Precision Ventilation -Anesthesia Delivery System for Larger-Animal PET/CT Imagin

精密通气 - 大型动物 PET/CT 成像麻醉输送系统

• 批准号: 8448411
• 负责人: Jonathan Paul James Carney
• 金额: $ 14.88万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448411
• 关键词: Advanced Development; Anesthesia procedures; Animal Experimentation; Animals; Breathing; Chronic Obstructive Airway Disease; Clinical; Coupling; Data; Development; Disadvantaged; Economic Inflation; Environment; Environmental air flow; Equipment; Forms Controls; Funding; Gases; Goals; Image; Inflammatory; Information Management; Lung; Lung diseases; Modeling; Monitor; Morphologic artifacts; Motion; PET/CT scan; Patients; Phase; Physiological; Positron-Emission Tomography; Protocols documentation; Request for Proposals; Research Personnel; Resolution; Scanning; Science; Site; Solutions; Spirometry; Structure; System; Time; Transplantation; Tuberculosis; Universities; Vendor; base; chemotherapy; data acquisition; human subject; in vivo; interest; neuroimaging; nonhuman primate; novel; pre-clinical; pulmonary arterial hypertension; pulmonary function; respiratory; response; vaporization

DESCRIPTION (provided by applicant): This proposal requests funds for an Aisys ventilation-anesthesia delivery and monitoring system to be used with a novel PET/CT imaging platform geared specifically towards the imaging of larger research animals such as non-human primates. This preclinical imaging system, based on the micro PET scanner and a clinical neuro CT scanner (CereTom), was initially developed by the investigators and the respective vendors to investigate response to chemotherapy in a non-human primate model of tuberculosis, and a system dedicated to this purpose is located in an animal biosafety level 3 (ABSL3) environment. The investigators have also upgraded a micro PET scanner sited in the University of Pittsburgh P.E.T. Facility to be a preclinical PET/CT available for other applications, for which the requested equipment is intended. As opposed to clinical PET/CT imaging of human subjects, where patient respiratory motion is a frequent problem, the use of controlled ventilation-anesthesia in preclinical imaging can minimize degrading effects in the PET images through the use of novel protocols. The result is intrinsically co-registered PET/CT images that are essentially free of respiratory motion artifacts. Achieving this requires a more sophisticated ventilation-anesthesia solution than that required for neuroimaging applications, where the goal is simply to maintain stable physiologic function. The Aisys system combines enhanced ventilation features, electronically controlled gas delivery and agent vaporization with anesthesia and vital signs monitoring and information management in a single integrated system. A disadvantage of PET data acquisition with standard ventilation protocols or free breathing is that only a fraction of the acquired data corresponds to any given phase of the respiratory cycle. This system will give us the ability to precisely control the form of the breathing duty cycle such that most of the time is spent at a known static state of inflation, which results in the majority f the acquired PET data corresponding to that state. The data not corresponding to this state may be rejected through respiratory gating or the images may be acceptable even without gating applied. Breath-hold CT images are acquired at the same level of inflation. The use of precision ventilation control is especially important for the micro PET/CereTom system given its high PET spatial resolution, as compared to clinical PET/CT systems, which may be obviated if a detailed structure of interest is blurred due to respiratory motion. The lung spirometry feature on the Aisys system can be used to evaluate global pulmonary function at the time of scanning to compliment the in vivo images obtained. The coupling of the requested system to the preclinical PET/CT system will further advance developments underway in: infectious and inflammatory lung diseases such as COPD, pulmonary arterial hypertension, novel influenzas, PET probe development, and transplantation science.

描述（由申请人提供）：该提案要求为 Aisys 通气麻醉输送和监测系统提供资金，该系统与专门针对大型研究动物（例如非人类灵长类动物）成像的新型 PET/CT 成像平台一起使用。这种基于微型 PET 扫描仪和临床神经 CT 扫描仪 (CereTom) 的临床前成像系统最初由研究人员和各自的供应商开发，用于研究非人类灵长类结核病模型对化疗的反应，专用于此目的的系统位于动物生物安全 3 级 (ABSL3) 环境中。研究人员还升级了位于匹兹堡大学 P.E.T. 的微型 PET 扫描仪。设施是可用于所需设备的其他应用的临床前 PET/CT。与人类受试者的临床 PET/CT 成像相反，患者呼吸运动是一个常见问题，在临床前成像中使用受控通气麻醉可以通过使用新颖的方案最大限度地减少 PET 图像的退化影响。结果是本质上共同配准的 PET/CT 图像基本上没有呼吸运动伪影。实现这一目标需要比神经影像应用所需的更复杂的通气麻醉解决方案，神经影像应用的目标只是维持稳定的生理功能。 Aisys 系统将增强的通气功能、电子控制的气体输送和麻醉剂汽化结合在一起 以及生命体征监测和信息管理在一个单一的集成系统中。使用标准通气方案或自由呼吸采集 PET 数据的缺点是，所采集数据中只有一小部分对应于呼吸周期的任何给定阶段。该系统将使我们能够精确控制呼吸工作循环的形式，例如 大部分时间都花在已知的静态膨胀状态，这导致所采集的 PET 数据大部分与该状态相对应。不对应于该状态的数据可以通过呼吸门控被拒绝，或者即使不应用门控图像也可以是可接受的。屏气 CT 图像是在相同的充气水平下获取的。与临床 PET/CT 系统相比，由于微型 PET/CereTom 系统具有高 PET 空间分辨率，因此使用精确通气控制对于微型 PET/CereTom 系统尤其重要，如果感兴趣的详细结构由于呼吸运动而模糊，则可能会避免这种情况。 Aisys 系统上的肺活量测定功能可用于评估扫描时的整体肺功能，以补充获得的体内图像。所需系统与临床前 PET/CT 系统的结合将进一步推动以下领域的发展：传染性和炎症性肺部疾病，如慢性阻塞性肺病、肺动脉高压、新型流感、PET 探针开发和移植科学。