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A Study of ILV-94 (Anti-22 Antibody) Administered via IV in Atopic Dermatitis

A Study of ILV-94 (Anti-22 Antibody) Administered via IV in Atopic Dermatitis
ILV-94(抗 22 抗体)静脉注射治疗特应性皮炎的研究
批准号:
8580222
负责人:
Emma Guttman
金额:
$63.15万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-09-01 至 2018-08-31

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中文摘要
翻译
描述(由申请人提供):特应性皮炎(AD)是最常见的炎症性皮肤病,影响高达3-4%的成人和25%的儿童,其中大多数是中度至重度AD类别的一部分,并且极难控制。目前,AD与Th2和最近描述的Th22 t细胞亚群的激活有关,而与牛皮癣不同的是,它具有最小的Th17成分。在银屑病中,IL-17A细胞因子或其受体的抗体中和IL-17/Th17可导致大多数治疗对象的疾病逆转,很少有与免疫拮抗相关的不良反应。我们假设新发现的Th22通过产生IL-22在AD中起关键的致病作用。IL-22促进表皮增生,抑制表皮分化,这是AD的主要特征。因此,我们假设IL-22在AD中是一个“驱动”细胞因子,类似于IL-17在牛皮癣中的作用。ILV-094是一种与IL-22高特异性结合的人IgGIA抗体,是一种有效的IL中和剂
英文摘要
DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is the most common inflammatory skin disorder, affecting up to 3-4% of adults and 25% of the children, most of which are part of the moderate-to-severe AD category, and which is extremely difficult to control. Currently there is a large unmet need for effective systemic treatment AD is associated with activation of Th2 and the recently described Th22 T-cell subsets, while unlike psoriasis, it has minimal Th17 component. In psoriasis neutralization of IL-17/Th17 by antibodies to IL-17A cytokine or to its receptor can lead to disease reversal in majority of treated subjects, with few adverse effects related to immune antagonism. We hypothesize that the newly discovered Th22, has a key pathogenic role in AD through the production of IL-22. IL-22 promotes epidermal hyperplasia and inhibits epidermal differentiation, which are major features of AD. Thus, we postulate that IL-22 is a "driver" cytokine in AD, analogous to IL-17 in psoriasis. ILV-094, a human IgGIA antibody that binds with high specificity to IL-22 is a potent neutralizer of IL 22 activity. Multiple studies showed that ILV-094 has favorable pharmacokinetics and toxicity profiles. This study is the first to explore the clinical and biological effects of blocking IL-22 n AD. Our specific aims are: 1 .To assess the safety, tolerability and clinical efficacy of intravenous (IV) administration of an IL-22 neutralizing antibody ILV-094 to subjects with moderate-to-severe AD; 2.To test the hypothesis that the abnormal epidermal hyperplasia and differentiation abnormalities in AD are attributable to IL-22 cytokine; and 3.To determine the impact of IL-22 blockade on suppression of Th2 and T22 activation. This is a placebo-controlled, double-blind, study of IV administration of ILV-094 / placebo to AD patients, assigned in a 2:1 ratio (active vs. placebo). A total of 6 IV doses will be administered over 10 weeks. Patients will be followed for 10 additional weeks. The clinical effects on AD disease activity will be evaluated by change in the Scoring of AD (SCORAD) and investigator's global assessment (IGA) indices at week 12. Biopsies and blood samples collected at baseline, and weeks 4 and 12, will be analyzed by immunohistochemistry, RTPCR and gene arrays.
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Role of Skin Barrier and Immune Alterations in Allergic Sensitization
  • 批准号:
    10633370
  • 项目类别:
  • 资助金额:
    $28.39万
  • 财政年份:
    2023
  • 负责人:
    Emma Guttman
  • 依托单位:
Characterizing the Immune Response to COVID-19 Infection in Atopic Dermatitis
Developing a Molecular Map of Atopic Dermatitis Across Ethnicity and Severity Subtypes.
Developing a Molecular Map of Atopic Dermatitis Across Ethnicity and Severity Subtypes.
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