Reproductive Biology and Genomics Training Program

描述（由申请人提供）：该计划更新的总体目标是继续提供生殖科学的全面和深入的研究培训，集中整合功能哺乳动物基因组学/遗传学和计算生物学工具的培训。为了实现这一目标，一组精选的研究生和博士后学员将有机会选择并接受双导师的培训;主要培训师具有生殖科学方面的专业知识，联合培训师具有基因组学和/或计算方面的专业知识生物学。十八（18）教师培训代表在此应用程序。我们正在请求支持两（2）学士学位博士学位插槽和三（3）博士后插槽（其中一个是为MD/DVM-Seeking-PhD实习生保留的），每个为期两年的培训间隔。本培训计划要求提供总共五（5）年的支持。这项拟议培训计划的基本思想是，生殖科学的生物医学研究人员将大大受益于实际和应用全基因组调查技术的平行培训。康奈尔大学为生殖科学培训计划做好了独特的准备，该计划涵盖男性和女性生理学，生育的遗传基础，母胎界面生理学，细胞信号传导和分子内分泌学以及生殖癌症的分子和遗传基础。此外，建议的计划将大大受益于包括教师的利益在非哺乳动物模型的复制在果蝇和C。elegans以促进比较进化研究。基因组学和计算领域的培训将强调以下内容（一些例子）：转基因和基因敲除模型的创建和使用（用于生育力研究的动物模型以及强调生殖肿瘤的疾病病理生理学模型）;微阵列和生物信息学分析的使用，包括模式生物和基因组浏览器数据库操作方面的综合培训;有助于确定基因型/表型关系的门户网站;创建基于计算机的建模，以促进对结构/功能关系的知情决策;基于比较基因组学原理的应用的基因转录网络分析。参与这项拟议计划的教师致力于促进生殖科学及其与基因组结构和活动的接口的培训环境。培训师和共同培训师之间的合作是本计划的基石。这种独特的科学和技术界面将增加博士前和博士后学员离开这个环境的机会，在生殖科学和基因组学的多种最先进的技术和应用方面得到良好的培训，这将优化他们在继续培训（过渡到博士后）或 在学术界、政府或工业界获得科学职位。

DESCRIPTION (provided by applicant): The overall goal of the renewal of this Program is to continue to provide comprehensive and in-depth research training in the reproductive sciences, centrally integrating training in the tools of functional mammalian genomics/genetics and computational biology. To accomplish this goal, a select group of graduate and postdoctoral trainees will have the opportunity to choose and be trained by dual mentors; the primary Trainer having expertise in the reproductive sciences and the Co-Trainer with expertise in genomics and/or computational biology. Eighteen (18) faculty trainers are represented in this application. We are requesting support for two (2) baccalaureate PhD slots and three (3) postdoctoral slots (one of which is reserved for a MD/DVM-Seeking-PhD trainee), each for a two-year training interval. Support is requested for a total of five (5) years for this training program. The philosophy behind this proposed training plan is based upon the appreciation that biomedical researchers in the reproductive sciences would benefit greatly from parallel training in practical and applied use of genome-wide investigative techniques. Cornell University is uniquely poised for a training program in reproductive sciences that spans male and female physiology, the genetic bases of fertility, physiology of the maternal-fetal interface, cell signaling and molecula endocrinology and the molecular and genetic basis for reproductive cancers. In addition, the proposed program will benefit greatly by inclusion of faculty members with interests in non-mammalian models of reproduction in Drosophila and C. elegans to facilitate comparative evolutionary studies. Training in the genomics and computational areas will emphasize the following (some examples): creation and use of transgenic and knockout models (animal models for the study of fertility as well as models of disease pathophysiology emphasizing reproductive neoplasia); use of micro arrays and bioinformatics analyses including comprehensive training in manipulation of databases for model organisms and genomic browsers/portals that serve to aid in determination of genotype/phenotype relationships; creation of computer-based modeling to facilitate informed decisions on structure/function relationships; analysis of gene transcription networks based upon application of principles of comparative genomics. The faculty involved in this proposed Program is committed to facilitating a training environment in the reproductive sciences and its interface with genome structure and activity. The collaborative effort(s) between Trainers and coTrainers is the cornerstone of this program. This unique scientific and technical interface will enhance the opportunity for pre- and postdoctoral trainees to leave this environment well-trained in the reproductive sciences and in multiple state-of-the-art techniques and applications in genomics that will optimize their continued success in continued training (transitioning to postdoctoral) or the acquisition of scientific positions in academia, government or industry.