A Novel Adherence Technology for Ophthalmic Medications

摘要 支持慢性病患者用药管理的技术援助正在激增，在 电子远程医疗设备。药片组织者、提示者、监控器和用法传播者使 一系列家庭健康辅助工具，支持用户和照顾者进行避孕药管理和监测。超越散装 除了药丸，其他药物形式，如局部用药，在独特的药物输送系统中越来越受欢迎。 然而，局部用药用于促进和跟踪依从性的电子监测手段有限。 尽管不坚持的后果和口服药物一样令人担忧。例如，青光眼 是全世界导致失明的主要原因，然而患者对局部用药方案的依从性是 充其量也就是次优。由于几个独特的障碍，眼科药物的坚持令人望而生畏：1)复杂性-- 滴眼液的应用可能非常复杂，涉及每天服用几次的多种药物，2) 给药--视障患者通常不能正确识别药物和阅读标签，3) 不稳定--许多药物对极端条件有不良反应，以及4)缺乏患者选择--没有多种药物 容器存在功能丰富的提醒、监控、干预功能。此外，初选 使用眼药水的障碍是实际正确使用眼药水的问题。这 项目将利用我们世界级的用药依从性系统和我们团队的非凡技能集和 开发眼科药物分配系统的经验，该系统将指导、提醒、监控 以经济实惠、实用且用户敏感的模式进行沟通和报告。它包括一滴水 分配装置，确保只有一滴在无菌、安全和正确的情况下正确地滴在眼睛上 具有红外监控功能的应用。

ABSTRACT Technological aids supporting medication management for chronically ill patients are proliferating, offered in electronic telehealth devices. Pill organizers, reminders, monitors, and usage communicators have enabled an array of home health aids to support users and caregivers in pill management and monitoring. Beyond bulk pills, additional medication forms, such as topicals, are gaining popularity in unique drug delivery systems. However, topical medications have limited electronic monitoring means for promoting and tracking adherence even though the consequences of nonadherence are just as alarming as with oral meds. For example, glaucoma is a leading cause of blindness worldwide, yet patient compliance with topical medication regimens is suboptimal at best. Ophthalmic drug adherence is daunting due to several unique barriers: 1) complexity-- the application of eye drops can be highly complicated involving multiple drugs taken several times daily, 2) administration-- visually impaired patients often cannot correctly identify medication and read labels, 3) lability-- many drugs react adversely to extreme conditions, and 4) lack of patient options-- no multi-drug container exists with feature-rich reminding, monitoring, and intervention functions. Moreover, a primary barrier to administration of eye drops is the problematic issue of actually administering drops properly. This project will leverage our world-class medication adherence system and our team's exceptional skill sets and experience in developing an ophthalmic medication dispensing system that will instruct, remind, monitor, communicate, and report in a highly affordable, practical, and user-sensitive model. It includes a drop dispensing device that assures only one drop is properly applied to the eye in sterile, safe, and correct application with infrared monitoring.