Neurobehavioral Analysis Core

神经行为分析核心

• 批准号: 8659020
• 负责人: TONY J SIMON
• 金额: $ 13.07万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8659020
• 关键词: Address; Adult; Autistic Disorder; Behavior; Behavior assessment; Behavioral; Bioinformatics; Biological; Biometry; Blood; Characteristics; Child; Clinical Research; Clinical Trials; Cognition; Cognitive; Communities; Competence; Complex; Consultations; Data; Development; Down Syndrome; Electrophysiology (science); Emotions; Ensure; Environment; Evaluation; Experimental Designs; Eye; Faculty; Fragile X Syndrome; Genetic; Genets; Human; Individual; Infant; Institutes; Label; Laboratories; Language; MRI Scans; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mental Retardation and Developmental Disabilities Research Centers; Methods; Monitor; Neurobiology; Neurodevelopmental Disorder; Other Genetics; Outcome Measure; Parents; Participant; Peer Review; Pharmacological Treatment; Phase; Phenotype; Physiological; Population; Preparation; Process; Production; Protocol Compliance; Protocols documentation; Psychometrics; Psychophysiology; Publications; Recruitment Activity; Research; Research Design; Research Personnel; Sampling; Scanning; School-Age Population; Scientist; Services; Site; Structure; Syndrome; System; Technology; Testing; Time; Training; Translating; Trisomy X syndrome; Work; biobehavior; brain behavior; computerized data processing; control trial; design; evidence base; experience; instrument; intellectual and developmental disability; interest; member; neurobehavioral; neuropsychological; phenome; programs; relating to nervous system; research study; social; treatment trial; visual process; visual processing

The primary objective of the UC Davis MIND Institute IDDRC Neurobehavioral Analysis Core (NAC) is to help investigators generate detailed phenotypic characterizations of individuals with Intellectual and Developmental Disabilities (IDD). Phenotypic characterization requires measures that are appropriate for a representative sample of individuals with IDD and are designed, executed, and analyzed with the most precision and fidelity possible. Existing standardized tests, rating scales, and checklists are often not adequate for such characterization and adaptations of such measures or the creation of new measures are required. Moreover, many measures are often applicable to only a very narrow segment of the IDD population of interest. The NAC will assist IDDRC investigators in ensuring that they have the measures needed to generate advanced biobehavioral characterizations that can stand alone, be used to assess environmental contributions to IDD, or provide the evidence base for the development and evaluation of targeted treatments for IDD. To achieve this objective, the NAC will draw on the interdisciplinary expertise and already developed measures of several MIND Institute and UC Davis faculty and staff to provide key services for investigators conducting neurobiological studies of cognition, emotion, language, and other aspects of brain and behavior in human research participants with neurodevelopmental disorders that create IDD.

加州大学戴维斯分校MIND研究所IDDRC神经行为分析核心（NAC）的主要目标是 帮助研究人员生成具有智力和 发展性残疾（IDD）。表型表征需要适当的措施， IDD个体的代表性样本，并设计，执行和分析最 精确度和保真度。现有的标准化测试、评定量表和检查表往往是不够的 为此，需要对这些措施进行定性和调整，或制定新的措施。 此外，许多措施往往只适用于极少数缺碘症患者， 兴趣NAC将协助IDDRC调查人员确保他们采取必要措施， 先进的生物行为特征，可以独立，用于评估环境贡献 或为开发和评价IDD的靶向治疗提供证据基础。到 为了实现这一目标，国家行动委员会将利用跨学科的专业知识和已经制定的措施， 几个MIND研究所和加州大学戴维斯分校的教职员工提供关键服务，为调查人员进行 神经生物学研究人类的认知、情感、语言以及大脑和行为的其他方面 患有神经发育障碍导致IDD的研究参与者。