South American Prevention of HIV Research Training Program (SAPHIR)

描述(由申请人提供)：有效的艾滋病毒预防干预措施需要对特定文化背景下的行为、生物和社会传播模式进行综合分析。南美艾滋病毒预防研究计划(SAPHIR)计划建立在加州大学洛杉矶分校全球卫生计划现有培训计划的基础上，为来自美国的发展中的研究人员提供在国际环境中全面预防艾滋病毒的密集、结构化的教育和实践研究培训计划。具体目标1.根据拉丁美洲艾滋病毒预防领域的一个重点研究主题，为来自美国的发展中研究人员提供有组织的教育和培训计划。萨菲尔项目实习生与来自美国和拉丁美洲的研究导师结成伙伴，开发一个独立的研究项目，包括对现有数据的二次分析和原始研究研究方案的设计。潜在的研究主题包括与拉丁美洲特定背景下的艾滋病毒预防有关的行为、流行病学、临床和实验室问题。具体目标2.提供教学方案和互动研讨会，解决国际环境中艾滋病毒预防的综合办法。培训计划包括每周一系列关于全球艾滋病毒预防关键领域的讲座和研讨会，包括讲座、期刊俱乐部、研究报告和伦理案例会议。该教育计划的概念框架是基于全面预防艾滋病毒的科学学科的交叉。具体目标3.建设具有个别科学专长领域的国际调查人员和研究中心的合作网络的能力，以便为拉丁美洲的艾滋病毒预防研究制定综合办法。除了对年轻研究人员的实践培训外，该计划的次要目标是促进参与研究中心的机构间合作和能力建设。该计划的毕业生将完成以下目标：1)获得全面艾滋病毒预防(流行病学、诊断、治疗和预防)四个核心领域的知识基础；2)完成二次数据分析，并准备相应的摘要提交给国际科学会议；3)设计独立的研究子研究；4)编写符合加州大学洛杉矶分校人类研究对象保护委员会定义的对人类受试者进行研究的伦理要求的研究方案；5)提交供同行审查的资金提案，并收到书面总结声明；以及6)在当地社区场所和项目学员和导师的年度会议上展示他们的研究成果。所有萨菲尔的毕业生都将获得必要的接触、技能和实践经验，以获得进入竞争性博士后培训计划的许可，并在国际艾滋病毒预防研究领域建立学术生涯。 与公共卫生相关：最新一代的内科学者认识到全球预防艾滋病毒的方法的必要性，但缺乏在国际地点进行研究培训的有组织的机会。一个专门的国际艾滋病毒预防研究的教育和实践培训计划将填补艾滋病研究方面的一个重要缺陷。

DESCRIPTION (provided by applicant): Effective HIV prevention interventions require the integrated analysis of behavioral, biological, and social transmission patterns in specific cultural contexts. The South American Program in HIV Prevention Research (SAPHIR) program builds on existing training programs at the UCLA Program in Global Health to offer developing investigators from the U.S. an intensive, structured program of education and practical research training on comprehensive HIV prevention in an international environment. Specific Aim 1. To provide developing researchers from the U.S. with a structured program of education and training based on a focused research topic within the field of HIV prevention in Latin America. SAPHIR program trainees are paired with research mentors from the U.S. and Latin America to develop an independent research program incorporating both secondary analysis of existing data and design of an original research study protocol. Potential research topics include behavioral, epidemiological, clinical and laboratory issues related to HIV prevention within specific Latin American contexts. Specific Aim 2. To provide a program of didactic instruction and interactive seminars addressing integrated approaches to HIV prevention in international settings. The training program includes a weekly series of lectures and seminars on key areas of global HIV prevention, including lectures, journal clubs, research presentations, and ethics case conferences. The conceptual framework for the educational program is based on the intersection of scientific disciplines in comprehensive HIV prevention. Specific Aim 3. To build the capacity of a collaborative network of international investigators and research centers with individual areas of scientific expertise to produce integrated approaches to HIV prevention research in Latin America. In addition to practical training for young investigators, a secondary aim of the program is to promote inter-institutional collaboration and capacity-building for participating research centers. Graduates of the program will accomplish the following goals: 1) Acquire a foundation of knowledge in the four core areas of comprehensive HIV prevention (epidemiology, diagnosis, treatment, and prevention); 2) Complete a secondary data analysis and prepare a corresponding abstract for submission to an international scientific conference; 3) Design an independent research sub-study; 4) Prepare a study protocol that meets requirements for the ethical conduct of research with human subjects as defined by the UCLA Committee for the Protection of Human Research Subjects; 5) Submit a funding proposal for peer review and receive a written summary statement; and 6) Present results of their research in a local community venue and at an annual conference of program trainees and mentors. All SAPHIR graduates will acquire the exposure, skills, and practical experience necessary to gain admission to competitive post-doctoral training programs and to build an academic career in international HIV prevention research. PUBLIC HEALTH RELEVANCE: The newest generation of physician scholars recognizes the need for global approaches to HIV prevention but lacks structured opportunities for research training in international sites. A dedicated program of education and practical training in international HIV prevention studies will fill an important deficit in AIDS research.