Reproductive Sciences and Genomics Training Program

描述（由申请人提供）：拟议计划的总体目标是提供生殖科学的全面和深入的研究培训，集中整合功能性哺乳动物基因组学和遗传学工具的培训。为了实现这一目标，一组经过挑选的研究生和博士后学员将有机会选择并接受双导师的培训;初级培训师具有生殖科学方面的专业知识，共同培训师具有基因组学方面的专业知识。本申请书中有19名教员培训员。我们请求支持三个学士学位博士。两个博士后名额，每个名额为期2年。这项新的培训方案需要总共5年的支助。这项拟议培训计划的基本思想是，生殖科学的生物医学研究人员将大大受益于实际和应用全基因组调查技术的平行培训。康奈尔大学是唯一准备在生殖科学的培训计划，跨越男性和女性生理学，生育的遗传基础，母胎界面的免疫基础，细胞信号和分子内分泌学和生殖癌症的分子和遗传基础。此外，建议的计划将受益匪浅，包括教师的利益在非哺乳动物模型的复制在果蝇和C。elegans以促进比较进化研究。基因组学领域的培训将强调以下方面（一些例子）：转基因和敲除模型的创建和使用（用于生育力研究的动物模型以及强调生殖肿瘤的疾病病理生理学模型）;使用微阵列和生物信息学分析，包括模型生物数据库操作的全面培训和有助于确定基因型/表型关系;创建基于计算机的建模，以促进结构/功能关系的知情决策;基于比较基因组学原理的应用的基因转录网络分析。参与该计划的教师致力于促进生殖科学及其与基因组结构和活动的接口的培训环境。培训师和共同培训师之间的合作努力是本计划的基石。这种独特的科学和技术接口将提高前和博士后学员离开这个环境训练有素的生殖科学和多种国家的最先进的技术和基因组学的应用，将优化他们在继续培训（过渡到博士后）或在学术界，政府或行业的科学职位收购的持续成功的机会。

DESCRIPTION (provided by applicant): The overall goal of the proposed Program is to provide comprehensive and in-depth research training in the reproductive sciences centrally integrating training in the tools of functional mammalian genomics and genetics. To accomplish this goal, a select group of graduate and postdoctoral trainees will have the opportunity to choose and be trained by dual mentors; the primary trainer having expertise in the reproductive sciences and the co-trainer with expertise in genomics. Nineteen faculty trainers are represented in this application. We are requesting support for three baccalaureate Ph.D. slots and two postdoctoral slots, each for a 2 year training interval. Support is requested for a total of 5 years for this new Training Program. The philosophy behind this proposed training plan is based upon the appreciation that biomedical researchers in the reproductive sciences would benefit greatly from parallel training in practical and applied use of genome-wide investigative techniques. Cornell University is uniquely poised for a training program in reproductive sciences that spans male and female physiology, the genetic bases of fertility, the immunological basis of the maternal-fetal interface, cell signaling and molecular endocrinology and the molecular and genetic basis for reproductive cancers. In addition, the proposed Program will benefit greatly by inclusion of faculty members with interests in non-mammalian models of reproduction in Drosophila and C. elegans to facilitate comparative evolutionary studies. Training in the genomics area will emphasize the following (some examples): creation and use of transgenic and knock out models (animal models for the study of fertility as well as models of disease pathophysiology emphasizing reproductive neoplasia); use of micro arrays and bioinformatics analyses including comprehensive training in manipulation of databases for model organisms and genomic browsers/portals that serve to aid in determination of genotype/phenotype relationships; creation of computer-based modeling to facilitate informed decisions on structure/function relationships; analysis of gene transcription networks based upon application of principles of comparative genomics. The faculty members involved in this proposed Program are committed to facilitating a training environment in the reproductive sciences and its interface with genome structure and activity. The collaborative effort(s) between trainers and co-trainers is the cornerstone of this Program. This unique scientific and technical interface will enhance the opportunity for pre- and postdoctoral trainees to leave this environment well-trained in the reproductive sciences and in multiple state-of-the-art techniques and applications in genomics that will optimize their continued success in continued training (transitioning to postdoctoral) or the acquisition of scientific positions in academia, government or industry.