The Impact of Treatment Adherence on A Clinical Biomarker in Pediatric Acute Lymp

描述（由申请人提供）：候选人Jennifer Rohan女士是辛辛那提大学临床健康心理学博士课程的二年级研究生，重点是儿科心理学。她在辛辛那提儿童医院医学中心治疗依从性中心的教授和主任Dennis Drotar博士的指导下工作。[赞助商和共同赞助商指导团队的选择是基于他们在与应用程序相关的关键领域的内容专业知识，以及Rohans女士与博士的合作。vinks1和Rausch的各种研究项目。Drs。Perentesis （CCHMC肿瘤学家/血液肿瘤学主任）和Huang（生物统计学家）被选为Rohan女士的顾问/导师，分别接受儿科癌症和ALL的专业培训以及先进的数据分析方法。拟议的培训计划包括儿科癌症、研究伦理、先进的统计技术、与治疗依从性相关的药理学和研究方法，以及[一系列慢性疾病中儿科依从性的综合临床管理]方面的培训机会。拟议的培训建议将促进论文分析，将检查治疗依从性的[预测因素]，[包括]治疗状态和心理社会因素。这些机会将促进Rohan女士作为[儿科心理学]研究人员的专业发展，并促进她的职业潜力[进行儿科癌症研究]以及

DESCRIPTION (provided by applicant): The candidate, Ms. Jennifer Rohan, is a second-year graduate student in the Clinical Health Psychology doctoral program with an emphasis in Pediatric Psychology at the University of Cincinnati. She is working under the mentorship of Dr. Dennis Drotar, Professor and Director of the Center for Treatment Adherence at Cincinnati Children's Hospital Medical Center. [The sponsor and co-sponsor mentorship team was chosen based on their content expertise in key areas related to the application as well as Ms. Rohans collaboration with Drs. Vinks1and Rausch on various research projects. Drs. Perentesis (Oncologist/Director of Hematology-Oncology at CCHMC) and Huang (Biostatistician) were chosen as consultants/mentors for Ms. Rohan to gain specialized training in pediatric cancer and ALL as well as advanced data analytic methods respectively]. The proposed training plan includes opportunities for training in pediatric cancer, research ethics, advanced statistical techniques, pharmacological and research methods related to treatment adherence, and [comprehensive clinical management of pediatric adherence in a range of chronic conditions]. The proposed training proposal will facilitate dissertation analyses that will examine [predictors of] treatment adherence, [including] treatment status, and psychosocial factors. These opportunities will facilitate Ms. Rohan's professional development as a [pediatric psychology] researcher, and facilitate her career potential [to conduct research in pediatric cancer as well as other chronic illness populations]. Ms. Rohan's long-term career goal is to obtain a research-focused tenure-track faculty position in a pediatric medical center and/or university academic setting and conduct research investigating treatment adherence and self-management in the context of pediatric chronic illness, specifically pediatric cancer. [It should be noted that the proposed measurement plan and data analytic strategy being used in the current study has broad applicability and generalizability to other chronic conditions. As1evidenced1by1Ms1Rohans1training1to1date¿1she1 is interested in a broad range of chronic conditions and plans to work with a number of disease populations in her career]. The proposed NRSA predoctoral fellowship (F31) will investigate treatment adherence to a daily chemotherapy medication in a sample of children and adolescents (N = 138) ages 7-18 years diagnosed with acute lymphoblastic leukemia. The proposed project is a secondary data analysis using data collected from an ongoing parent study currently funded by the National Cancer Institute (PI: Drotar; R01 CA119162). It should be noted that the proposed research presented in this NRSA was not a part of the primary or secondary aims of the larger parent study. The proposed study involves a new data analytic strategy that would not have otherwise been conducted if not1for1Ms1Rohans 1interest1in1combining two objective methods of treatment adherence (behavioral/pharmacological) to predict a clinical outcome (absolute neutrophil count: ANC). The parent study sample is ideal for the proposed data analytic strategies that require samples of 100 or more participants and would not otherwise be available using one site.