Animal Resources Expansion for Biomedical Research

生物医学研究的动物资源扩展

• 批准号: 8525940
• 负责人: DONALD B CASEBOLT
• 金额: $ 49.3万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-22 至 2014-04-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8525940
• 关键词: Animal Housing; Animals; Beds; Biomedical Research; California; Censuses; Equipment; Faculty; Foundations; Funding; Future; Goals; Growth; Health; Health Sciences; House mice; Housing; Human; Institutes; Investments; Laboratories; Laboratory Animal Production and Facilities; Mus; Population; Refuse Disposal; Research; Research Infrastructure; Research Personnel; Research Support; Safety; System; Technology; Translational Research; Universities; Water; animal care; animal facility; animal resource; base; density; human disease; improved; landfill; meetings; mouse model; prevent; programs

DESCRIPTION (provided by applicant): The University of Southern California has demonstrated its commitment to scientific research aimed at understanding the foundations of human disease and to translational research aimed at improving human health. As we have expanded animal based research within our AAALAC-accredited animal care and use program to meet these goals, our research volume has grown to the point where the demand for housing animals, particularly mice, has reached the capacity of our existing animal facilities. We already have significant annual funding for biomedical research using mouse models and we are making every effort to maintain an upward trajectory of our biomedical research programs, many of which will use mice. On our two campuses, mouse cage numbers have increased dramatically in recent years. Furthermore, we expect this dramatic increase in mouse census to continue in the coming years. Therefore, continued investment in our animal research facility capacity to house mice will be necessary to prevent constraining future growth in research and future faculty recruitment for those investigators requiring mouse models. This project will leverage our significant investment in the construction of new biomedical research laboratory buildings and in improvements in existing animal research facilities. Despite these significant investments, we expect that we will need additional capacity to house mice in the coming years. For this reason, we are requesting mouse caging and equipment from your institute to house our rapidly expanding mouse census in high density individually ventilated racks. These racks and cages will be used immediately upon receipt in our existing facilities, which will not require any renovation to use this equipment. This equipment will greatly enhance the environmental quality for the animals housed, improve worker safety, and increase operational efficiency of these facilities. The use of this caging system represents a green and sustainable technology due to lowered water usage for cage washing and reduced used bedding disposal. This equipment will be absolutely necessary to support our future biomedical research programs.

描述（由申请人提供）：南加州大学表明了其对旨在了解人类疾病基础的科学研究和旨在改善人类健康的转化研究的承诺。为了实现这些目标，我们在 AAALAC 认证的动物护理和使用计划中扩大了基于动物的研究，我们的研究量已经增长到对圈养动物（特别是小鼠）的需求已经达到了我们现有动物设施的容量。我们已经为使用小鼠模型的生物医学研究提供了大量的年度资金，并且我们正在尽一切努力保持我们的生物医学研究项目的上升轨迹，其中许多项目将使用小鼠。近年来，在我们的两个校区，老鼠笼的数量急剧增加。此外，我们预计小鼠数量的急剧增加将在未来几年继续下去。因此，有必要继续投资我们的动物研究设施来容纳小鼠，以防止限制未来研究的增长以及未来需要小鼠模型的研究人员的教师招聘。该项目将利用我们在建设新的生物医学研究实验室大楼和改进现有动物研究设施方面的大量投资。尽管有这些重大投资，我们预计未来几年仍需要额外的空间来容纳老鼠。因此，我们请求贵机构提供小鼠笼和设备，以便在高密度独立通风的机架中容纳我们快速扩大的小鼠普查。这些架子和笼子将在收到后立即在我们现有的设施中使用，无需任何改造即可使用该设备。该设备将大大提高饲养动物的环境质量，提高工人的安全，并提高这些设施的运营效率。这种笼养系统的使用代表了一种绿色和可持续的技术，因为它减少了笼子清洗的用水量并减少了废垫料的处理。该设备对于支持我们未来的生物医学研究项目是绝对必要的。