BK Channels of Hair Cells
毛细胞的 BK 通道
基本信息
- 批准号:8448046
- 负责人:
- 金额:$ 35.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-07-01 至 2018-01-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAffectAgeAlternative SplicingAnimalsApicalBiochemicalBiological ModelsCDK5 geneCalciumCell LineCell membraneCell physiologyCellsCharacteristicsChickensCyclic AMP-Dependent Protein KinasesDataDiseaseEndosomesEpilepsyEpithelial CellsEpitheliumExonsFrequenciesFundingGolgi ApparatusHair CellsHearingHypertensionIndividualKineticsKnockout MiceLabelLateralMDCK cellMammalsMediatingMembraneMethodsMolecularMusOpticsOrganellesOuter Hair CellsOutputPathway interactionsPhosphorylationPhosphorylation SitePhosphotransferasesPhysiologicalPlayPotassiumPropertyProtein KinaseProteinsRNA SplicingRecyclingRoleS-nitro-N-acetylpenicillamineSmall Interfering RNASorting - Cell MovementStudy modelsSurfaceTestingTimeVertebratesbasebeta catenincholinergicdensityestablished cell linehearing impairmentinhibitor/antagonistlarge-conductance calcium-activated potassium channelsmutantpublic health relevancereceptorreconstitutionresponsetraffickingvectorvoltage
项目摘要
DESCRIPTION (provided by applicant): The proposal seeks to bring a molecular understanding of how large conductance calcium activated potassium (BK) channels, which are important for hearing affect hair cell function using mouse and chicken hair cells as a model system. The channels consist of the Slo protein and a variable number of associated proteins The proposal seeks to determine how BK channels are localized at the basolateral surface of hair cells. In particular the proposal seeks to ascertain how Slo trafficking in hair cells occur ad tests the hypothesis that Slo in hair cells uses the basolateral secretory pathway in polarized epithelial cells. The role of phosphorylation and associated proteins in bringing about basolateral sorting will be explored. The project will also determine how splicing, phosphorylation and Slo associated proteins affect BK kinetics attempting to relate these changes to those in native hair cells.
描述(由申请人提供):该提案试图以小鼠和鸡毛细胞为模型系统,对大电导钙激活钾(BK)通道如何影响毛细胞功能进行分子理解,BK通道对听力非常重要。通道由Slo蛋白和数量可变的相关蛋白组成,该提案试图确定BK通道是如何定位在毛细胞的基底外侧表面的。特别是,该提案试图确定Slo在毛细胞中的运输是如何发生的,并测试了毛细胞中的Slo使用极化上皮细胞的基侧分泌途径的假设。本课程将探讨磷酸化及相关蛋白质在实现基侧分选中的作用。该项目还将确定剪接、磷酸化和Slo相关蛋白如何影响BK动力学,试图将这些变化与天然毛细胞中的变化联系起来。
项目成果
期刊论文数量(0)
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DHASAKUMAR S NAVARATNAM其他文献
DHASAKUMAR S NAVARATNAM的其他文献
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