Studies on the Prevalence, Risk Factors and Outcomes of Cancers in HIV in India

描述（由申请人提供）：在全球范围内，印度是艾滋病毒感染者人数最多的国家之一，估计有240万人。恶性肿瘤是已知的艾滋病毒感染的合并症，并且在世界许多地方的比例正在上升。在印度，艾滋病毒感染者中癌症的发病率和表现尚未得到很好的描述，未确诊的艾滋病毒感染患者可能以癌症作为其艾滋病毒感染的第一表现的比例尚不清楚。该提案的目标是获取印度北部一个主要癌症治疗和转诊中心1-2年期间癌症人群中艾滋病毒流行情况的信息。同样，我们将评估同一机构癌症筛查诊所（如乳腺癌、宫颈癌和前列腺癌）患者的艾滋病毒感染率。另一个目标是收集信息；人口统计数据、艾滋病病毒和临床状况、艾滋病病毒和癌症风险因素，以及艾滋病病毒和癌症患者的癌症发病率、癌症类型、分期、治疗和治疗结果等信息。此外，我们将类似地评估各种癌症风险因素和各种致癌病毒在癌症患者中的流行情况（与来自同一机构的同一HIV诊所的同时对照HIV+个体相比，这些个体在本研究的时间范围内没有发生癌症）。这将有助于评估艾滋病毒在各种癌症类型中的流行情况，并提供关于艾滋病毒感染者中短期癌症发病率、各种风险因素和癌症发展的辅助因素的信息。本研究确定的癌症和艾滋病毒个体将登记在癌症和艾滋病毒登记处

DESCRIPTION (provided by applicant): Globally, India has one of the largest populations of HIV-infected people, estimated at 2.40 million individuals. Malignancy is a known co-morbidity of HIV infection and is growing in proportion in many parts of the world. The incidence and manifestations of cancer in HIV-infected individuals in India has not yet been well characterized, and the proportion of patients with undiagnosed HIV infection who may be presenting with cancer as their first manifestation of HIV infection is not known. The goal of this proposal is to obtain information on the prevalence of HIV in the cancer population seen over a 1-2 year period at a major cancer treatment and referral center in Northern India. We will similarly assess the HIV prevalence of patients presenting to cancer screening clinics at the same institution (e.g. breast, cervical and prostate). Another goal is to collect information; demographics, HIV and clinical status at presentation, HIV and cancer risk factors, as well as information on incidence of cancer, cancer types, stage, treatments and treatment outcomes in patients with HIV and cancer. In addition we will similarly assess various cancer risk factors and the prevalence of various oncogenic viruses in patients with incident cancers (compared to concurrent control HIV+ individuals from the same HIV clinic at the same institution that do not develop cancer in the timeframe of this study. This will allow assessment of HIV prevalence in various cancers types as well as provide information on the short- term cancer incident and various risk factors and co-factors for cancer development among HIV-infected persons. Identified cancer and HIV individuals from this study will be enrolled in a cancer and HIV registry and specimen/tissue bank, which we will help establish, for prospective follow-up and specimen collection to obtain data on cancer and HIV treatments and clinical outcomes and to provide a cohort for future research studies, including epidemiologic, laboratory and possible clinical trial. Establishment of the HIV and cancer registry with collected tumor and blood specimens will provide our Indian investigator colleagues with a valuable resource for further research (with additional future Indian outside funding). This study will involve a collaboration between investigators at UCLA, the All India Institute for Medical Sciences (AIIMS) in New Delhi and the Dr. B.R. Ambedkar Institute and Rotary Cancer Hospital (DR BRAIRCH) at AIIMS The overall goal is to better characterize the important association of HIV and cancer in India and to identify risk factors and potential viral co-factors which may ultimately service as the basis for future therapeutic and prevention interventions for this important co-morbidity in HIV.