Core Center-NIDCD Research Core Center P30

核心中心-NIDCD研究核心中心P30

• 批准号: 8528543
• 负责人: Stefan Heller
• 金额: $ 43.35万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-18 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528543
• 关键词: Animals; Auditory; Auditory Evoked Potentials; Auditory Physiology; Biomedical Engineering; Cell physiology; Cells; Collaborations; Development; Electrodes; Ensure; Equipment; Faculty; Funding; Goals; Head and Neck Surgery; Human Resources; Image; Knowledge; Laboratories; Life; Mammals; Measures; Molecular Neurobiology; National Institute on Deafness and Other Communication Disorders; Neurobiology; Otolaryngology; Preparation; Principal Investigator; Recovery; Research; Research Personnel; Research Support; Specialist; Speed; Supervision; Surface; System; Technology; Time; Training; Tympanometry; Work; base; cost efficient; fluorescence imaging; in vivo; interest; meetings; member; operation; otoacoustic emission; ranpirnase; sound; two-photon

DESCRIPTION (provided by applicant): The main goals of the Stanford OHNS Core Center are to serve 1) as a hub for knowledge and technology, 2) to stimulate and support collaborative research, and 3) to provide access to high quality state-of-the-art technology via cost efficient shared utilization of Core Center equipment among R01-funded laboratories. Administration of the Core Center will be provided by the Principal Investigator and two Research Core Directors in conjunction with an administrative assistant. The Core's administration is responsible for daily operations, but also for long-term planning with the overall objective to ensure that the main goals of the Core Center are being met. Two Research Cores are proposed: Core I - Imaging Core, consists of four independent imaging systems, each one individually dedicated for specific tasks including routine confocal and fluorescence imaging, two photon imaging, live cell confocal imaging, and high-speed live cell confocal imaging. A full time imaging specialist will support Core users with expert advice, training, and supervision. Core II - Auditory Function Core consists of dedicated apparatus development space, two sound shielded rooms, two adjacent rooms for animal preparations and recovery, and three comprehensive auditory physiology systems. These systems are dedicated to measures of auditory function in vivo in small mammals including tympanometry, otoacoustic emissions and auditory evoked potentials from surface or subdural electrodes. A part time auditory function specialist will support core users with expertise, training, and supervision. The imaging and auditory function equipment is already being used by a group of researchers that are faculty members in Otolaryngology - Head & Neck Surgery, Neurobiology, Molecular & Cellular Physiology, as well as Bioengineering. There already is an urgent need for support personnel and an overall core organization, which will ensure efficient shared use of the existing equipment by a highly collaborative user base that is unified by a common interest in auditory and vestibular neurobiology.

描述(由申请人提供)：斯坦福OHNS核心中心的主要目标是1)作为知识和技术的中心，2)刺激和支持合作研究，3)通过在R01资助的实验室之间经济高效地共享核心中心设备来提供获得高质量最先进技术的机会。 核心中心的行政管理将由首席调查员和两名研究核心主任以及一名行政助理提供。核心中心的行政部门负责日常运作，但也负责长期规划，总体目标是确保核心中心的主要目标得以实现。 提出了两个研究核心：核心I-成像核心，由四个独立的成像系统组成，每个成像系统分别专门用于特定任务，包括常规共焦和荧光成像、双光子成像、活细胞共焦成像和高速活细胞共焦成像。一名全职成像专家将为核心用户提供专家建议、培训和监督。核心II-听觉功能核心由专用设备开发空间、两个隔音室、两个相邻的动物准备和恢复室以及三个综合听觉生理系统组成。这些系统致力于测量小型哺乳动物体内的听觉功能，包括鼓室导纳、耳声发射和表面或硬膜下电极的听觉诱发电位。一名兼职听觉功能专家将为核心用户提供专业知识、培训和监督。 成像和听觉功能设备已经被一组研究人员使用，他们是耳鼻喉科-头颈外科、神经生物学、分子和细胞生理学以及生物工程的教员。已经迫切需要支助人员和一个全面的核心组织，这将确保高度协作的用户群有效地共享使用现有设备，该用户群因对听觉和前庭神经生物学的共同兴趣而统一起来。