The novel therapeutic approach for emphysema by regeneration of microvessel and alveolus after intrapulmonary arterial administration of gelatin microspheres slowly releasing basic fibroblast growth factor(bFGF-GMS).

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The prognosis of patients with emphysema is poor, and no truly effective treatment is available. Our previous study showed that the alveolar space was smaller and the microvessel density was higher in a canine emphysema model after intrapulmonary arterial administration of gelatin microspheres slowly releasing basic fibroblast growth factor(bFGF-GMS). We evaluated the functional effect of injection of bFGF-GMS via the pulmonary artery in a canine pulmonary emphysema model. Lung compliance in the total emphysema group was higher than in the control group(p=0. 031), and the bFGF group showed no significant improvement of lung compliance in comparison with the total emphysema group(p=0. 112). PaO_2(partial pressure of oxygen in arterial blood) was improved by administration of bFGF-GMS in the total emphysema model(p=0. 027). In the canine total emphysema model, blood gas parameters were improved by whole pulmonary arterial administration of bFGF-GMS. This method has the potential to be an effective novel therapy for pulmonary emphysema.