Center for Reproductive Health After Disease

病后生殖健康中心

• 批准号: 8498720
• 负责人: Teresa K Woodruff
• 金额: $ 155万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8498720
• 关键词: Address; Affect; Age; Basic Science; Biological Preservation; Biology; Cancer Patient; Cancer Survivor; Caring; Clinical Research; Community Outreach; Decision Making; Diagnosis; Disease; Endocrine; Ensure; Family; Fertility; Functional disorder; Future; Goals; Growth; Health; Health Personnel; Human; Infertility; Intervention; Lead; Life; Life Expectancy; Malignant - descriptor; Malignant Neoplasms; Medical; Newly Diagnosed; Non-Malignant; Oocytes; Ovarian; Ovarian Follicle; Ovarian Tissue; Patients; Pharmaceutical Preparations; Physicians; Problem Solving; Procedures; Process; Provider; Quality of life; Radiation; Reproductive Health; Research; Research Personnel; Risk; Techniques; Testing; Tissue Banking; Tissue Banks; Tissues; Training Support; Treatment Protocols; Universities; Woman; Women' s Health; Work; base; bone; cancer therapy; chemotherapy; compliance behavior; design; disorder risk; effective therapy; egg; gonad function; in vivo; men; next generation; older women; radiation effect; reproductive; reproductive function; tool; young woman

DESCRIPTION (provided by applicant): Cancer is now a disease with a number of highly effective treatment options that are leading to a greater number of cancer survivors who are living long and productive lives. Globally, there are 10 million people diagnosed with cancer, and 10% of newly diagnosed men and women are under the age of 40 years. While aggressive radiation and chemotherapies are able to save and prolong their lives, disruption of reproductive function-including fertility and endocrine function-can be an unintended consequence that is particularly relevant for these young cancer patients. We have also come to recognize that many young women have non-malignant conditions or must undergo treatment with drugs or procedures that can damage their reproductive function. The proposed Northwestern University Center for Reproductive Health After Disease will therefore extend the overall scope of work to ensure that these women are provided options for protecting their reproductive health and that providers are aware of the threat posed by specific diseases and treatments on reproductive function. Moreover, our Center will not be limited to the preservation of fertility but will also address the long-term endocrine health of women who lose gonadal function. There are 20,000 women between the ages of 41 and 51 who are diagnosed with cancer each year, and while these women lie outside the age limit for experimental fertility interventions, they are in need of alternatives that will preserve ovarian endocrine support of various tissues, such as bone. The overall hypothesis of the Center is that effective options can be provided to young women with malignant or non-malignant disease who must undergo life-preserving cancer treatments and other medical interventions that will affect their reproductive health. By assembling a diverse, cross-disciplinary team of investigators, the Center will pursue both basic scientific research and clinical research goals, as well as create and implement educational and community outreach initiatives to share the Center's findings with providers, patients, their families, and the public Center researchers will investigate new techniques for producing healthy, mature oocytes from the pool of immature oocytes in ovarian tissue banked by young cancer patients. Another project will examine the cellular mechanisms that might be targeted to protect eggs from the damaging effects of radiation and chemotherapy; this work will be particularly important for preserving endocrine health in older women. Clinical research will be conducted to determine to what extent fertility concerns affect the medical decision making process of patients. With an expanded scope, a team-based approach to problem solving, and the goal of preserving not only fertility, but all aspects of reproductive health, our Center has the potential to impact the lives of many young women who are at risk of disease-related or iatrogenic infertility and endocrine dysfunction.

描述（由申请人提供）：癌症现在是一种疾病，有许多非常有效的治疗方案，导致更多的癌症幸存者谁是长寿和富有成效的生活。在全球范围内，有1000万人被诊断患有癌症，10%的新诊断男性和女性年龄在40岁以下。虽然积极的放疗和化疗能够挽救和延长他们的生命，但生殖功能（包括生育能力和内分泌功能）的破坏可能是一个意想不到的后果，特别是对这些年轻的癌症患者。我们还认识到，许多年轻妇女患有非恶性疾病，或必须接受可能损害其生殖功能的药物或程序治疗。因此，拟议的西北大学疾病后生殖健康中心将扩大工作的总体范围，以确保这些妇女获得保护其生殖健康的选择，并确保提供者意识到特定疾病和治疗对生殖功能构成的威胁。此外，我们的中心将不仅限于保持生育能力，还将解决失去性腺功能的妇女的长期内分泌健康问题。每年有20，000名年龄在41岁至51岁之间的妇女被诊断患有癌症，虽然这些妇女处于实验性生育干预的年龄限制之外，但他们需要 替代品，将保留卵巢内分泌支持的各种组织，如骨。该中心的总体假设是，可以为患有恶性或非恶性疾病的年轻妇女提供有效的选择，这些妇女必须接受维持生命的癌症治疗和其他将影响其生殖健康的医疗干预。通过组建一支多元化、跨学科的研究团队，该中心将开展基础科研， 临床研究目标，以及创建和实施教育和社区外展计划，与提供者、患者、其家人和公众分享中心的发现 中心的研究人员将研究从年轻癌症患者卵巢组织中储存的未成熟卵母细胞中生产健康成熟卵母细胞的新技术。另一个项目将研究可能有针对性的细胞机制，以保护卵子免受辐射和化疗的破坏性影响;这项工作对保护老年妇女的内分泌健康特别重要。将进行临床研究，以确定生育问题在多大程度上影响患者的医疗决策过程。随着范围的扩大，以团队为基础的方法来解决问题，并保持不仅生育的目标，但生殖健康的各个方面，我们的中心有可能影响许多年轻女性的生活谁是在疾病相关或医源性不孕症和内分泌功能障碍的风险。

项目成果

Virtual High-Throughput Screening To Identify Novel Activin Antagonists.

虚拟高通量筛选以鉴定新型激活素拮抗剂。

• DOI: 10.1021/acs.jmedchem.5b00753
• 发表时间: 2015
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Zhu,Jie;Mishra,RamaK;Schiltz,GaryE;Makanji,Yogeshwar;Scheidt,KarlA;Mazar,AndrewP;Woodruff,TeresaK
• 通讯作者: Woodruff,TeresaK

In vitro development of secondary follicles from pre-pubertal and adult goats cultured in two-dimensional or three-dimensional systems.

• DOI: 10.1017/s0967199414000070
• 发表时间: 2015-08
• 期刊: Zygote (Cambridge, England)
• 作者: Silva GM;Rossetto R;Chaves RN;Duarte AB;Araújo VR;Feltrin C;Bernuci MP;Anselmo-Franci JA;Xu M;Woodruff TK;Campello CC;Figueiredo JR
• 通讯作者: Figueiredo JR

Fertility preservation in women with cancer.

• DOI: 10.1016/s0140-6736(14)60834-5
• 发表时间: 2014-10-04
• 期刊: LANCET
• 影响因子: 168.9
• 作者: De Vos, Michel;Smitz, Johan;Woodruff, Teresa K.
• 通讯作者: Woodruff, Teresa K.

Primordial Follicle Transplantation within Designer Biomaterial Grafts Produce Live Births in a Mouse Infertility Model.

• DOI: 10.1038/srep17709
• 发表时间: 2015-12-03
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Kniazeva E;Hardy AN;Boukaidi SA;Woodruff TK;Jeruss JS;Shea LD
• 通讯作者: Shea LD