Clinical Hematology Research Career Development Program (K12) at Hopkins

描述(由申请人提供)：本提案寻求继续在约翰霍普金斯医疗机构(JHMI)进行良性血液学和输血医学的临床血液学职业发展计划。良性血液学和输血医学的下一代临床研究人员将需要包括具有技能、态度、早期研究培训和经验的个人，以利用这些学科的快速发展进展。在制定这一计划时，我们将使用现有的研究基础设施，包括致力于良性血液疾病护理和研究的独立的儿科、内科和输血内科血液科，以及我们在约翰·霍普金斯大学医学院和约翰·霍普金斯大学彭博公共卫生学院的临床调查研究生培训计划(GTPCI)。我们的具体目标是：a)继续寻找、招聘、培训和发展富有创造力和成功的临床研究人员，有能力与参与临床研究的多学科团队互动、参与和领导多学科团队，解决复杂问题，并成为儿科、青少年和成人良性血液和输血医学的国家领导者；b)为学员提供在这些领域的临床研究成功的学术生涯所需的技能、知识、态度和经验。这项培训将包括接触国家和国际领导人以及成功的临床研究所必需的多学科课程，包括良性血液学、输血医学、临床试验设计、流行病学、统计学、研究伦理和人体受试者保护；c) 提供丰富的辅导环境。我们将整合JHMI现有的多种研究资源和研究人员，为学员提供最佳的研究经验和培训机会。我们将继续将我们的努力集中在我们机构内部有特殊优势的六个领域：骨髓衰竭和干细胞生物学、镰刀病(SCD)、骨髓增殖性疾病、输血医学、结果研究和遗传学。我们将与几位成熟的研究人员和导师合作，为学员开发良性血液学的结构化课程和强大的指导性研究经验。仔细和广泛的指导将是这些努力的基石，并接触到尖端研究经验。通过这项计划，我们的最终目标是提供一支临床研究人员队伍，他们将成为创造性的、独立的研究人员，照顾患者，并在良性临床血液学领域担任领导角色。

DESCRIPTION (provided by applicant): This proposal seeks to continue a Clinical Hematology Career Development Program in benign hematology and transfusion medicine at the Johns Hopkins Medical Institutions (JHMI). The next generation of clinical researchers in benign hematology and transfusion medicine will need to include individuals with the skills, attitudes, early research training and experience to capitalize on rapidly developing progress in these disciplines. In developing this program, we will use established research infrastructure, including free-standing Divisions of Hematology in Pediatrics, Internal Medicine and Transfusion Medicine that are dedicated to the care and study of benign hematologic disorders, as well as our Graduate Training Program in Clinical Investigation (GTPCI) at the Johns Hopkins University School of Medicine and Johns Hopkins University Bloomberg School of Public Health. Our specific aims are: a) To continue to identify, recruit, train and develop creative and successful clinical investigators, with the capability to interact with, participate in, and lead multidisciplinary teams involved in clinical research, address complex problems and become national leaders in pediatric, adolescent and adult benign hematology and transfusion medicine; b) To provide trainees with the requisite skills, knowledge, attitude and experience for successful academic careers in clinical research in these areas. This training will include exposure to national and international leaders and curriculum in the multiple disciplines necessary for successful clinical research, including benign hematology, transfusion medicine, clinical trials design, epidemiology, statistics, research ethics and human subjects protection; c) To provide a rich mentoring environment. We will integrate multiple research resources and investigators available at the JHMI to provide optimal exposure of trainees to research experiences and training. We will continue to focus our efforts in six areas where we feel there is particular strength within our institution: bone marrow failure and stem cell biology, sickle cel disease (SCD), myeloproliferative disorders, transfusion medicine, outcomes research and genetics. We will work with several established investigators and mentors to develop a structured curriculum in benign hematology and strong mentored research experiences for trainees. Careful and extensive mentoring will be the cornerstone of these efforts, with exposure to cutting edge research experiences. Through this program, we ultimately aim to provide a cadre of clinical researchers, who will become creative, independent investigators, care for patients and assume leadership roles in benign clinical hematology.