Pilot Project

项目摘要：参与临床和预防研究的某些亚群的不成比例的低数量对科学结果的代表性产生重大影响，并导致社会和临床不公。(1)拉美裔是美国和纽约西部人口增长最快的群体之一，他们认为参加癌症筛查检查和志愿成为生物医学研究的研究参与者的风险水平同样高。(2) 这项提案将研究使水牛城的拉美裔人与罗斯威尔公园癌症研究所的科学家合作的战略，以增进彼此的了解和参与为癌症预防研究捐赠的生物标本，从而获得关于捐赠的生物标本类型(即唾液和/或血液)的变化的试点数据。我们将在现有伙伴关系的基础上，与500多名参加以社区为基础的乳腺癌和宫颈癌预防教育计划(研究标题：Eperanza y Vida)的拉丁裔男女队列建立合作伙伴关系，以解决以下具体目标：1)调查 布法罗拉丁裔社区代表的看法、知识和信念，以确定这些看法可能如何影响以Pata银行和生物储存库(PBBR)为重点的研究参与，2)开发一项试点社区友好干预措施，以提高拉美裔居民的知识、理解、意图和参与研究的重点，重点是参与PBBR，3)调查教育和招募拉丁裔妇女及其家庭参加生物医学研究的可行性和有效性 通过以社区为基础的方法和干预措施，通过出席、调查和参与研究来衡量埃斯佩兰扎y Vida研究队列内的研究捐赠。TIIS的研究结果有望确定参与当地拉美裔社区研究的具体障碍、挑战和资产； 以及研究机构和社区合作伙伴招募、积累和分析与癌症研究相关的措施所需的技术便利。这可以产生具体的可检验的研究假设，为未来的环境流行病学CBPR研究提供潜力，并为围绕研究项目建设拉美裔社区的能力提供指导方针和基础。

Project Summary: The disproportionately lower number of certain subpopulations participating in clinical and prevention research has a significant impact on the representativeness of scientific outcomes and result in social and clinical injustices.(1) Latinos are one of the fastest growing population groups in the United States and in Western New York and mirror blacks in their perception of equally high levels of risk for participating in cancer screening examinations and for volunteering to become research participants in biomedical studies.(2) This proposal will investigate strategies to engage Latinos in Buffalo with scientists at Roswell Park Cancer Institute to increase mutual understanding of each other and participation in biospecimen donation for cancer prevention research, thereby, obtaining pilot data on variations in the types of biospecimens donated (i.e., saliva and/or blood). We will build on our existing partnership with a cohort of more than 500 Latina women and men who participated in a community-based breast and cervical cancer educational prevention inten/ention program (Study Title: Esperanza y Vida) to address the following specific aims: 1) Investigate the perceptions, knowledge and beliefs of representatives from the Latino community in Buffalo to determine how these perceptions are likely to impact participation in research using the Pata Bank & BioRepository (PBBR) as a focus, 2) Pevelop a pilot community-friendly intervention to enhance knowledge, understanding, intent, and participation in research by Latino residents that focuses on participation in the PBBR, 3) Investigate the feasibility and effectiveness of educating and recruiting Latina women and their families to biospecimen donation for research through community-based methods and interventions within the Esperanza y Vida study cohort as measured through attendance, surveys and study participation. Results from tiiis study are expected to identify specific barriers, challenges, and assets to research participation with our local Latino communities; and the technical accommodations necessary for a research institution and community partners to recruit, accrue, and analyze measures related to cancer research. This can lead to specific testable research hypotheses, potential for future environmental epidemiological CBPR studies, and provide guidelines and a foundation for building Latino community capacity around research projects.