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中文摘要
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描述(由申请人提供):兽医为有益于人类健康的科学发现做好了独特的准备,特别是当他们对比较生理学和病理学的广泛理解与机械或转化研究培训相结合时。然而,美国面临着具有生物医学研究专长的兽医日益短缺的问题。兽医暑期研究计划已经证明,在增加从事研究职业的兽医数量方面取得了成功,我们提议的明尼苏达大学T35研究培训计划“比较医学兽医暑期学者”将提供一种机制,有助于满足生物医学研究对更多兽医的需求。我们的T35研究培训计划的目标是为兽医专业的学生提供:1)在活跃的实验室和导师提供的发现环境中进行生物医学研究的机会; 2)以讲座和讨论的形式提供研究相关的经验,重点是实验设计,数据分析,研究交流,文献检索,赠款写作,以及负责任的行为和研究道德。该培训计划的长期目标是增加在完成兽医学位后进行生物医学研究培训的兽医数量,并最终增加成为生物医学科学中富有成效的独立调查员的兽医数量。我们的方法将包括为学生提供广泛的研究机会,从基本的细胞和分子实验室研究到理论和现场流行病学,再到转化和临床研究,所有这些都围绕着明尼苏达大学的一种医学,一种科学的中心主题。拟议的培训计划包括一组高素质的研究导师,提供广泛的最先进的研究经验,并为培训兽医研究提供丰富多样的环境。培训导师的研究实验室位于明尼苏达大学的圣保罗和明尼阿波利斯校区。计划教师分为两个主要的重点小组:1)炎症和慢性疾病和2)癌症生物学。在每个焦点小组有几个生物医学研究主题和教师之间的重大互动。T35计划教师研究人类疾病过程,自发性动物疾病模型和实验动物模型。导师包括一个补充临床训练的医生和兽医,有临床为基础的,校外资助的研究计划。总的来说,我们的培训环境将允许学员与各个领域的研究人员进行广泛的互动。在第一年,我们建议支持五名学生攻读DVM学位,每年增加一名学生,五年级共有九名学生。每个学生的培训时间为10周,从6月到8月。
英文摘要
DESCRIPTION (provided by applicant): Veterinarians are uniquely prepared for scientific discovery that benefits human health, particularly when their broad understanding of comparative physiology and pathology is coupled with mechanistic or translational research training. However, the United States suffers from an ever-worsening shortage of veterinarians with expertise in biomedical research. Summer research programs for veterinarians have had demonstrated success in increasing the number of veterinarians who pursue research careers, and our proposed T35 research training program "Veterinary Summer Scholars in Comparative Medicine" at the University of Minnesota will provide a mechanism that helps meet the need for greater numbers of veterinarians in biomedical research. The objectives of our T35 research training program are to provide veterinary students with: 1) opportunities to conduct biomedical research in an environment of discovery provided by active laboratories and mentors; and 2) research-relevant experiences in the form of lectures and discussions focused on experimental design, data analysis, research communication, literature searching, grant writing, and responsible conduct and ethics in research. The long-term goals of this training program are to increase the number of veterinarians who pursue biomedical research training after completing the veterinary degree and, ultimately, to increase the number of veterinarians who become productive independent investigators in the biomedical sciences. Our approach will consist of providing a wide breadth of research opportunities for students, from basic cellular and molecular bench research to theoretical and field epidemiology, to translational and clinical research, all built around the central theme of One Medicine, One Science at the University of Minnesota. The proposed training program includes a group of highly qualified research mentors, offers a wide array of state-of-the-art research experiences, and provides a rich and diverse environment for training veterinarians in research. The research laboratories of the training mentors are located on the St. Paul and Minneapolis campuses of the University of Minnesota. Program faculty is grouped in two major focus groups: 1) Inflammatory and Chronic Diseases and 2) Cancer Biology. Within each focus group there are several biomedical research themes and significant interactions among faculty. The T35 program faculty study disease processes in humans, spontaneous animal disease models, and experimental animal models. The mentors include a complement of clinically-trained physicians and veterinarians that have clinically-based, extramurally funded research programs. Overall, our training environment will allow the trainees extensive interactions with researchers in a variety of fields. In Year 1 we propose to support five students pursuing DVM degrees, increasing this number by one student per year for a total of nine students in Year 5. The duration of training for each student will be 10 weeks, from June to August.
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Expression of recombinant Fc receptors by engineered NK cells to enhance cancer cell killing
  • 批准号:
    10208351
  • 项目类别:
  • 资助金额:
    $43.99万
  • 财政年份:
    2016
  • 负责人:
    BRUCE K WALCHECK
  • 依托单位:
Expression of recombinant Fc receptors by engineered NK cells to enhance cancer cell killing
  • 批准号:
    10609803
  • 项目类别:
  • 资助金额:
    $43.18万
  • 财政年份:
    2016
  • 负责人:
    BRUCE K WALCHECK
  • 依托单位:
Expression of recombinant Fc receptors by engineered NK cells to enhance cancer cell killing
  • 批准号:
    10360537
  • 项目类别:
  • 资助金额:
    $43.18万
  • 财政年份:
    2016
  • 负责人:
    BRUCE K WALCHECK
  • 依托单位:
Immunosuppression by leukocyte ADAM17 during sepsis
  • 批准号:
    8700037
  • 项目类别:
  • 资助金额:
    $22.8万
  • 财政年份:
    2014
  • 负责人:
    BRUCE K WALCHECK
  • 依托单位:
海外基金