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WaNPRC Macaca nemestrina SPF Breeding Colony

WaNPRC 猕猴 SPF 育种群

基本信息

批准号：
8507290
负责人：
DONALD RICK LEE
金额：
$ 201.08万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8507290
关键词：
Acquired Immunodeficiency Syndrome Address Adult Animals Area Biomedical Research Breeding Cercopithecine Herpesvirus 1 Communication Communities Development Diagnostic Disease Ensure Evaluation Female Foundations Funding Future Grant Health Housing Human Human Resources IACUC Immunology Institution Investigation Laboratories Local Microbicides Macaca Macaca mulatta Macaca nemestrina Maintenance Modeling Monitor Monkeys Morbidity - disease rate Mycobacterium tuberculosis Pathogenesis Personnel Management Pharmaceutical Preparations Practice Management Predisposition Primates Process Program Evaluation Protocols documentation Recording of previous events Research Research Personnel Research Project Grants Resources SIV Safety Simian Retroviruses Site Solid Specific Pathogen Frees Structure Subfamily lentivirinae System Texas Therapeutic Agents Tuberculosis United States National Institutes of Health Vagina Viral Virus Washington animal breeding animal care animal facility animal resource demographics experience geographically distant germ free condition knowledge base laboratory facility meetings metropolitan mortality nonhuman primate operation programs public health relevance simian virus transmission process vaccine development virology

项目摘要

DESCRIPTION (provided by applicant): Macaca nemestrina are an invaluable resource for AIDS-related studies in vaccine development, therapeutic agent discovery, topical microbicide evaluation, and basic lentiviral virology, pathogenesis and immunology. The Washington National Primate Research Center (WaNPRC) seeks support to extend maintenance and continue expansion of the existing M. nemestrina specific pathogen-free breeding (SPF) colony. This colony is free of several viral agents (SIV, SRV, STLV, CHV) and tuberculosis. We seek support to expand the colony to more fully meet NIH research needs at WaNPRC and elsewhere. This proposal extends successful management and housing practices developed over the course of the previous grant which provide a solid, proven foundation for continued expansion of the colony. The existing SPF animals will be relocated as needed to consolidate the SPF M. nemestrina breeding colony at the Shin Nippon Biomedical Laboratory facility at Alice, Texas. Virologic surveillance will continue to be provided by the WaNPRC Diagnostic Laboratory and management will continue as an integrated process between WaNPRC and SNBL personnel. This foundation will be expanded to ensure continued successful expansion of this important SPF macaque colony.

描述（由申请人提供）：Macaca nemestrina是疫苗开发、治疗剂发现、局部杀微生物剂评价和基础慢病毒学、发病机制和免疫学中艾滋病相关研究的宝贵资源。华盛顿国家灵长类动物研究中心（WaNPRC）寻求支持，以延长维护和继续扩大现有的M。Nemestrina特异性无病原体繁殖（SPF）菌落。该菌落不含几种病毒因子（SIV、SRV、STLV、CHV）和结核病。我们寻求支持，以扩大殖民地，以更充分地满足国家卫生研究院的研究需要在WaNPRC和其他地方。这项建议延续了上一次批地期间发展起来的成功管理和住房做法，为继续扩大殖民地提供了坚实的、行之有效的基础。现有SPF动物将根据需要重新安置，以巩固SPF M。nemestrina繁殖殖民地在新日本生物医学实验室设施在爱丽丝，得克萨斯州。病毒学监测将继续由WaNPRC诊断实验室提供，管理将继续作为WaNPRC和SNBL人员之间的综合过程。该基金会将扩大，以确保继续成功扩大这一重要的SPF猕猴群体。