The Libby Community Childhood Health Investigation and Exposure Follow-Up Study (

利比社区儿童健康调查和暴露后续研究（

基本信息

批准号：
8293173
负责人：
Brad Black
金额：
$ 29.65万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-17 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8293173
关键词：
Address Adult Advocate Affect Age Air Pollution Alveolar Alveolus Amphibole Asbestos Amphiboles Area Asbestos Awareness Birth California Canada Carcinogens Chest Child Child health care Childhood Chronic Climacteric Clinical Collection Communication Programs Communities Community Actions Community Health Data Databases Deposition Diffuse Disease Disease Progression Education and Outreach Educational Materials Employee Enrollment Environmental Exposure Environmental and Occupational Exposure Epitympanic Recess Evaluation Exposure to Fiber Geography Growth and Development function Health Health Policy Health Professional Health Services Research Heating Home environment Hospitals Household Idaho Individual Infant Information Dissemination Interstitial Lung Diseases Interview Investigation Knowledge Left Letters Life Location Lung Lung Inflammation Measures Medical Medical Research Mesothelioma Methods Minerals Mining Montana Morbidity - disease rate National Institute of Environmental Health Sciences Nursing Education Parents Participant Pathway interactions Personal Communication Physician Executives Plants Play Pleural Poison Population Predisposition Preparation Prevalence Process Public Health Pulmonary function tests Radial Recommendation Recording of previous events Reporting Research Research Personnel Research Project Grants Respiratory System Respiratory physiology Risk Factors Rural Rural Community Sampling Scanning Schools Screening procedure Shipping Ships Silver Site Staging Symptoms Test Result Time Universities Update Vulnerable Populations Work aged airway remodeling base cohort continuing medical education critical period disease registry early childhood emerging adult follow-up frontier high risk interest lung development lung volume member mortality operation outreach outreach program prevent programs pulmonary function research study respiratory rural area toxicant tv watching urban area vermiculite wasting young adult

项目摘要

DESCRIPTION (provided by applicant): Libby MT is an underserved frontier community where vermiculite ore was mined and processed from the 1920s until 1990. This ore was distributed to 245 sites throughout the U.S. and tens of thousands of households used the end-product for insulation and horticulture activities. The Libby vermiculite, referred to as Libby Amphibole (LA), contains asbestos minerals and exposure is associated with pulmonary function loss, pleural and interstitial lung diseases and respiratory mortality. A federal investigation clearly demonstrated that children growing up in Libby as well as all 28 other sites thus far investigated, had numerous pathways of exposure. These pathways included ambient air pollution as well as contamination of homes, schools, playgrounds and manufacturing dump sites near residential areas. LA is attractive to children because of its silver sparkles and ability to pop when heated. Pleural plaques were retrospectively identified in a child as young as nine. Almost no information is available, however, on the children who grew up Libby and other contaminated communities who had on-going childhood environmental exposures. Concern about childhood exposures is amplified by understanding that at birth, infants have completed only 20% of alveolar lung development and have immature clearance mechanisms. As lung growth and development continues until early adulthood, children are likely the most vulnerable group. The Libby community and numerous other contaminated towns are very concerned about their children's health. The Center for Asbestos Related Disease (CARD) has been a medical and educational community based organization serving Libby since 2000 when federal investigations began. CARD is a partner on this study. The three study aims are 1) determine if childhood exposure to LA is associated with a significant increase in adverse pulmonary effects, 2) develop and utilize a comprehensive environmental exposure matrix to characterize childhood exposures and 3) develop, implement and evaluate a well-defined reciprocal outreach and communication program. The Libby young adults have now had a sufficient latency period where effects on their lung development can be measured and actions to prevent or decrease morbidity taken. The impact of this study far exceeds the boundary of Libby, as many other communities also have been contaminated. Further, this study represents one of the clearest examples of widespread contamination resulting in chronic exposure and likely direct adverse impact on the developing lungs of children. PUBLIC HEALTH RELEVANCE: Libby MT is one of many communities with widespread contamination due to mining and milling operations of vermiculite containing asbestos minerals. Children of Libby have had documented chronic exposure due to contamination of their homes, schools and playgrounds. They are a particularly vulnerable population as their lungs are immature at birth and continue to develop until adulthood. This project will work in concert with the Center for Asbestos Related Disease in the Libby community to better understand the health effects on children in that and other contaminated communities.

描述（由申请人提供）：Libby MT是一个服务不足的边境社区，从1920年代到1990年，开采了ver虫矿石和处理。该矿石被分配给美国的245个地点，数万个家庭使用了最终产品的绝缘和养生活动。 Libby Vericulite，称为Libby闪石（LA），含有石棉矿物质，暴露与肺功能丧失，胸膜和间质肺疾病和呼吸道死亡率有关。一项联邦调查清楚地表明，在利比（Libby）以及迄今已调查的其他28个地点的儿童都有许多暴露途径。这些途径包括环境空气污染，以及住宅区附近的房屋，学校，游乐场和制造垃圾场的污染。洛杉矶对儿童有吸引力，因为它的银色火花和加热时弹出的能力。在九岁的孩子中回顾性地发现了胸膜斑块。但是，几乎没有关于长大利比和其他受到童年环境暴露的受污染社区的孩子的信息。通过了解出生时，对童年暴露的关注得到了扩大，即婴儿仅完成肺泡发育的20％，并具有不成熟的清除机制。随着肺部生长和发育一直持续到成年初，儿童可能是最脆弱的群体。利比社区和许多其他受污染的城镇非常关注孩子的健康。自2000年联邦调查开始以来，石棉相关疾病中心（CARD）一直是一个基于医学和教育社区的组织，为利比提供服务。卡是这项研究的合作伙伴。这三个研究的目的是1）确定儿童期暴露于LA是否与不良肺部不良影响的显着增加有关，2）开发和利用全面的环境暴露矩阵来表征儿童期的暴露和3）3）开发，实施和评估一个定义明确的互惠外展和通信计划。现在，利比年轻人已经有足够的潜伏期，可以测量对肺发育的影响，并采取行动以防止或减少发病率。这项研究的影响远远超过了利比的边界，因为许多其他社区也受到污染。此外，这项研究代表了广泛污染的最明显例子之一，导致长期暴露并可能对儿童发育中的肺部进行直接不利影响。公共卫生相关性：Libby MT是许多社区之一，由于含石棉矿物质的ver虫的采矿和铣削操作，众多污染了广泛的污染。利比（Libby）的孩子由于房屋，学校和游乐场的污染而记录了长期暴露。他们是一个特别脆弱的人群，因为他们的肺部出生时不成熟，并继续发展直到成年。该项目将与Libby社区中的石棉相关疾病中心协同合作，以更好地了解对该儿童和其他受污染社区的健康影响。