Effects of Yoga on CVD Risk Factors among African Americans: Jackson Heart Study

瑜伽对非裔美国人 CVD 危险因素的影响：杰克逊心脏研究

• 批准号: 8544391
• 负责人: GAILEN D. MARSHALL
• 金额: $ 70.09万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8544391
• 关键词: Adult; African American; Alternative Medicine; Awareness; Blood; Blood Pressure; Cardiovascular Diseases; Cause of Death; Cessation of life; Cholesterol; Clinical Research; Cohort Studies; Crossover Design; Diagnosis; Diastolic blood pressure; Fasting; Fibrinogen; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Goals; Head; Health; Health Services Accessibility; Health behavior; Heart; Heart Diseases; Hemoglobin concentration result; High Density Lipoproteins; Homocysteine; Homocystine; Hybrids; Hypertension; India; Individual; Inflammation; Institutes; Interleukin-6; Intervention; Joints; LDL Cholesterol Lipoproteins; Life Style; Lipids; Measures; Modeling; Nature; Not Hispanic or Latino; Participant; Phase; Positioning Attribute; Poverty; Prevention program; Randomized; Recruitment Activity; Reporting; Research Design; Research Personnel; Risk Factors; Serum; Stress; Stroke; Target Populations; Testing; Time; Traditional Medicine; Triglycerides; Yoga; cardiovascular disorder risk; cost; cost effective; design; health disparity; health related quality of life; heart disease risk; improved; meetings; multidisciplinary; prevent; primary outcome; public health relevance; secondary outcome

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of death in the U.S. and continues to be one of the nation's largest racial health disparity conditions: compared to non-Hispanic whites, African Americans are 30 percent more likely to die from heart disease and 60 percent more likely to die from a stroke. African Americans are also more likely than whites to have risk factors for CVD, such as hypertension and elevated levels of cholesterol, triglycerides, and HbA1c. Clinical studies of the effects of yoga on mitigating CVD risk factors, although small in nature, have demonstrated promising results. The proposed study, which utilizes a randomized, hybrid phase-in/cross- over design, includes 500 adult hypertensive or pre-hypertensive African American participants from the Jackson Heart Study to test the effect of yoga classes three times per week for 12 weeks on CVD risk factors. The three specific aims of the study are to measure the effect yoga can have on (1) risks for CVD, including hypertension, inflammation, and elevated levels of lipids and hemoglobin A1c; (2) perceived levels of stress; and (3) health behaviors and health-related quality of life. Primary outcomes will be changes in participants' systolic and diastolic blood pressure and their levels of CRP, fibrinogen, homocysteine, and interleukin-6. Secondary outcomes will be changes in participants' levels of HbA1c, total cholesterol, LDL, HDL, and fasting triglycerides; their perceived levels of stress; and their reported health behaviors and health-related quality of life. Because of the number of participants and the rigor of the research design, this study will be the first of its kind. The study team is in the fortunate position to be able to recruit and retain a large number of participants because of its longstanding-and remarkably close-relationship through their joint association with the Jackson Heart Study. Results will be disseminated on a large scale to a variety of professional and lay audiences. If the results of the intervention yield statistically significant improvement in individuals' CVD risk factors, the nation will benefit from an easily replicable model that can be used to help reduce CVD risk.

描述（由申请人提供）： 心血管疾病是美国的首要死因，并且仍然是美国最大的种族健康差异状况之一：与非西班牙裔白人相比，非洲裔美国人死于心脏病的可能性高出 30%，死于中风的可能性高出 60%。与白人相比，非裔美国人也更有可能存在 CVD 危险因素，例如高血压以及胆固醇、甘油三酯和 HbA1c 水平升高。关于瑜伽对减轻心血管疾病危险因素影响的临床研究虽然规模较小，但已显示出有希望的结果。这项拟议的研究采用随机、混合分阶段/交叉设计，纳入了来自 Jackson Heart Study 的 500 名成人高血压或高血压前期非裔美国参与者，以测试每周 3 次瑜伽课程，持续 12 周，对 CVD 危险因素的影响。该研究的三个具体目的是衡量瑜伽对以下方面的影响：(1) CVD 风险，包括高血压、炎症以及血脂和血红蛋白 A1c 水平升高； (2) 感知的压力水平； (3) 健康行为和与健康相关的生活质量。主要结果是参与者的收缩压和舒张压以及 CRP、纤维蛋白原、同型半胱氨酸和白细胞介素 6 水平的变化。次要结果是参与者的 HbA1c、总胆固醇、LDL、HDL 和空腹甘油三酯水平的变化；他们感知到的压力水平；以及他们报告的健康行为和与健康相关的生活质量。由于参与者的数量和研究设计的严谨性，这项研究将是同类研究中的首例。该研究团队很幸运能够招募并留住大量参与者，因为他们与杰克逊心脏研究的联合关系具有长期且非常密切的关系。结果将向各种专业和非专业观众大规模传播。如果干预的结果在统计上显着改善了个人的 CVD 风险因素，那么国家将受益于一个易于复制的模型，该模型可用于帮助降低 CVD 风险。