In Vivo Analysis of Stationary Gas Filled Hollow Iron Doped Silica Nanoshells

描述（由申请人提供）：背景：癌症的手术切除变得越来越微创，切口更小，患者发病率更低。然而，这一过程将负担转移到外科医生身上，以在次优可视化的情况下去除所有疾病。本项目拟开发一种技术，采用术前注射超声造影增强固定微泡和微/[纳米]壳，即使在皮肤切口较小的情况下也能在术中检测肿瘤，从而使外科医生能够更好地识别和完全切除肿瘤，降低患者发病率。目的：确定静态微泡作为超声造影剂在兔模型中的最佳剂量和寿命，以定位小的乳腺肿瘤进行手术切除。为了研究一种新型的气体填充的二氧化硅微/[纳米]壳的定位能力，与微泡相比， 超声造影剂和定位方法用于兔隐匿性乳腺癌模型。结论：小的早期癌症的手术切除在局部控制和预防转移方面仍然很重要，提高其在可视化和完全切除肿瘤方面的疗效的技术可以对乳腺癌和其他癌症的治疗产生重大影响。由于无法在手术期间检测到这些肿瘤，因此改善不可触及癌症的定位和可视化至关重要。在这个通过成像检测微小癌症并且需要更先进的技术来定位肿瘤的时代，这一事实尤其重要。该项目可能能够减少阳性边缘，局部复发和早期癌症的可能治愈。

DESCRIPTION (provided by applicant): Background: Surgical resection for cancer is becoming more minimally invasive with smaller incisions and less patient morbidity. However, this process switches the burden to the surgeon to remove all the disease with suboptimal visualization. This project proposes to develop a technique to employ preoperative injection of ultra- sound contrast enhancement stationary microbubbles and micro/[nano]shells to enable intraoperative detection of tumors even in cases with small skin incisions to allow surgeons to better identify and completely resect tumors and decease patient morbidity. Aims: To determine the optimal dose and lifetime of stationary microbubbles in a rabbit model as an ultrasound contrast agent in order to localize small breast tumors for surgical resection. To study the localization ability of a novel gas filled silica micro/[nano]shells compared to microbubbles as an ultrasound contrast agent and localization method for occult breast cancers using a rabbit model. Conclusion: Surgical resection of small early cancers remains important in local control and prevention of metastases, techniques to improve its efficacy in visualizing and removing tumors completely can have a major impact on breast and other cancer treatment. It is critical to improve the localization and visualization of non- palpable cancers due to the inability to detect these tumors during surgery. This fact is particularly important in this era in which tiny cancers are detected by imaging and more advanced techniques are needed for localizing tumors. This project may be able to decrease positive margins, local recurrence and possible cure of early stage cancers.