Reproductive Sciences and Genomics Training Program

项目描述（由申请人提供）：该计划的总体目标是提供以功能哺乳动物基因组学和遗传学工具为中心的全面深入的生殖科学研究培训。为了实现这一目标，将有一批研究生和博士后学员有机会选择并接受双导师的培训；具有生殖科学专业知识的初级培训师和具有基因组学专业知识的联合培训师。在此应用程序中有19个教员培训师。我们要求提供三个学士学位博士学位和两个博士后学位，每个学位的培养间隔为2年。这项新的培训计划总共需要5年的支持。这项拟议的培训计划背后的理念是基于这样一种认识，即生殖科学领域的生物医学研究人员将从全基因组调查技术的实际和应用方面的平行培训中受益匪浅。康奈尔大学在生殖科学方面的培训项目是独一无二的，该项目涵盖了男性和女性生理学、生育能力的遗传基础、母胎界面的免疫学基础、细胞信号和分子内分泌学以及生殖癌症的分子和遗传基础。此外，该计划将极大地受益于包括对果蝇和秀丽隐杆线虫的非哺乳动物繁殖模式感兴趣的教员，以促进比较进化研究。基因组学领域的培训将强调以下方面（一些例子）：创建和使用转基因和基因敲除模型（研究生育力的动物模型以及强调生殖肿瘤的疾病病理生理学模型）；使用微阵列和生物信息学分析，包括对模式生物和基因组浏览器/门户数据库操作的全面培训，以帮助确定基因型/表型关系；创建基于计算机的模型，以促进对结构/功能关系的明智决策；基于比较基因组学原理的基因转录网络分析。参与该计划的教师致力于促进生殖科学及其与基因组结构和活动的界面的培训环境。培训师和联合培训师之间的协作努力是本项目的基石。这种独特的科学和技术界面将增加pre- and - postdoctoral受研者离开这个环境的机会，他们在生殖科学和基因组学的多种最先进的技术和应用方面受过良好的训练，这将优化他们在继续培训（过渡到博士后）或在学术界，政府或行业获得科学职位的持续成功。

DESCRIPTION (provided by applicant): The overall goal of the proposed Program is to provide comprehensive and in-depth research training in the reproductive sciences centrally integrating training in the tools of functional mammalian genomics and genetics. To accomplish this goal, a select group of graduate and postdoctoral trainees will have the opportunity to choose and be trained by dual mentors; the primary trainer having expertise in the reproductive sciences and the co-trainer with expertise in genomics. Nineteen faculty trainers are represented in this application. We are requesting support for three baccalaureate Ph.D. slots and two postdoctoral slots, each for a 2 year training interval. Support is requested for a total of 5 years for this new Training Program. The philosophy behind this proposed training plan is based upon the appreciation that biomedical researchers in the reproductive sciences would benefit greatly from parallel training in practical and applied use of genome-wide investigative techniques. Cornell University is uniquely poised for a training program in reproductive sciences that spans male and female physiology, the genetic bases of fertility, the immunological basis of the maternal-fetal interface, cell signaling and molecular endocrinology and the molecular and genetic basis for reproductive cancers. In addition, the proposed Program will benefit greatly by inclusion of faculty members with interests in non-mammalian models of reproduction in Drosophila and C. elegans to facilitate comparative evolutionary studies. Training in the genomics area will emphasize the following (some examples): creation and use of transgenic and knock out models (animal models for the study of fertility as well as models of disease pathophysiology emphasizing reproductive neoplasia); use of micro arrays and bioinformatics analyses including comprehensive training in manipulation of databases for model organisms and genomic browsers/portals that serve to aid in determination of genotype/phenotype relationships; creation of computer-based modeling to facilitate informed decisions on structure/function relationships; analysis of gene transcription networks based upon application of principles of comparative genomics. The faculty members involved in this proposed Program are committed to facilitating a training environment in the reproductive sciences and its interface with genome structure and activity. The collaborative effort(s) between trainers and co-trainers is the cornerstone of this Program. This unique scientific and technical interface will enhance the opportunity for pre- and postdoctoral trainees to leave this environment well-trained in the reproductive sciences and in multiple state-of-the-art techniques and applications in genomics that will optimize their continued success in continued training (transitioning to postdoctoral) or the acquisition of scientific positions in academia, government or industry.