Gamma delta T cells specific for glycolipid antigens

糖脂抗原特异的 γ δ T 细胞

• 批准号: DP140100977
• 负责人: Prof Dale Godfrey
• 金额: $ 27.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100977
• 关键词: Gamma; delta; cells; specific; glycolipid

Gamma delta T cells are an enigmatic component of the immune system that use a unique class of cell surface receptors (gamma delta T cell receptors). Despite having been discovered 30 years ago, very little is known about what these cells recognise and respond to, and therefore what is their function. A population of gamma delta T cells that respond via their T cell receptor to particular forms of lipid molecules presented by an antigen presenting molecule, CD1d has been identified. The aim of this project is to isolate these T cell receptors and investigate the interaction at the molecular level in order to understand the parameters that trigger activation of these cells. This will provide fundamental insight into a key component of the immune system.

γ δ T细胞是免疫系统中一个神秘的组成部分，它使用一类独特的细胞表面受体（γ δ T细胞受体）。尽管这些细胞在30年前就被发现了，但人们对这些细胞的识别和反应，以及它们的功能知之甚少。一群γ δ T细胞通过它们的T细胞受体对抗原呈递分子CD1d呈递的特定形式的脂质分子作出反应。该项目的目的是分离这些T细胞受体，并在分子水平上研究相互作用，以了解触发这些细胞激活的参数。这将为免疫系统的关键组成部分提供基本的见解。