Quantum FX Micro-CT Scanner

描述（由申请人提供）：本申请申请PerkinElmer/Caliper量子FX微型ct扫描仪的资金，以支持在塔夫茨大学，塔夫茨医学中心（TMC）和塔夫茨Jean Mayer美国农业部人类营养研究中心在波士顿进行的研究。由9名资金充足的NIH调查人员组成的小组将是该仪器的主要用户，另外6名用户将占其使用量的75%左右。在癌症，心脏和代谢疾病和组织工程领域的前沿项目进行了描述。此时对该仪器的需求是至关重要的，因为目前在塔夫茨大学或塔夫茨医学中心都没有Micro-CT仪器可用于所描述的项目。该系统将被安置在Tufts/TMC小动物成像临床前测试设施中，在那里它将补充现有的光学和超声成像设备。选择该系统的依据是它证明适合拟议的项目，它能够以较低的辐射剂量产生高质量图像，其他机构用户证明其可靠性，以及它相对容易使用和与其他设施成像设备相结合。塔夫茨大学校长、医学和牙科学院院长、塔夫茨医学中心Jean Mayer人类营养中心和癌症中心主任以及该设施所在的分子生理学和药理学系主任大力支持将仪器添加到该设施。医学院院长已承诺为该仪器重新装修空间；有关机构将以服务合同支持的形式提供为期3年的特殊机构支持。该设施由国际原子能机构指导，仪器的日常管理和操作将由该设施的副主任和技术人员/经理负责，他们还将培训新用户。PI和几个主要用户在微型ct方面具有专业知识，该设施的副主任将在NIH小鼠成像设施接受微型ct基础知识和仪器使用方面的培训。两名具有CT专业知识的诊断成像放射科医生将担任顾问，为该仪器及其用户提供支持。由PI、塔夫茨大学、塔夫茨医学癌症中心、美国农业部人类营养研究中心、分子生理学和药理学部门以及实验动物医学部的代表组成的咨询委员会将监督量子FX微型ct扫描仪的使用，并制定使用和公平分享该仪器的政策。Caliper量子FX微型ct扫描仪的可用性将大大提高美国国立卫生研究院资助的塔夫茨大学和塔夫茨医学中心正在进行的研究的质量，并将刺激塔夫茨研究界各个组成部分之间的翻译研究和合作。

DESCRIPTION (provided by applicant): This application requests funds for a PerkinElmer/Caliper Quantum FX Micro-CT Scanner to support research being carried out at Tufts University, Tufts Medical Center (TMC) and the Tufts Jean Mayer USDA Human Nutrition Research Center in Boston. A group of 9 well-funded NIH investigators will be the major users of the instrument and along with 6 additional users will account for approximately 75% of its use. Cutting edge projects in the areas of cancer, cardiac and metabolic diseases and tissue engineering are described. Need for the instrument at this time is critical as there is currently n Micro-CT instrument available at either Tufts University or Tufts Medical Center for the projects that are described. The system will be housed in the Tufts/TMC Small Animal Imaging Preclinical Testing Facility where it will complement existing optical and ultrasound imaging equipment. Choice of the system was based on its demonstrated suitability for the proposed projects, its ability to produce high quality images at significantly lower radiation dose, evidenc of reliability from users at other institutions, and its relative ease of use and integration with other facility imaging equipment. Addition of the instrument to the Facility is strongly supported by the President of Tufts University, Deans of the Medical and Dental School, Directors of Jean Mayer Human Nutrition Center and the Cancer Center at Tufts Medical Center and the Chairman of the Department of Molecular Physiology and Pharmacology where the Facility is physically located. The Dean of the Medical School has pledged renovated space for the instrument; exceptional institutional support for instrument in the form of service contract support for 3 years will be provided by the institutions involved. The Facility is directed by the I and the instrument will be managed and operated on a day-to-day basis by the Associate Director and Technician/Manager of the Facility, who will also train new users. The PI and several major users have expertise in micro-CT and the Associate Director of the Facility will be trained at the NIH Mouse Imaging Facility in micro-CT fundamentals and instrument use. Two diagnostic imaging radiologists with CT expertise will serve as consultants to support the instrument and its users. An advisory committee consisting of the PI, representatives from Tufts University, Tufts Medical Cancer, the USDA Human Nutrition Research Center, the Department of Molecular Physiology and Pharmacology and the Division of Laboratory Animal Medicine will oversee use of the Quantum FX Micro-CT Scanner and develop policies for use and equitable sharing of the instrument. The availability of the Caliper Quantum FX Micro-CT Scanner will greatly enhance the quality NIH-funded research being carried out Tufts University and Tufts Medical Center and will stimulate translation research and collaboration among the various components of the Tufts research community.