The Impact of Treatment Adherence on A Clinical Biomarker in Pediatric Acute Lymp

描述(由申请人提供)：候选人詹妮弗·罗翰女士是辛辛那提大学临床健康心理学博士项目的二年级研究生，重点是儿科心理学。她在辛辛那提儿童医院医疗中心教授兼治疗依从性中心主任丹尼斯·多罗塔尔博士的指导下工作。[赞助者和共同赞助者指导团队是根据他们在与应用程序相关的关键领域的内容专业知识以及Rohans女士与Vinks1博士和Rausch博士在各种研究项目上的合作而选择的。Perentesis博士(CCHMC的肿瘤学家/血液肿瘤科主任)和Huang博士(生物统计学家)被选为Rohan女士的顾问/导师，以分别获得儿科癌症和ALL以及先进的数据分析方法方面的专业培训。拟议的培训计划包括以下方面的培训机会：儿科癌症、研究道德、高级统计技术、与治疗依从性有关的药理学和研究方法，以及[在一系列慢性病中对儿科依从性的全面临床管理]。拟议的培训方案将促进论文分析，这些分析将检查治疗依从性的[预测因素]，[包括]治疗状况和心理社会因素。这些机会将促进罗翰女士作为[儿科心理学]研究员的职业发展，并促进她的职业潜力[进行儿科癌症研究以及 其他慢性病人群]。罗翰的长期职业目标是在儿科医学中心和/或大学学术环境中获得一个专注于研究的终身教职教师职位，并在儿科慢性病，特别是儿科癌症的背景下进行研究，调查治疗依从性和自我管理。[应当指出，本研究中正在使用的拟议测量计划和数据分析策略对其他慢性病具有广泛的适用性和普适性。As1evidenced1by1Ms1Rohans1training1to1date¿1she1对一系列慢性疾病感兴趣，并计划在她的职业生涯中与许多疾病人群合作]。拟议的NRSA博士前奖学金(F31)将在7-18岁被诊断为急性淋巴细胞白血病的儿童和青少年(N=138)样本中调查对每日化疗药物的治疗依从性。拟议的项目是使用从目前由国家癌症研究所资助的正在进行的父母研究中收集的数据进行的二次数据分析(PI：Drotar；R01 CA119162)。应该指出的是，在这项NRSA中提出的拟议研究并不是更大的母体研究的主要或次要目标的一部分。这项拟议的研究涉及一种新的数据分析策略，如果不是1MS1Rohans 1Interest 1in1结合两种客观的治疗依从性方法(行为/药物)来预测临床结果(中性粒细胞绝对计数：ANC)，则不会进行该策略。父母研究样本对于建议的数据分析策略是理想的，这些策略需要100个或更多参与者的样本，否则无法使用一个站点。

DESCRIPTION (provided by applicant): The candidate, Ms. Jennifer Rohan, is a second-year graduate student in the Clinical Health Psychology doctoral program with an emphasis in Pediatric Psychology at the University of Cincinnati. She is working under the mentorship of Dr. Dennis Drotar, Professor and Director of the Center for Treatment Adherence at Cincinnati Children's Hospital Medical Center. [The sponsor and co-sponsor mentorship team was chosen based on their content expertise in key areas related to the application as well as Ms. Rohans collaboration with Drs. Vinks1and Rausch on various research projects. Drs. Perentesis (Oncologist/Director of Hematology-Oncology at CCHMC) and Huang (Biostatistician) were chosen as consultants/mentors for Ms. Rohan to gain specialized training in pediatric cancer and ALL as well as advanced data analytic methods respectively]. The proposed training plan includes opportunities for training in pediatric cancer, research ethics, advanced statistical techniques, pharmacological and research methods related to treatment adherence, and [comprehensive clinical management of pediatric adherence in a range of chronic conditions]. The proposed training proposal will facilitate dissertation analyses that will examine [predictors of] treatment adherence, [including] treatment status, and psychosocial factors. These opportunities will facilitate Ms. Rohan's professional development as a [pediatric psychology] researcher, and facilitate her career potential [to conduct research in pediatric cancer as well as other chronic illness populations]. Ms. Rohan's long-term career goal is to obtain a research-focused tenure-track faculty position in a pediatric medical center and/or university academic setting and conduct research investigating treatment adherence and self-management in the context of pediatric chronic illness, specifically pediatric cancer. [It should be noted that the proposed measurement plan and data analytic strategy being used in the current study has broad applicability and generalizability to other chronic conditions. As1evidenced1by1Ms1Rohans1training1to1date¿1she1 is interested in a broad range of chronic conditions and plans to work with a number of disease populations in her career]. The proposed NRSA predoctoral fellowship (F31) will investigate treatment adherence to a daily chemotherapy medication in a sample of children and adolescents (N = 138) ages 7-18 years diagnosed with acute lymphoblastic leukemia. The proposed project is a secondary data analysis using data collected from an ongoing parent study currently funded by the National Cancer Institute (PI: Drotar; R01 CA119162). It should be noted that the proposed research presented in this NRSA was not a part of the primary or secondary aims of the larger parent study. The proposed study involves a new data analytic strategy that would not have otherwise been conducted if not1for1Ms1Rohans 1interest1in1combining two objective methods of treatment adherence (behavioral/pharmacological) to predict a clinical outcome (absolute neutrophil count: ANC). The parent study sample is ideal for the proposed data analytic strategies that require samples of 100 or more participants and would not otherwise be available using one site.