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Membrane properties of the OHC system

Membrane properties of the OHC system
OHC 系统的膜特性
批准号：
10632052
负责人：
DHASAKUMAR S NAVARATNAM
金额：
$67.24万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
未结题
起止时间：
2017-06-12 至 2027-05-31
来源：
https://reporter.nih.gov/project-details/10632052
关键词：
AffectAnionsAreaBehaviorBicarbonatesCell membraneChargeChloridesCholesterolCochleaComplementComputer SimulationContractsCrosslinkerCryoelectron MicroscopyCyclosporineCysteineDetergentsElectric CapacitanceEnvironmentFamilyFatty AcidsFree EnergyGoalsHearingHeightLateralLengthLipidsMammalsMeasurableMediatingMembraneMembrane LipidsMembrane PotentialsMembrane ProteinsMethodologyMethodsMicellesModelingMolecularMolecular ConformationMolecular MotorsMotorMovementMutationOuter Hair CellsPaperPathologyPathway interactionsPhysiologicalProcessPropertyProteinsResolutionSalicylic AcidsSamplingSeminalStructureSystemTemperatureTimeVesicleWorkcombatconformational conversionimage processingloss of functionmembermillisecondmolecular dynamicsmutantnanodiskpreservationprotein structurerat Pres proteinresponsesensorsingle moleculevoltage

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Project Summary In this proposal we hope to build on our efforts defining the cryoEM structure of prestin, the OHC lateral wall motor responsible for cochlear amplification, in the depolarized and contracted state. In this proposal we seek to define the protein's structure in the expanded state brought about by voltage. We will use complementary methods to determine its structure exploiting recent advances in image processing and using temperature and mutations that affect its violtage sensitivity. In addition, we will also be using modeling using molecular dynamics simulations to understand its structure under voltage control.
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Structural correlates of prestin activity
  • 批准号：
    10862035
  • 项目类别：
  • 资助金额：
    $71.18万
  • 财政年份：
    2023
  • 负责人：
    DHASAKUMAR S NAVARATNAM
  • 依托单位：
    YALE UNIVERSITY
Membrane properties of the OHC system
  • 批准号：
    10530793
  • 项目类别：
  • 资助金额：
    $70.24万
  • 财政年份：
    2017
  • 负责人：
    DHASAKUMAR S NAVARATNAM
  • 依托单位：
    YALE UNIVERSITY
Structural correlates of prestin activity.
  • 批准号：
    8212555
  • 项目类别：
  • 资助金额：
    $34.04万
  • 财政年份：
    2007
  • 负责人：
    DHASAKUMAR S NAVARATNAM
  • 依托单位：
    YALE UNIVERSITY
Structural correlates of prestin activity.
  • 批准号：
    8413439
  • 项目类别：
  • 资助金额：
    $32.34万
  • 财政年份：
    2007
  • 负责人：
    DHASAKUMAR S NAVARATNAM
  • 依托单位：
    YALE UNIVERSITY
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