Development of ROR ligands for treatment of circadian rhythm disorders

描述(申请人提供)：核激素受体超家族(NHR)和配体调节的转录因子，已被证明是针对多种人类疾病的药物开发的丰富靶点来源。视黄酸受体相关的孤儿受体(RORs)是这个超家族的成员，调节着包括昼夜节律、新陈代谢和免疫反应在内的多个生理过程。我们最近确定了第一个针对ROR的选择性合成配体，ROR是昼夜节律的关键调节因子。我们的长期目标是开发针对RORs的配体，可用于治疗与昼夜节律失调相关的疾病，如躁郁症、睡眠障碍以及精神分裂症。最初的先导化合物(T0901317)作为靶向ROR的药物的性能不佳，我们的初步数据表明，我们可以显着改善其类药物性能。我们假设，基于T0901317化学支架的优化的ROR配体具有更好的药效学、药代动力学和受体选择性特性，将有效地调节昼夜节律。为了解决这一假设，我们将专注于以下具体目标：1)开发和优化针对中枢神经系统的具有改进的药代动力学和药效学特性的ROR配体；2)表征ROR配体对动物昼夜节律的作用。我们预测，这项研究将提供调节ROR1活性的新颖、创新的配体，这将具有潜在的实用价值，用于治疗睡眠障碍以及其他与昼夜节律失调相关的疾病，包括生物极化障碍和精神分裂症。

DESCRIPTION (provided by applicant): The nuclear hormone receptor superfamily (NHR) and ligand regulated transcription factors that have proven to be a rich source of targets for development of drugs that target myriad human diseases. The retinoic acid receptor-related orphan receptors (RORs) are members of this superfamily and regulate several physiological processes including the circadian rhythm, metabolism and the immune response. We recently identified the first selective synthetic ligands that target ROR, a critical regulator of the circadian rhythm. Our long-term goal is to develop ligands targeting RORs that can be used to treat diseases associated with dysregulation of the circadian rhythm such as bipolar and sleep disorders as well as schizophrenia. The initial lead compound (T0901317) has less than optimal properties for use as a drug targeting ROR and our preliminary data indicates that we can significantly improve its drug like properties. We hypothesize that optimized ROR ligands, based on the T0901317 chemical scaffold, with improved pharmacodynamic, pharmacokinetic, and receptor selectivity properties will have efficacy in modulation of the circadian rhythm. In order to address this hypothesis we will focus on the following specific aims: 1) Develop and optimize ROR ligands with improved pharmacokinetic and pharmacodynamic properties targeting the central nervous system; 2) Characterize the actions of ROR ligands on the circadian rhythm in animals. We predict that this research will provide novel, innovative ligands that modulate ROR1 activity that will have potential utility to treat sleep disorders as well as other disorders associated with dysregulation of the circadian rhythm including biopolar disorder and schizophrenia.