In home closed loop reduction of nocturnal hypoglycemia and daytime hyperglycemia

在家闭环减少夜间低血糖和日间高血糖

基本信息

批准号：
8538946
负责人：
ROY W. BECK
金额：
$ 73.07万
依托单位：
JAEB CENTER FOR HEALTH RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2016-08-31
项目状态：
已结题

项目摘要

ABSTRACT Two of the major problems in attaining euglycemia in subjects with type 1 diabetes (T1D) are hypoglycemia (including fear of severe hypoglycemia) and post-meal hyperglycemia. The latter commonly occurs in adolescents secondary to missed meal and snack insulin boluses. Both of these issues will be addressed over the five years of this grant. As over half of severe hypoglycemic events occur during sleep, we will continue our development of algorithms to predict and prevent nocturnal hypoglycemia using a closed loop system (CLS) in which the information from a continuous glucose monitor (CGM) is used to suspend delivery of insulin by an insulin pump. Initial studies will be done in the Clinical Translational Research Centers (CTRCs) to document safety of the "Florence" CLS (Abbott Diabetes Care) and we will then conduct a randomized clinical trial in the home environment in years 2 and 3 of the grant. Similarly, a fully portable CLS will be used to detect and correct hyperglycemia resulting from missed food boluses. The safety and efficacy of algorithms which utilize the signal form a CGM and provide output to an insulin pump will initially be studied in the CTRC's in year 3 of the grant. In years 4 and 5 of this grant we plan to assess the combined algorithms for prevention of hypoglycemia and hyperglycemia in a fully ambulatory system developed by Abbott Diabetes Care. We believe that prevention of hypoglycemia, particularly at night, and reduction of post prandial hyperglycemia will result in improvement in glycemic control and reduction in HbA1c levels.

抽象的在患有1型糖尿病（T1D）受试者中达到尤利克血症的两个主要问题是低血糖（包括对严重低血糖症的恐惧）和美食后高血糖。后者通常发生在未经用餐和零食胰岛素大剂量的青少年中发生。两个这些问题将在这笔赠款的五年内解决。超过一半的严重降血糖事件发生在睡眠期间，我们将继续开发算法使用闭环系统（CLS）预测和预防夜间低血糖，其中来自连续葡萄糖监测仪（CGM）的信息用于暂停通过胰岛素泵。初步研究将在临床翻译研究中心进行（CTRC）记录“佛罗伦萨” CLS（雅培糖尿病护理）的安全性，然后我们将赠款的2年级和第3年，在家庭环境中进行随机临床试验。同样，将使用完全便携式CLS来检测和纠正由错过食物大块。使用信号形成CGM的算法的安全性和功效并为胰岛素泵提供输出最初将在CTRC的第3年中研究授予。在这笔赠款的第4和5年中，我们计划评估预防算法的合并算法雅培糖尿病发展的完全门诊系统中低血糖和高血糖关心。我们认为，预防低血糖症，尤其是晚上，并减少邮政 Prandial高血糖将改善血糖控制和HBA1C的减少水平。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Predictive Low-Glucose Insulin Suspension Reduces Duration of Nocturnal Hypoglycemia in Children Without Increasing Ketosis.

DOI：
10.2337/dc14-3053
发表时间：
2015-07
期刊：
Diabetes care
影响因子：
16.2
作者：
Buckingham BA;Raghinaru D;Cameron F;Bequette BW;Chase HP;Maahs DM;Slover R;Wadwa RP;Wilson DM;Ly T;Aye T;Hramiak I;Clarson C;Stein R;Gallego PH;Lum J;Sibayan J;Kollman C;Beck RW;In Home Closed Loop Study Group
通讯作者：
In Home Closed Loop Study Group

A novel method to detect pressure-induced sensor attenuations (PISA) in an artificial pancreas.

DOI：
10.1177/1932296814553267
发表时间：
2014-11-01
期刊：
Journal of diabetes science and technology
影响因子：
5
作者：
Baysal, Nihat;Cameron, Fraser;Bequette, B Wayne
通讯作者：
Bequette, B Wayne

Challenges and Recent Progress in the Development of a Closed-loop Artificial Pancreas.

DOI：
10.1016/j.arcontrol.2012.09.007
发表时间：
2012-12
期刊：
ANNUAL REVIEWS IN CONTROL
影响因子：
9.4
作者：
Bequette, B. Wayne
通讯作者：
Bequette, B. Wayne

Ketone production in children with type 1 diabetes, ages 4-14 years, with and without nocturnal insulin pump suspension.

4-14 岁 1 型糖尿病儿童在有或没有夜间胰岛素泵暂停的情况下的酮产生情况。

DOI：
10.1111/pedi.12410
发表时间：
2017
期刊：
Pediatric diabetes
影响因子：
3.4
作者：
Wadwa,RPaul;Chase,HPeter;Raghinaru,Dan;Buckingham,BruceA;Hramiak,Irene;Maahs,DavidM;Messer,Laurel;Ly,Trang;Aye,Tandy;Clinton,Paula;Kollman,Craig;Beck,RoyW;Lum,John;InHomeClosedLoopStudyGroup
通讯作者：
InHomeClosedLoopStudyGroup