Bone quality by vQCT and HR-pQCT: translation to multi-center clinical research

vQCT 和 HR-pQCT 骨质量：转化为多中心临床研究

• 批准号: 8514530
• 负责人: Andrew John Burghardt
• 金额: $ 47.08万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514530
• 关键词: Accounting; Address; Apple; Architecture; Area; Biological Markers; Bone Density; Calibration; Clinic; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Communities; Computer software; Data; Development; Diagnostic radiologic examination; Elements; Engineering; Ensure; Environment; Etiology; Fracture; Functional disorder; Future; Goals; High Resolution Computed Tomography; Image; Image Analysis; Intervention; Joints; Leadership; Manufacturer Name; Maps; Measures; Methodology; Methods; Metric; Modeling; Multicenter Studies; Multicenter Trials; Nature; Osteoporosis; Patients; Peripheral; Pharmaceutical Preparations; Pharmacologic Substance; Phase III Clinical Trials; Plug-in; Process; Research; Research Project Grants; Resolution; Risk; Scanning; Site; Skeleton; Source; Standardization; Structure; Surrogate Markers; System; Therapeutic; Thick; Tomography, Computed, Scanners; Translations; Treatment Efficacy; United States National Institutes of Health; Variant; Visit; Work; X-Ray Computed Tomography; base; bone; bone geometry; bone quality; bone strength; cone-beam computed tomography; cost; density; human data; imaging modality; improved; in vivo; innovation; interest; method development; open source; osteoporosis with pathological fracture; programs; research study; skeletal; substantia spongiosa; tool; two-dimensional

DESCRIPTION (provided by applicant): Over the last decade, quantitative computed tomography (QCT) and volumetric QCT (vQCT) images have become important sources of quantitative information on cortical and trabecular bone density, bone geometry and whole bone strength in the central skeleton. Compartmental bone micro-architecture and strength in the peripheral skeleton are being obtained using newly deployed high-resolution peripheral QCT (HR-pQCT) scanners. Although these approaches are in wide use, their inherent value as clinical research tools will depend on two major factors: (i) the ability to seamlessly employ them in the multi-center setting and (ii) the ability to distill fundamental information on pathophysiology and treatment efficacy through "apples to apples" comparisons of the cohort studies and pharmacologic trials done thus far, a process hindered by the use of multiple scanner types and image analysis platforms. To address these two basic issues, we propose an innovative research program to establish metrics for standardization of vQCT and HR-pQCT acquisitions for future multi-center studies, as well as to provide standardized skeletal density and structural metrics to provide a basis for direct comparison across multiple cohort studies and clinical trials. This work will be carried out at UCSF under the joint direction of Drs Lang and Burghardt and at the Mayo Clinic under the leadership of Dr. Khosla and Dr. Keyak at UCI. This research program is embodied in the following specific aims: Specific Aim 1: Development of metrics to standardize QCT and HRpQCT acquisitions and analysis in multicenter studies. Specific Aim 2: Development of open-source image analysis metrics for vQCT incorporated as a plug-in NIH supported programs such as MIPAV.

描述（由申请人提供）：在过去十年中，定量计算机断层扫描（QCT）和容积QCT（vQCT）图像已成为中央骨骼中皮质骨和松质骨密度、骨几何形状和全骨强度定量信息的重要来源。使用新部署的高分辨率外周QCT（HR-pQCT）扫描仪获得外周骨骼中的间室骨微结构和强度。虽然这些方法被广泛使用，但它们作为临床研究工具的内在价值将取决于两个主要因素：（i）能够在多中心环境中无缝地使用它们，以及（ii）能够通过迄今为止进行的队列研究和药理学试验的“苹果对苹果”比较来提取关于病理生理学和治疗功效的基本信息，该过程受到多种扫描仪类型和图像分析平台的使用的阻碍。为了解决这两个基本问题，我们提出了一个创新的研究计划，以建立标准化的vQCT和HR-pQCT采集的指标，为未来的多中心研究，以及提供标准化的骨骼密度和结构指标，为多个队列研究和临床试验的直接比较提供基础。这项工作将在朗博士和伯格哈特博士的联合指导下在加州大学旧金山分校进行，并在UCI的科斯拉博士和基亚克博士的领导下在马约诊所进行。该研究计划体现在以下具体目标中：具体目标1：制定标准，以标准化多中心研究中的QCT和HRpQCT采集和分析。具体目标2：为vQCT开发开源图像分析指标，作为NIH支持的程序（如MIPAV）的插件。