Population mixture in evolutionary and medical genetics
进化和医学遗传学中的群体混合
基本信息
- 批准号:8461149
- 负责人:
- 金额:$ 27.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-05-01 至 2016-01-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAdmixtureAffectAfrican AmericanAreaBiologyCancer Center Support GrantChromosome MappingComputer softwareDataData SetDevelopmentDiseaseDisease AssociationEuropeanFrequenciesFundingGene FrequencyGenerationsGenesGeneticGenetic DriftGenetic MaterialsGenetic VariationGenomicsGeographyGrantHaplotypesHealthHereditary DiseaseHumanHuman GeneticsIndividualInheritedLaboratoriesLatinoLeadLinkage DisequilibriumMedical GeneticsMethodsModelingMutationOrganismPaperPhylogenetic AnalysisPopulationPopulation StudyPrincipal Component AnalysisProcessProstatePublic HealthPublicationsRecording of previous eventsResearchShapesSoftware ToolsSouth AsianStratificationTestingTreesUnited States National Institutes of HealthVariantWorkWritinganalytical methodbasedesigndisorder riskgene discoverygenetic linkagegenetic risk factorgenetic variantgenome-widehuman diseaseinsightmeetingsmethod developmentmigrationnext generation sequencingnovelpathogenprogramsstatisticstooluser friendly software
项目摘要
DESCRIPTION (provided by applicant): Mixture between populations is a fundamental process that shapes biology, genetic variation, and the risk for disease. Despite its importance, the analytical methods that are available to study mixture on a genome-wide scale are limited. This makes it a priority to develop methods that can analyze this history in the large data sets that are now practical to generate. No federal grant currently supports the development of such methods. This grant proposes to develop methods and make software available for studying mixture. The Aims are: (1) To develop tools that make inferences about mixture based on allele frequency and haplotype frequency differences. (2) To develop tools that estimate dates of mixture based on admixture linkage disequilibrium and genetic divergence data. We expect that this grant will be of value in three areas. (a) It will support the development of methods and user-friendly software that will be important for evolutionary and medical genetics. (b) It will support work that will result in insights relevant to finding disease genes in human populations that are recently or anciently admixed. (c) It will lead to new insights about human history as well as the history of other organisms. The connection to medical genetics is particularly important. Our laboratory's past work on the evolutionary history of populations has been intertwined with our work on disease gene mapping, and the approaches that we developed in both areas were synergistic. In particular, we have leveraged the history of admixture in human populations to make new gene discoveries and to understand variation in disease risk across populations. We expect to be able to make further connections between evolutionary and medical genetics by developing sophisticated approaches for understanding and modeling population mixture.
描述(由申请人提供):种群之间的混合是形成生物学、遗传变异和疾病风险的基本过程。尽管它很重要,但在全基因组范围内研究混合物的分析方法是有限的。这使得开发能够在现在可以实际生成的大型数据集中分析此历史的方法成为优先事项。目前没有联邦拨款支持开发这种方法。该基金建议开发方法并使软件可用于研究混合物。目标是:(1)开发基于等位基因频率和单倍型频率差异的混合推断工具。(2)开发基于外加剂连锁不平衡和遗传散度数据的混合年代估计工具。我们期望这笔赠款将在三个方面发挥价值。(a)它将支持开发对进化遗传学和医学遗传学很重要的方法和用户友好软件。(b)它将支持有助于在最近或古代混合的人群中发现疾病基因的工作。(c)它将使人们对人类历史和其他有机体的历史有新的认识。与医学遗传学的联系尤为重要。我们实验室过去对种群进化史的研究与我们对疾病基因定位的研究交织在一起,我们在这两个领域开发的方法是协同的。特别是,我们利用人类群体混合的历史来发现新的基因,并了解不同人群之间疾病风险的变化。我们希望能够通过开发复杂的方法来理解和模拟种群混合,从而在进化和医学遗传学之间建立进一步的联系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David E Reich其他文献
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{{ truncateString('David E Reich', 18)}}的其他基金
Advanced tools for using ancient DNA to study biology and history
使用古代 DNA 研究生物学和历史的先进工具
- 批准号:
10803645 - 财政年份:2021
- 资助金额:
$ 27.68万 - 项目类别:
Advanced tools for using ancient DNA to study biology and history
使用古代 DNA 研究生物学和历史的先进工具
- 批准号:
10467222 - 财政年份:2021
- 资助金额:
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Advanced tools for using ancient DNA to study biology and history
使用古代 DNA 研究生物学和历史的先进工具
- 批准号:
10427117 - 财政年份:2021
- 资助金额:
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Advanced tools for using ancient DNA to study biology and history
使用古代 DNA 研究生物学和历史的先进工具
- 批准号:
10051376 - 财政年份:2021
- 资助金额:
$ 27.68万 - 项目类别:
Advanced tools for using ancient DNA to study biology and history
使用古代 DNA 研究生物学和历史的先进工具
- 批准号:
10610875 - 财政年份:2021
- 资助金额:
$ 27.68万 - 项目类别:
Advanced tools for using ancient DNA to study biology and history
使用古代 DNA 研究生物学和历史的先进工具
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10586271 - 财政年份:2021
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$ 27.68万 - 项目类别:
Population mixture in evolutionary and medical genetics
进化和医学遗传学中的群体混合
- 批准号:
8608552 - 财政年份:2012
- 资助金额:
$ 27.68万 - 项目类别:
Population mixture in evolutionary and medical genetics
进化和医学遗传学中的群体混合
- 批准号:
8220483 - 财政年份:2012
- 资助金额:
$ 27.68万 - 项目类别:
Population structure in whole-genome disease scans
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