Influence of moderate hearing loss on auditory perception & cortical processing

中度听力损失对听觉感知的影响

• 批准号: 8523187
• 负责人: Dan Harvey Sanes
• 金额: $ 29.22万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8523187
• 关键词: ARHGEF5 gene; Acoustics; Address; Adolescence; Adolescent; Adult; Affect; Animals; Auditory; Auditory Perception; Auditory area; Behavior; Behavioral; Brain; Child; Code; Communication; Conductive hearing loss; Control Animal; Cues; Data; Data Analyses; Detection; Development; Frequencies; Gerbils; Goals; Hearing; Human; Individual; Laboratories; Language Development; Lead; Measurable; Measures; Metric; Nervous System Physiology; Neuraxis; Neurons; Operant Conditioning; Pattern; Perception; Performance; Process; Property; Proteinase 3; ST5 gene; Sensorineural Hearing Loss; Sensory; Shapes; Signal Transduction; Stimulus; Structure; Synaptic Membranes; Testing; Time; Training; Work; awake; base; ear infection; early experience; experience; hearing impairment; improved; juvenile animal; middle ear; neurodevelopment; relating to nervous system; response; skills; sound; theories

PROJECT SUMMARY Many auditory perceptual skills mature over a long time course (in humans), well into the teenage years. If hearing is disrupted during development, there may be long-lasting deficits in auditory perception and language acquisition. Surprisingly, maturation of the auditory coding properties that support late-emerging perceptual skills are largely unknown; what little we do know is based solely on recordings from anesthetized animals. This is also why our understanding of the effect of mild to moderate hearing loss on central auditory maturation is unsettled. To address these issues, I will examine functional development in awake animals for the first time, and explore how auditory coding properties are influenced by sensory experience. The central hypothesis is that moderate hearing loss during development disrupts coding properties in the auditory cortex (ACx), leading to measurable deficits in auditory perceptual performance. There are three related aims: AIM 1 will determine whether developmental conductive hearing loss disrupts the perceptual abilities of adult gerbils. Animals will be tested on two tasks that, in humans, are known to have different rates of maturation and to be affected by hearing loss. These include detection of sinusoidal amplitude (sAM) and frequency modulated (sFM) signals. AIM 2 will determine whether training on an auditory task during juvenile development can rescue normal perceptual behavior in animals reared with conductive hearing loss. AIM 3 will characterize the normal rate of development of neural coding properties underlying the percepts examined in Aim 1, and will assess whether these coding properties are perturbed in a manner that correlates with perceptual deficits examined in AIM 1. Single unit recordings will be obtained from the ACx of awake animals during the period of development that follows cochlear maturation. The broad goals are to determine whether coding properties mature at different rates, as suggested by behavioral studies, and to determine whether sAM or sFM coding is vulnerable to early hearing loss. Together, these data will provide the first analysis of auditory coding in awake developing animals, and reveal whether moderate hearing loss disrupts both perceptual skills and the coding properties that support them.

项目概要 许多听觉感知技能经过很长一段时间（人类）的成熟，一直到青少年时期。如果 听力在发育过程中受到干扰，听觉感知和听觉方面可能会出现长期缺陷 语言习得。令人惊讶的是，支持后发的听觉编码特性的成熟 知觉技能很大程度上是未知的；我们所知甚少，仅基于麻醉后的录音 动物。这也是为什么我们理解轻中度听力损失对中枢听觉的影响 成熟度不稳定。为了解决这些问题，我将检查清醒动物的功能发育 第一次，探索感官体验如何影响听觉编码特性。中央 假设是发育过程中的中度听力损失会破坏听觉皮层的编码特性 （ACx），导致听觉感知表现可测量的缺陷。共有三个相关目标： AIM 1 将确定发育性传导性听力损失是否会扰乱成年沙鼠的感知能力。 动物将接受两项任务的测试，已知这两项任务在人类中具有不同的成熟速度，并且 受到听力损失的影响。其中包括检测正弦幅度 (sAM) 和频率调制 (sFM) 信号。 AIM 2 将确定青少年发育期间听觉任务的训练是否可以 挽救患有传导性听力损失的动物的正常知觉行为。 AIM 3 将表征 目标 1 中检查的感知基础的神经编码特性的正常发展速率，并将 评估这些编码属性是否以与感知缺陷相关的方式受到干扰 在 AIM 1 中进行检查。将从清醒动物的 ACx 中获得单个单位记录。 耳蜗成熟后的发育。主要目标是确定编码属性是否 根据行为研究的结果，以不同的速率成熟，并确定 sAM 或 sFM 编码是否适用 容易出现早期听力损失。这些数据将共同提供对清醒状态下听觉编码的首次分析 发育中的动物，并揭示中度听力损失是否会破坏感知技能和编码 支持它们的属性。

项目成果

Prolonged maturation of auditory perception and learning in gerbils.

在沙鼠中，听觉感知和学习的长期成熟。

• DOI: 10.1002/dneu.20801
• 发表时间: 2010-08
• 期刊: DEVELOPMENTAL NEUROBIOLOGY
• 影响因子: 3
• 作者: Sarro, Emma C.;Sanes, Dan H.
• 通讯作者: Sanes, Dan H.

Effects of spectral and temporal disruption on cortical encoding of gerbil vocalizations.

频谱和时间干扰对沙鼠发声皮质编码的影响。

• DOI: 10.1152/jn.00645.2012
• 发表时间: 2013
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Ter-Mikaelian,Maria;Semple,MalcolmN;Sanes,DanH
• 通讯作者: Sanes,DanH

The cost and benefit of juvenile training on adult perceptual skill.

• DOI: 10.1523/jneurosci.6137-10.2011
• 发表时间: 2011-04-06
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Sarro EC;Sanes DH
• 通讯作者: Sanes DH

Auditory training during development mitigates a hearing loss-induced perceptual deficit.

• DOI: 10.3389/fnsys.2014.00049
• 发表时间: 2014
• 期刊: Frontiers in systems neuroscience
• 影响因子: 3
• 作者: Kang R;Sarro EC;Sanes DH
• 通讯作者: Sanes DH

Few juvenile auditory perceptual skills correlate with adult performance.

青少年的听觉感知技能很少与成人的表现相关。

• DOI: 10.1037/a0035516
• 发表时间: 2014
• 期刊: Behavioral neuroscience
• 影响因子: 1.9
• 作者: Sarro,EmmaC;Sanes,DanH
• 通讯作者: Sanes,DanH