UAB Multidisciplinary Clinical Research Center

UAB多学科临床研究中心

• 批准号: 8471825
• 负责人: S Louis Bridges
• 金额: $ 84.09万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-16 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8471825
• 关键词: Adolescent; Adult; Advisory Committees; African American; Arthritis; Autoimmunity; Bacteria; Bioinformatics; Biological Markers; Biometry; Cartilage; Cells; Child; Clinical Research; Clinical Trials; Collaborations; Connective Tissue; Data; Development; Diagnosis; Educational process of instructing; Electronics; Ensure; Epidemiology; Evaluation; Faculty; Gene Expression; Gene Expression Regulation; Genetic; Genetic Determinism; Health Services Research; Health Technology; Immune; Immune response; Immunology; Inflammation; Intestines; Medicine; Methodology; Monitor; Musculoskeletal; Musculoskeletal Diseases; Outcome; Patient Care; Patients; Population; Positioning Attribute; Prevention; Program Development; Research; Research Methodology; Research Personnel; Resources; Rheumatism; Role; Safety; Spondylarthritis; Techniques; Therapeutic; bone; cell type; cohort; data management; functional genomics; gut microbiota; improved; innovation; multidisciplinary; neurobehavioral; novel; programs; public health relevance; rheumatologist; tool

DESCRIPTION (provided by applicant): The UAB MCRC is a multidisciplinary program uniquely positioned to promote research related to the causes, diagnoses, treatments and improved care of patients with arthritis and musculoskeletal diseases. The MCRC builds on the capabilities of the UAB Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center (CAMAC) and its thematic workgroups (Experimental Therapeutics & Biomarkers; Neurobehavioral Medicine; Epidemiology, Prevention, & Outcomes; Genetics and Functional Genomics; Immunology, Autoimmunity & Inflammation; Bone, Cartilage and Connective Tissue). An outstanding MCRC Methodology Core is comprised of experts in biostatistics (Redden, Howard, McGwin, Aslibekyan), data management (Westfall), statistical genetics and bioinformatics (Cui, Lefkowitz, Liu) and health services research (Kilgore). All have a proven record of collaborative clinical investigation in musculoskeletal diseases. This proposal includes 3 innovative projects: 1. Genetic Determinants of Cell Type-Specific Gene Expression in RA (Brown/Bridges); 2. Facilitating Treat-to-Target Strategies Using Novel Health Technology with Decision Support (Curtis); 3. Adaptive Immune Responses to Gut Microbiota in Juvenile & Adult Spondyloarthritis (Elson). Projects 1 and 3 focus on populations for which there is a paucity of clinical research: (African-Americans with RA and juvenile spondyloarthritis). All projects leverage and expand upon substantial existing resources, including ongoing cohorts. The Administrative Core coordinates MCRC activities, sets the strategic agenda, facilitates interactions and collaborations, promotes scientific development, and performs evaluation of MCRC programs. Four advisory groups have been established to assist the MCRC Director and Associate Director in maximizing the strengths of the MCRC's projects, as well as in identifying and correcting weaknesses: 1. Executive Committee; 2. Internal Advisory Committee; 3. External Advisory Committee; 4. Data Safety Monitoring Committee. The Scientific Development Program, which promotes the introduction and development of new techniques and nurtures young and new faculty in arthritis and musculoskeletal disease research, ensures the continued energy and vitality of this MCRC.

描述（由申请人提供）：UAB MCRC是一项多学科计划，旨在促进与原因，诊断，治疗和改善关节炎和肌肉骨骼疾病患者的护理有关的研究。 MCRC建立在UAB全面关节炎，肌肉骨骼和自身免疫中心（CAMAC）及其主题工作组（实验性治疗和生物标志物；神经性疾病医学；流行病学，流行病学，预防和功能性基因和自身的骨骼，自身，自动化骨骼和自动化学;结缔组织）。出色的MCRC方法论核心由生物统计学专家（Redden，Howard，McGwin，Aslibekyan），数据管理（Westfall），统计遗传学和生物信息学（CUI，Lefkowitz，Liu）和健康服务研究（KILGORE）组成。所有人在肌肉骨骼疾病中都有合作临床研究的可靠记录。该建议包括3个创新项目：1。RA中细胞类型特异性基因表达的遗传决定因素（棕色/桥梁）； 2。使用新颖的卫生技术和决策支持（Curtis）促进对待靶向策略； 3。少年和成人脊椎关节炎（Elson）中对肠道微生物群的适应性免疫反应。项目1和3的重点是临床研究很少的人群：（非裔美国人患有RA和少年脊椎关节炎）。所有项目都利用并扩展了现有的大量资源，包括持续的人群。行政核心协调MCRC活动，设定战略议程，促进互动和协作，促进科学发展，并对MCRC计划进行评估。已经成立了四个咨询小组，以协助MCRC主任兼副董事最大化MCRC项目的优势，以及确定和纠正弱点：1。执行委员会； 2。内部咨询委员会； 3。外部咨询委员会； 4。数据安全监测委员会。科学发展计划促进了新技术的引入和开发，并培养了关节炎和肌肉骨骼疾病研究的年轻和新教师，可确保该MCRC的持续能量和活力。