MODULATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY
MODULATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY
批准号:
8460517
负责人:
CHARLES F ZORUMSKI
金额:
$38.66万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-04-01 至 2015-04-30
关键词:
AMPA ReceptorsAdverse effectsAgonistAmmoniaAreaBiologyBrainCalcineurinCalciumCholesterolCognitionCognitiveDefectDiseaseDistalEmotionsEventExposure toFunctional disorderGlucoseGoalsHippocampus (Brain)HypoxiaIndividualLaboratoriesLearningLightLinkLong-Term DepressionLong-Term PotentiationMediatingMemoryMental disordersMetabolicMitochondriaMotivationN-Methyl-D-Aspartate ReceptorsN-MethylaspartateNerve DegenerationNeuronal InjuryNeuronsNitric Oxide SynthasePatternPhysiologicalPlayProductionPsyche structureRattusReceptor ActivationRoleSecond Messenger SystemsSignal TransductionSliceSteroidsSynapsesSynaptic plasticitySystemTestingTextWorkbasegamma-Aminobutyric Acidhippocampal pyramidal neuronhuman MAPK10 proteininformation processinginnovationmemory processmitogen-activated protein kinase p38neural circuitneuropsychiatryneurosteroidsnovelnovel strategiesreceptor functionresponsestressorsynaptic functiontransmission process
中文摘要
描述(由申请人提供):n -甲基- d -天冬氨酸受体(NMDARs)在信息处理和突触可塑性中发挥关键作用,突触可塑性是学习和认知的基础
英文摘要
DESCRIPTION (provided by applicant): N-methyl-D-aspartate receptors (NMDARs) play critical roles in information processing and in the synaptic plasticity that underlies learning and
memory. Depending upon the pattern of activation, NMDARs can promote long-term potentiation (LTP) or long-term synaptic depression (LTD), two leading candidates for synaptic memory mechanisms. When activated excessively, however, NMDARs can also cause several forms of neurodegeneration. We have observed that there are also conditions in which NMDAR activation produces no change in synaptic responses or neuronal injury, but impairs the ability to generate LTP. This NMDAR-mediated LTP inhibition is observed with low level activation of NMDARs, certain patterns of synaptic stimulation and exposure to sub-lethal stressful conditions (brief hypoxia and low glucose). Because of the role that synaptic plasticity plays in memory processing, this NMDAR-mediated LTP inhibition may be important for understanding the cognitive defects that accompany untimely NMDAR activation in neuropsychiatric disorders. In recent studies, we found that low level NMDAR activation promotes the production of GABA-enhancing neurosteroids in hippocampal pyramidal neurons and these neurosteroids play a key role in LTP inhibition. In this proposal, we will extend our work on NMDAR LTP inhibition by pursuing three aims: 1. To determine conditions under which NMDAR activation promotes neurosteroid production and how steroids contribute to LTP modulation; 2. To determine signaling mechanisms underlying NMDAR-induced neurosteroid production; and 3. To determine the effects of NMDA and neurosteroids on GABAergic inhibition and the mechanisms underlying these effects. These studies will be conducted in the CA1 region of rat hippocampal slices, an area known to be important for memory processing. Our long-term goal is to identify ways to preserve and restore synaptic function in individuals with neuropsychiatric illnesses.
