Cancer Cell Biology

项目总结（见说明）： 癌症细胞生物学计划旨在通过催化DF/HCC科学家和临床医生之间的相互作用来实现癌症发病机制和治疗的新方法。其总体目标是促进“从实验室到临床”的合作，将基本发现带入临床，以及“从临床到实验室”的合作，当对特定疾病的临床特征的深入了解有助于推动对发病机制的基本发现时，最终导致新的治疗策略。 癌症细胞生物学计划的具体目标是：1）利用新兴技术来阐明肿瘤发生的细胞机制; 2）利用基础科学发现来激发新疗法的临床前和临床开发。 该计划的99名成员通过使用分子，生物化学和细胞生物学方法来描述和改变癌细胞行为而统一起来。他们代表所有DF/HCC机构。在2009年，成员收到了超过7930万美元的总赠款资金（TC），其中2210万美元来自NCI，4250万美元来自其他同行评审赞助商。成员在本项目期间（2006年至2010年）出版了1，546份出版物，其中5%是计划内出版物，26%是计划间出版物，20%是机构间出版物。项目间和项目内的合作不仅导致了新疗法的发展，而且还激发了基础科学研究的补充途径。 在2005年的CCSG更新中，该计划获得了优异的成绩。它准备在下一个项目期间继续这一轨迹。

PROJECT SUMMARY (See instructions): The Cancer Cell Biology Program seeks to enable new approaches to cancer pathogenesis and therapy by catalyzing interactions between DF/HCC scientists and clinicians. The overarching goal is to facilitate ""bench-to-bedside" collaborations, bringing basic discoveries into the clinic, and "bedside-to-bench" collaborations, when a deep knowledge of the clinical features of a particular disease helps drive fundamental discovery of pathogenesis mechanisms, ultimately leading to new treatment strategies. The specific aims of the Cancer Cell Biology Program are to: 1) exploit emerging technologies to elucidate the cellular mechanisms that underlie tumorigenesis; and 2) leverage basic science discoveries to inspire pre-clinical and clinical development of novel therapeutics. The 99 members of this Program are unified through their use of molecular, biochemical, and cell biological approaches to delineate and alter cancer cell behavior. They represent all DF/HCC institutions. In 2009, members received more than a total of $79.3 million in overall grant funding (TC), of which $22.1 million was from NCI and $42.5 million was from other peer-review sponsors. Members published 1,546 publications during the current project period (2006 to 2010), of which 5% were intra-programmatic, 26% were inter-programmatic, and 20% were inter-institutional. Inter- and intra-programmatic collaborations have not only led to the development of novel therapeutics, but have also inspired complementary avenues of basic scientific investigation. In the 2005 CCSG renewal, the program received an outstanding merit score. It is poised to continue that trajectory in the next project period.