease (CARD) has been a medical and educational community based organization serving Libby since 2000 when federal investigations began. CARD is a partner on this study. The three study aims are 1) determine if childhood exposure to LA is associated with a significant increase in adverse pulmonary effects, 2) develop and utilize a comprehensive environmental exposure matrix to characterize childhood exposures and 3) develop, implement and evaluate a well-defined reciprocal outreach and communication program. The Libby young adults have now had a sufficient latency period where effects on their lung development can be measured and actions to prevent or decrease morbidity taken. The impact of this study far exceeds the boundary of Libby, as many other communities also have been contaminated. Further, this study represents one of the clearest examples of widespread contamination resulting in chronic exposure and likely direct adverse impact on the developing lungs of children. PUBLIC HEALTH RELEVANCE: Libby MT is one of many communities with widespread contamination due to mining and milling operations of vermiculite containing asbestos minerals. Children of Libby have had documented chronic exposure due to contamination of their homes, schools and playgrounds. They are a particularly vulnerable population as their lungs are immature at birth and continue to develop until adulthood. This project will work in concert with the Center for Asbestos Related Disease in the Libby community to better understand the health effects on children in that and other contaminated communities.

描述（由申请人提供）：Libby MT 是一个服务不足的边境社区，从 1920 年代到 1990 年，这里一直开采和加工蛭石矿石。这种矿石被分发到美国各地的 245 个地点，数以万计的家庭将最终产品用于隔热和园艺活动。利比蛭石，称为利比角闪石 (LA)，含有石棉矿物质，接触石棉矿物质会导致肺功能丧失、胸膜和间质性肺疾病以及呼吸系统死亡。一项联邦调查清楚地表明，在利比以及迄今为止接受调查的所有其他 28 个地点长大的儿童有多种接触途径。这些途径包括环境空气污染以及住宅区附近的家庭、学校、游乐场和制造垃圾场的污染。洛杉矶对孩子们很有吸引力，因为它闪闪发光，受热后会爆裂。回顾性地在一名九岁的儿童身上发现了胸膜斑块。然而，几乎没有关于在利比和其他受污染社区长大的儿童的信息，这些儿童在童年时期一直暴露在环境中。由于了解婴儿在出生时仅完成了 20% 的肺泡肺发育并且具有不成熟的清除机制，因此对儿童暴露的担忧进一步加剧。由于肺部的生长和发育一直持续到成年早期，因此儿童可能是最脆弱的群体。利比社区和许多其他受污染的城镇非常关心孩子们的健康。自 2000 年联邦调查开始以来，石棉相关疾病中心 (CARD) 一直是一个以医疗和教育社区为基础的组织，为利比提供服务。 CARD 是这项研究的合作伙伴。这三个研究目标是：1) 确定儿童时期接触洛杉矶是否与肺部不良影响显着增加有关；2) 制定和利用全面的环境暴露矩阵来描述儿童接触情况；3) 制定、实施和评估明确的互惠外展和沟通计划。利比年轻人现在已经有了足够的潜伏期，可以测量对其肺部发育的影响，并采取行动预防或减少发病率。这项研究的影响远远超出了利比的范围，因为许多其他社区也受到了污染。此外，这项研究是广泛污染导致长期接触并可能对儿童肺部发育产生直接不利影响的最明显例子之一。 公共卫生相关性：利比 MT 是由于含有石棉矿物的蛭石的采矿和研磨作业而受到广泛污染的许多社区之一。利比的孩子们因家庭、学校和操场受到污染而长期接触病毒。他们是特别脆弱的人群，因为他们的肺部在出生时尚未成熟，并持续发育直至成年。该项目将与利比社区石棉相关疾病中心合作，以更好地了解石棉对该社区和其他受污染社区儿童健康的影响。