期刊论文(23)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.4172/neuropsychiatry.1000356
发表时间:
2018-01-01
期刊:
Neuropsychiatry
影响因子:
--
作者:
[Ishikawa, Makoto, Yoshitomi, Takeshi, Izumi, Yukitoshi]
通讯作者:
Izumi, Yukitoshi
DOI:
10.1016/j.neulet.2010.04.078
发表时间:
2010-07-12
期刊:
Neuroscience letters
影响因子:
2.5
作者:
[Izumi Y, Zorumski CF]
通讯作者:
Zorumski CF
DOI:
10.1371/journal.pone.0066024
发表时间:
2013
期刊:
PloS one
影响因子:
3.7
作者:
[Wozniak DF, Diggs-Andrews KA, Conyers S, Yuede CM, Dearborn JT, Brown JA, Tokuda K, Izumi Y, Zorumski CF, Gutmann DH]
通讯作者:
Gutmann DH
DOI:
10.1016/j.neuroscience.2016.05.020
发表时间:
2016-08-04
期刊:
Neuroscience
影响因子:
3.3
作者:
[Stein LR, O'Dell KA, Funatsu M, Zorumski CF, Izumi Y]
通讯作者:
Izumi Y
DOI:
10.1016/j.neuropharm.2016.09.001
发表时间:
2016-12
期刊:
Neuropharmacology
影响因子:
4.7
作者:
[Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y]
通讯作者:
Izumi Y
共 15 条
NEUROSTEROIDS & PROXIMAL INHIBITION IN THE HIPPOCAMPUS
-
批准号:9589698
-
项目类别:
-
资助金额:$23.35万
-
财政年份:2018
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
ETHANOL, NEUROSTEROIDS & HIPPOCAMPAL PLASTICITY
-
批准号:8299168
-
项目类别:
-
资助金额:$36.76万
-
财政年份:2009
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
ETHANOL, NEUROSTEROIDS & HIPPOCAMPAL PLASTICITY
-
批准号:8099731
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2009
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
ETHANOL, NEUROSTEROIDS & HIPPOCAMPAL PLASTICITY
-
批准号:7934684
-
项目类别:
-
资助金额:$37.44万
-
财政年份:2009
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
ETHANOL, NEUROSTEROIDS & HIPPOCAMPAL PLASTICITY
-
批准号:7728059
-
项目类别:
-
资助金额:$36.72万
-
财政年份:2009
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
ETHANOL, NEUROSTEROIDS & HIPPOCAMPAL PLASTICITY
-
批准号:8497547
-
项目类别:
-
资助金额:$33.97万
-
财政年份:2009
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Modulation of Hippocampal Synaptic Plasticity
-
批准号:7608679
-
项目类别:
-
资助金额:$32.3万
-
财政年份:2007
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Modulation of Hippocampal Synaptic Plasticity
-
批准号:8052930
-
项目类别:
-
资助金额:$31.98万
-
财政年份:2007
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Modulation of Hippocampal Synaptic Plasticity
-
批准号:7798640
-
项目类别:
-
资助金额:$32.3万
-
财政年份:2007
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Modulation of Hippocampal Synaptic Plasticity
-
批准号:7252752
-
项目类别:
-
资助金额:$32.33万
-
财政年份:2007
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
PHYSIOLOGICAL STUDIES OF NEUROSTEROID ANALOGUES
-
批准号:7384099
-
项目类别:
-
资助金额:$32.76万
-
财政年份:2007
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
MODULATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY
-
批准号:8313018
-
项目类别:
-
资助金额:$43.5万
-
财政年份:2007
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Washington University Center for Translational Neuroscience
-
批准号:7321060
-
项目类别:
-
资助金额:$23.01万
-
财政年份:2006
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Effects of Ethanol on Hippocampal Synaptic Plasticity
-
批准号:6533653
-
项目类别:
-
资助金额:$22.14万
-
财政年份:2001
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Hippocampal Synaptic Plasticity and Aging
-
批准号:6631553
-
项目类别:
-
资助金额:$26.95万
-
财政年份:2001
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Effects of Ethanol on Hippocampal Synaptic Plasticity
-
批准号:6797413
-
项目类别:
-
资助金额:$22.14万
-
财政年份:2001
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Hippocampal Synaptic Plasticity and Aging
-
批准号:6509927
-
项目类别:
-
资助金额:$26.95万
-
财政年份:2001
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Hippocampal Synaptic Plasticity and Aging
-
批准号:6325466
-
项目类别:
-
资助金额:$26.95万
-
财政年份:2001
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Effects of Ethanol on Hippocampal Synaptic Plasticity
-
批准号:6652484
-
项目类别:
-
资助金额:$22.14万
-
财政年份:2001
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
Hippocampal Synaptic Plasticity and Aging
-
批准号:6922016
-
项目类别:
-
资助金额:$26.95万
-
财政年份:2001
-
负责人:CHARLES F ZORUMSKI
-
依托单位:
海外基金