Biostatistics Core

生物统计核心(核心B)将在设计、实施和分析 根据该提案产生的临床试验、动物研究和相关研究项目。世界银行的目标是 核心是在研究的所有阶段向六个项目提供生物统计支助。核心员工将 在开始研究之前咨询研究人员，以审查研究目标并协助选择 有效的设计和样本大小，将提供足够的力量来实现目标。用于临床 研究，一名核心成员将与调查人员一起进行方案审查，并协助制定方案， 样本量的确定，中期分析的计划，以及如果适用，随机化。核心员工将 使用适当的统计数据为POI调查人员执行统计分析和数据探索 方法；编写结果报告；协助准备演示文稿和撰写 手稿的统计组成部分；并就后续研究的设计进行咨询。核心导演 在应用和方法论统计研究方面有广泛的经验，这将允许 在下列情况下，应采用适当的方法以及修改或开发新方法 需要的。

The Biostatistics Core (Core B) will provide biostatistical expertise in the design, conduct and analysis of the clinical trials, animal studies and related research projects generated under this proposal. The goals of the Core are to provide biostatistical support to the six projects at all phases of the research. Core staff will consult with investigators prior to the initiation of studies to review study objectives and assist in selecting efficient designs and sample sizes that will provide adequate power to address the objectives. For clinical studies, a Core member will conduct a protocol review with investigators and assist in protocol development, sample size determination, plans for interim analyses, and if applicable, randomization. Core staff will perform statistical analyses and data exploration for POI investigators using appropriate statistical methodologies; prepare reports of results; assist with the preparation of presentations and writing of statistical components of manuscripts; and consult on the design of subsequent research. The Core director has widespread experience in applied and methodologic statistical research, which will allow for the most appropriate methodologies to be utilized as well as for modification or development of new methods if needed.