Project 2: Fate and Effects of Inhaled ENMs in the Lung

纳米材料吸入暴露及其对健康的潜在影响 工程纳米材料(ENM)是一种新兴的材料类别，正在得到越来越多的使用 在成像、电子和治疗领域；然而，它们已经是越来越多的 常用产品，如电脑芯片、化妆品、服装和膳食补充剂。连 尽管这些ENM可能被证明是有益的，但人们对它们的潜力提出了担忧 健康风险。虽然这些粒子在过去的几十年里一直被研究，但直到最近才有 ENMS的潜在毒性已经得到了认真的研究。这个毒性问题是最近才发生的 突出的是7名工厂女工在5-13年的工作中接触纳米颗粒的案例报告 出现肺损伤并伴有肺纤维化和炎症的人^，尽管可能有 还有其他因素牵涉到这些不幸的案件。 可能接触新城疫的人包括工人、消费者和通过 多种途径，包括经皮肤或经胃肠途径或经眼睛，但吸入途径 仍然是潜在的最重要的一个。吸入途径也是许多患者的重要途径 ENMS的应用包括显像剂、基因治疗和治疗药物输送到感染或 肿瘤部位。

Nanomaterial Inhalational Exposure and Potential Health Effects Engineered nanomaterials (ENMs) are an emerging category of materials that are finding increasing use in the areas of imaging, electronics and therapeutics; however, they are already part of a widening number of products that are commonly used such as computer chips, cosmetics, clothing and dietary supplements. Even though these ENMs may prove to be beneficial, there have been concerns raised regarding their potential health risks. Although these particles have been studied for the last few decades, only recently has the potential toxicity of ENMs been researched in a serious way. This issue of toxicity has been recently highlighted by the case report of 7 female factory workers exposed to nanoparticles during their work for 5-13 months who developed lung damage with pulmonary fibrosis and inflammation^, although there may have been other factors involved in these unfortunate cases. People that may be exposed to ENMs include workers, consumers and the general public through a number of ways that include by skin or by the gastrointestinal route or through the eyes, but the inhaled route remains potentially the most important one. The inhaled route is also an important one for a number of applicafions for ENMs including imaging agents, gene therapy and therapeufic drug delivery to infected or tumour sites.