CD1C-LIPID-REACTIVE T CELLS

CD1C-脂质反应性 T 细胞

• 批准号: DP210103064
• 负责人: Prof Dale Godfrey
• 金额: $ 34.38万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103064
• 关键词: CD1C; LIPID; REACTIVE; CELLS

The immune system patrols our body examining molecules such as proteins and lipids that signal whether or not everything is ok. While protein recognition by the immune system is well understood, our knowledge of the fundamental features of lipid detection is poor. This project will investigate the detection of lipid molecules that are presented to the immune system in association with a molecule known as CD1c. The aims are to understand: 1. The cells that respond to these lipids; 2. The cellular receptors that bind to these lipids; 3. The types of lipids involved in this process. This work is essential for us to understand lipid-based immunology which is critical if we ultimately wish to harness this to improve human health.

免疫系统在我们的身体中巡逻，检查蛋白质和脂质等分子，这些分子发出信号，表明一切是否正常。虽然免疫系统对蛋白质的识别已经很好地理解，但我们对脂质检测的基本特征的了解却很差。该项目将研究脂质分子的检测，这些脂质分子与一种称为CD 1c的分子一起呈递给免疫系统。目的是了解：1。对这些脂质作出反应的细胞; 2.与这些脂质结合的细胞受体; 3.参与这一过程的脂质类型。这项工作对于我们了解基于脂质的免疫学至关重要，如果我们最终希望利用它来改善人类健康，这是至关重要的。