Lung Cancer Disparities Center: Jointly Addressing Race & Socioeconomic Status

描述(由申请人提供)：肺癌差异中心将是一个跨学科的研究中心(包括基于社区的参与性研究)、核心支持和传播活动，重点是了解和改变肺癌连续统一体上种族/民族和社会经济地位(SES)差异的决定因素。吸烟是肺癌的主要原因，也是个人和人群高风险的关键标志；如果不吸烟，肺癌将是罕见的。因此，确定有效的策略以防止吸烟和促进吸烟者戒烟对于降低肺癌风险至关重要。我们还需要更好地了解社会环境对肺癌的发病、病程和预后的影响。这五个项目和核心有以下具体目标：1)开发和测试新的烟草控制干预措施，解决引发和维持吸烟行为的社会背景；2)开发和应用关于以社区为中心的研究的复杂概念、措施和方法，用于中心的所有活动；3)利用多学科研究团队的专业知识，从社会决定因素的角度看待导致肺癌存活率社会差异的临床因素和其他个人水平因素，以及可能影响肺癌发病、病程和结果的遗传因素；4)改进现有的概念和方法，以了解和描述种族/民族和SES对肺癌的共同贡献；5)制定强有力的尖端培训计划，以培训未来的人口健康研究人员；以及6)资助高度创新和高风险的试点项目，为共同了解种族/民族和SES对肺癌差异及其决定因素的研究和应用提供信息。值得注意的是，这项工作将由一个对人口健康和健康差距做出重大贡献的跨学科研究人员团队完成，在这样一个跨学科中心得到大量智力和资金支持的机构环境中。 相关性：肺癌差异中心将确定与种族/民族和风险模式相关的环境条件如何通过影响导致健康不良的多个途径来导致肺癌预后的社会差异。我们的中心专注于一种特定的疾病(肺癌)及其关键的行为决定因素(吸烟)。吸烟是肺癌的主要原因，也是个人和人群高风险的关键标志；如果不吸烟，肺癌将是罕见的。

DESCRIPTION (provided by applicant): The Lung Cancer Disparities Center will be an interdisciplinary center for research (including community based participatory research), core support and dissemination activities focused on understanding and altering the determinants of racial/ethnic and socioeconomic status (SES) disparities along the continuum of lung cancer. Cigarette smoking is the primary cause of lung cancer and the key marker of high-risk in both individuals and populations; without cigarette smoking, lung cancer would be rare. Thus, identifying effective strategies to prevent the initiation of smoking and facilitate cessation among smokers is critical to reducing the risk of lung cancer. We also need to better understand the contribution of the social environment to the onset, course, and outcomes of lung cancer. The five projects and cores have the following specific aims: 1) develop and test novel tobacco control interventions that address the social context that initiate and sustain smoking behavior; 2) develop and apply sophisticated concepts, measures, and methods regarding community-focused research to all of the activities of Center; 3) draw on the expertise of a multidisciplinary team of researchers to bring a social determinants perspective to the clinical factors and other individual level factors that lead to social disparities in lung cancer survival and the genetic factors that could affect the onset, course and outcomes of lung cancer; 4) refine existing conceptual and methodological approaches to understanding and describing the joint contribution of race/ethnicity and SES to lung cancer; 5) develop a strong and cutting-edge training program to train the population health investigators of the future; and 6) fund highly innovative and high-risk pilot projects to inform research and application concerned with jointly understanding race/ethnicity and SES to disparities in lung cancer and its determinants. Significantly, this work will be accomplished by a transdisciplinary team of researchers who have made seminal contributions to population health and health disparities, in an institutional environment in which there is substantial intellectual and financial support for such an interdisciplinary Center. RELEVANCE: The Center on Lung Cancer Disparities will identify how environmental conditions - related to race/ethnicity and patterns of risk produce social disparities in lung cancer outcomes by influencing multiple pathways leading to poor health. Our Center focuses on one specific condition (lung cancer) and its key behavioral determinant (cigarette smoking). Cigarette smoking is the primary cause of lung cancer and the key marker of high-risk in both individuals and populations; without cigarette smoking, lung cancer would be rare.