Patterned Microtexture for Improved Durability of Orthopedic Knee Implants

图案化微观纹理可提高骨科膝关节植入物的耐用性

• 批准号: 8653062
• 负责人: Ronald L Jacobsen
• 金额: $ 9.66万
• 依托单位: MOUND LASER AND PHOTONICS CENTER, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-19 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8653062
• 关键词: Ablation; Achievement; Affect; Alloys; American; Body Weight; Cell Nucleus; Data; Development; Devices; Electrons; Electrostatics; Enhancement Technology; Excision; Failure; Film; Friction; Gait; Generations; Health Care Costs; Healthcare Systems; Heating; Implant; Industry; Knee; Knee joint; Knowledge; Laboratories; Lasers; Lead; Life; Liquid substance; Lubricants; Lubrication; Manufacturer Name; Mechanics; Medical Device; Metallurgy; Methods; Modeling; Motion; Operative Surgical Procedures; Orthopedics; Pain; Patients; Pattern; Performance; Phase; Physiologic pulse; Polishes; Process; Property; Qualifying; Research; Risk; Savings; Services; Simulate; Slide; Small Business Technology Transfer Research; Specific qualifier value; Speed; Surface; Survival Rate; Synovial Fluid; Technology; Testing; Texture; Theoretical model; Utah; Variant; analog; base; combat; cost; design; disability; experience; improved; knee replacement arthroplasty; melting; particle; pressure; research study; success; tool

DESCRIPTION (provided by applicant): Each year in the US, approximately 600,000 total knee replacement (TKR) surgeries are performed at a total annual cost of $15B and nearly 4.5M Americans are currently living with a TKR implant. The survival rate of TKR devices declines dramatically after ten years of use due primarily to mechanical wear. The objective of this STTR project is radically improve the durability of TKRs by modifying them to enhance the performance of the lubricating synovial fluid. The current paradigm for combating implant wear is to minimize friction by employing ultra-smooth sliding surfaces. In contrast, our approach will add to the implant's femoral component a surface texture that is designed to create hydrodynamic lubrication at low sliding velocities. Newly available ultra short pulse lasers will b used to create the designed texture on a CoCr femoral component in the form of arrays of micron-scale dimples. The lasers will achieve this in a manner that does not adversely affect the surface roughness between dimples, or the intrinsically excellent wear properties of the material. This Phase 1 project will verify the hypothesis that a surface so textured can generate full fluid lubrication at realistic knee joint sliding velocities to reduce friction and wear that eventually lead to implant failure. This research has the potential to shift current paradigms about implant bearing surfaces. This knowledge could produce a new generation of radically different, longer-lasting orthopedic implants. The method laser texturing method for modifying the implants is an established industrial process that is affordable and will allow near term transition of the lubrication enhancement technology for the benefit of patients and overall savings to the health care system.

描述（由申请人提供）：美国每年进行约60万例全膝关节置换（TKR）手术，年总成本为150亿美元，目前有近450万美国人使用TKR植入物。TKR器械的存活率在使用10年后急剧下降，主要原因是机械磨损。该STTR项目的目标是通过修改TKR以增强润滑滑液的性能，从根本上提高TKR的耐久性。目前对抗植入物磨损的范例是通过采用超光滑滑动表面来最大限度地减少摩擦。相比之下，我们的方法将为植入物的股骨部件添加表面纹理，旨在在低滑动速度下产生流体动力润滑。新推出的超短脉冲激光器将用于在CoCr股骨部件上以微米级凹痕阵列的形式创建设计纹理B。激光器将以不会对凹坑之间的表面粗糙度或材料固有的优异磨损性能产生不利影响的方式实现这一点。该第1阶段项目将验证这样的假设，即纹理化表面可以在真实的膝关节滑动速度下产生全流体润滑，以减少最终导致植入物失效的摩擦和磨损。这项研究有可能改变目前关于种植体支承表面的范式。这些知识可以产生新一代完全不同的，更持久的骨科植入物。用于修改植入物的激光纹理化方法是一种成熟的工业过程，价格实惠，并且将允许润滑增强技术的短期过渡，以使患者受益，并为医疗保健系统节省整体费用。