类风湿关节炎中的宫颈发育不良和人乳头瘤病毒感染。-猫眼课题宝

类风湿关节炎中的宫颈发育不良和人乳头瘤病毒感染。

批准号：

8598638

负责人：

Seoyoung Catherine Kim

金额：

$0.09万

依托单位：

BRIGHAM AND WOMEN'S HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2010

资助国家：

美国

项目状态：

已结题

起止时间：

2010-08-01 至 2015-07-31

来源：

https://reporter.nih.gov/project-details/8598638

关键词：

Academic Medical Centers Address Adherence Algorithms Anogenital Human Papilloma Virus Infection Antirheumatic Agents Behavioral Biological Response Modifier Therapy Cervical Cancer Screening Cervical cancer vaccine Cervical dysplasia Chronic Clinical Clinical Sciences Clinical Trials Computerized Medical Record Data Data Sources Databases Disease Disease-Modifying Second-Line Drugs Drug usage Enrollment Environment Equipment Etanercept Faculty Female General Population Goals Guidelines Health Insurance Herpesvirus Type 3 High Risk Woman Hospitals Human Papillomavirus Human papilloma virus infection Hypersensitivity Immunocompromised Host Immunology Immunosuppressive Agents Incidence Infection Inflammatory Insurance Lead Life Malignant Neoplasms Malignant neoplasm of cervix uteri Methodology Oncogenic Opportunistic Infections Outcome Patients Pharmaceutical Economics Pharmaceutical Preparations Pharmacoepidemiology Postdoctoral Fellow Premalignant Registries Research Research Personnel Resources Rheumatism Rheumatoid Arthritis Rheumatology Risk Risk Factors Safety Severity of illness Sexually Transmitted Diseases Surrogate Endpoint Surveys Systemic Lupus Erythematosus Systemic Scleroderma Testing Therapeutic immunosuppression Time Training Tumor Necrosis Factor-alpha Ulcerative Colitis Vaccines Virus Woman adalimumab administrative database career clinical care infliximab inhibitor/antagonist patient oriented research patient registry prospective public health relevance rheumatologist rituximab tositumomab trend

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中文摘要

翻译

描述（由申请人提供）：我是Brigham and Women's Hospital（BWH）药物流行病学和药物经济学部门以及流变学、免疫学和过敏学部门的一名流变学家和博士后研究员，在丹尼尔H.所罗门和塞巴斯蒂安施内维斯。我的长期目标是建立一个职业生涯作为一个独立的药物流行病学研究与专业知识的安全性药物用于风湿性疾病。以前的研究表明，患有免疫功能低下疾病的妇女，包括系统性红斑狼疮，系统性硬化症和溃疡性结肠炎，患宫颈发育不良和人乳头瘤病毒（HPV）感染的风险比一般人群中的妇女更大。然而，关于类风湿性关节炎（RA）中宫颈发育不良和HPV感染的风险的数据很少。我建议使用几种综合方法来评估RA患者宫颈不典型增生、宫颈癌和HPV感染的风险，将这些结果的风险与不同类型的免疫抑制治疗（即，传统的缓解疾病的抗风湿药物与生物治疗）以及人口统计学和其他临床因素，并检查RA患者对当前宫颈癌筛查指南的依从性。我将使用不同的数据源，包括电子病历、大型管理数据库、患者调查以及患者登记。随着宫颈癌疫苗的出现，识别高危妇女对预防宫颈癌有着重要意义。

英文摘要

DESCRIPTION (provided by applicant): I am a Rheumatologist and Postdoctoral Fellow in the Division of Pharmacoepidemiology and Pharmacoeconomics and the Division of Rheumatology, Immunology and Allergy at Brigham and Women's Hospital (BWH), undertaking a training in Pharmacoepidemiology in the rheumatic diseases under the guidance of Drs. Daniel H. Solomon and Sebastian Schneeweiss. My long term goal is to establish a career as an independent pharmacoepidemiology researcher with expertise in the safety of drugs used in the rheumatic diseases. Previous studies have suggested that women with immunocompromised conditions including systemic lupus erythematosus, systemic sclerosis and ulcerative colitis are at a greater risk for cervical dysplasia and human papillomavirus (HPV) infection than are women in the general population. However, scant data exist regarding the risk of cervical dysplasia and HPV infection in rheumatoid arthritis (RA). I propose to use several integrative approaches to evaluate the risk of cervical dysplasia, cervical cancer and HPV infection in patients with RA, to relate the risks of these outcomes to different types of immunosuppressive therapy (i.e., traditional disease-modifying anti-rheumatic drugs versus biologic therapy) as well as demographic and other clinical factors and to examine adherence to current cervical cancer screening guidelines in patients with RA. I will be using different data sources including electronic medical records, large administrative databases, patient survey, as well as patient registries. With the advent of the cervical cancer vaccine, identification of women at high risk carries great

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