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Cervical Dysplasia and Human Papillomavirus Infection in Rheumatoid Arthritis.

类风湿关节炎中的宫颈发育不良和人乳头瘤病毒感染。

基本信息

批准号：
8701235
负责人：
Seoyoung Catherine Kim
金额：
$ 13.57万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8701235
关键词：
Academic Medical Centers Address Adherence Algorithms Anogenital Human Papilloma Virus Infection Antirheumatic Agents Behavioral Biological Response Modifier Therapy Cervical Cancer Screening Cervical cancer vaccine Cervical dysplasia Chronic Clinical Clinical Sciences Clinical Trials Computerized Medical Record Data Data Sources Databases Disease Disease-Modifying Second-Line Drugs Drug usage Enrollment Environment Equipment Etanercept Faculty Female General Population Goals Guidelines Health Insurance Herpesvirus Type 3 High Risk Woman Hospitals Human Papillomavirus Human papilloma virus infection Hypersensitivity Immunocompromised Host Immunology Immunosuppressive Agents Incidence Infection Inflammatory Insurance Lead Life Malignant Neoplasms Malignant neoplasm of cervix uteri Methodology Oncogenic Opportunistic Infections Outcome Patients Pharmaceutical Economics Pharmaceutical Preparations Pharmacoepidemiology Postdoctoral Fellow Premalignant Registries Research Research Personnel Resources Rheumatism Rheumatoid Arthritis Rheumatology Risk Risk Factors Safety Severity of illness Sexually Transmitted Diseases Surrogate Endpoint Surveys Systemic Lupus Erythematosus Systemic Scleroderma Testing Therapeutic immunosuppression Time Training Tumor Necrosis Factor-alpha Ulcerative Colitis Vaccines Virus Woman adalimumab administrative database career clinical care infliximab inhibitor/antagonist patient oriented research patient registry prospective public health relevance rheumatologist rituximab tositumomab trend

项目摘要

DESCRIPTION (provided by applicant): I am a Rheumatologist and Postdoctoral Fellow in the Division of Pharmacoepidemiology and Pharmacoeconomics and the Division of Rheumatology, Immunology and Allergy at Brigham and Women's Hospital (BWH), undertaking a training in Pharmacoepidemiology in the rheumatic diseases under the guidance of Drs. Daniel H. Solomon and Sebastian Schneeweiss. My long term goal is to establish a career as an independent pharmacoepidemiology researcher with expertise in the safety of drugs used in the rheumatic diseases. Previous studies have suggested that women with immunocompromised conditions including systemic lupus erythematosus, systemic sclerosis and ulcerative colitis are at a greater risk for cervical dysplasia and human papillomavirus (HPV) infection than are women in the general population. However, scant data exist regarding the risk of cervical dysplasia and HPV infection in rheumatoid arthritis (RA). I propose to use several integrative approaches to evaluate the risk of cervical dysplasia, cervical cancer and HPV infection in patients with RA, to relate the risks of these outcomes to different types of immunosuppressive therapy (i.e., traditional disease-modifying anti-rheumatic drugs versus biologic therapy) as well as demographic and other clinical factors and to examine adherence to current cervical cancer screening guidelines in patients with RA. I will be using different data sources including electronic medical records, large administrative databases, patient survey, as well as patient registries. With the advent of the cervical cancer vaccine, identification of women at high risk carries great

描述（由申请人提供）：我是美国布莱根妇女医院（BWH）药物流行病学与药物经济学学部和风湿病、免疫与过敏学部的风湿病学家和博士后，在布里格姆妇女医院（BWH）风湿病、免疫与过敏学博士的指导下进行风湿病药物流行病学培训。Daniel H. Solomon和Sebastian Schneeweiss。我的长期目标是成为一名独立的药物流行病学研究人员，在风湿性疾病中使用的药物安全性方面具有专业知识。先前的研究表明，与普通人群相比，患有系统性红斑狼疮、系统性硬化症和溃疡性结肠炎等免疫功能低下疾病的女性患宫颈发育不良和人乳头瘤病毒（HPV）感染的风险更大。然而，关于类风湿性关节炎（RA）中宫颈发育不良和HPV感染的风险的数据很少。我建议使用几种综合方法来评估RA患者宫颈发育不良、宫颈癌和HPV感染的风险，将这些结果的风险与不同类型的免疫抑制治疗（即传统的改善疾病的抗风湿药物与生物治疗）以及人口统计学和其他临床因素联系起来，并检查RA患者对当前宫颈癌筛查指南的依从性。我将使用不同的数据源，包括电子病历、大型管理数据库、患者调查以及患者登记。随着宫颈癌疫苗的问世，对高危妇女的识别意义重大

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Patients' perception about risks and benefits of antithrombotic treatment for the prevention of venous thromboembolism (VTE) after orthopedic surgery: a qualitative study.

DOI：
10.1186/s12891-015-0777-x
发表时间：
2015-10-26
期刊：
BMC musculoskeletal disorders
影响因子：
2.3
作者：
Najafzadeh M;Kim SC;Patterson C;Schneeweiss S;Katz JN;Brick GW;Ready JE;Polinski JM;Patorno E
通讯作者：
Patorno E

Patterns of bisphosphonates utilization in patients under age 45 in a large cohort of commercial insurance beneficiaries in the United States.

美国一大群商业保险受益人中 45 岁以下患者的双磷酸盐使用模式。