Archiving the Vietnam Era Twin Studies of Aging (VETSA): New Uses for Old Data

归档越南时代双胞胎衰老研究 (VETSA)：旧数据的新用途

• 批准号: 8618060
• 负责人: CAROL Elaine FRANZ
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8618060
• 关键词: Adult; Affect; Age; Aging; Archives; Behavioral; Behavioral Genetics; Biological Markers; Blood Chemical Analysis; Brain; Code; Cognitive; Communities; Data; Data Collection; Data Set; Databases; Discipline; Documentation; Electronics; Episodic memory; Extensible Markup Language; Funding; Future; Generations; Genetic; Goals; Grant; Guidelines; Health; Health Policy; Hydrocortisone; Improve Access; International; Internet; Investments; Language; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Medical History; Memory; Metadata; National Institute on Aging; Neurosecretory Systems; Paper; Parents; Participant; Personality; Persons; Physical Function; Physiological; Procedures; Process; Programming Languages; Public Health; Public Policy; Records; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Sampling; Scanning; Science; Short-Term Memory; Social Sciences; Speed; Structure; System; Techniques; Testing; Testosterone; Time; Twin Multiple Birth; Twin Studies; Vietnam; Visuospatial; Work; aging brain; aging population; computerized; design; digital; electronic data; eligible participant; executive function; follow-up; improved; innovation; male; memory process; middle age; new technology; processing speed; programs; psychosocial; response; social; syntax; web site

DESCRIPTION (provided by applicant): The primary objective of this grant is to enhance and facilitate use of data from the Vietnam Era Twin Study of Aging (VETSA) for secondary analysis by archiving the data at the National Archive for Computerized Data on Aging (NACDA) at the Interuniversity Consortium for Political Science and Research (ICPSR). The VETSA is a nationwide longitudinal project designed to examine genetic and environmental influences on late midlife cognitive and brain changes. Starting in 2002, the baseline VETSA assessment conducted in-person testing of a community-dwelling sample of 1237 male twins ages 51-60 including a five- year follow-up completed in 2013. The project is unique in its inclusion of an in depth cognitive battery, magnetic resonance imaging data, neuroendocrine data, biomedical, biomarker, and psychosocial measures in the same middle-aged adults in the context of a behavior genetic study. We will achieve our primary objective as follows: Aim 1: We will apply new techniques associated with electronic documentation of social science data sets such as those developed by the Data Documentation Initiative (DDI-Lifecycle) to VETSA data. DDI- Lifecycle facilitates the creation of internet accessible social science data through the application of powerful programming languages such as electronic mark-up language (XML) in a format compliant with international archiving standards. Project-connected materials (e.g., procedures, codebooks, scoring systems, measures, variable definitions, statistical syntax, and datasets) will be documented and linked so as to facilitate interactive use by other researchers. Modern electronic archiving techniques expedite links within and between archived studies. Aim 2: Electronically documented VETSA materials will be placed at the NACDA/ICPSR archives where they can be easily accessed and disseminated through the internet. Aim 3: In addition to archiving data that are ready for analysis, we will create digital copies of actual on-paper responses of VETSA 2 participants (e.g., copies of drawn designs). By using up-to-date techniques for scanning and organizing documents in electronically searchable formats, these can be efficiently stored at the NACDA/ICPSR archives and easily retrieved by researchers. VETSA 1 on-paper records are already scanned and will be archived along with the VETSA 2 records. Access to original records and actual responses is immensely generative in that it allows future researchers to develop new techniques, approaches, and coding systems in ways never originally envisioned. The detailed electronic documentation proposed here is not part of the publicly available VETSA data, and the proposed project will provide the resources and infrastructure needed to implement the archiving. By making data structures easy to understand and easy to access, new generations of researchers can use the data for secondary analyses, thereby multiplying the National Institute on Aging's original investment in the VETSA. With our rapidly aging population, these data have potential for high public policy impact through the identification of risk and protective factors that may speed or delay cognitive and brain aging.

说明（由申请人提供）：这笔赠款的主要目的是通过将数据存档于大学间政治科学与研究联盟 (ICPSR) 的国家老龄化计算机化数据档案 (NACDA) 中，加强和促进越南时代双胞胎老龄化研究 (VETSA) 数据的使用，以进行二次分析。 VETSA 是一个全国性的纵向项目，旨在研究遗传和环境对中年晚期认知和大脑变化的影响。从 2002 年开始，基线 VETSA 评估对社区居住的 1237 名年龄在 51-60 岁的男性双胞胎样本进行了现场测试，其中包括 2013 年完成的五年随访。该项目的独特之处在于它纳入了一项 在行为遗传学研究的背景下，对同一中年人进行深度认知电池、磁共振成像数据、神经内分泌数据、生物医学、生物标志物和心理社会测量。我们将实现以下主要目标： 目标 1：我们将应用与社会科学数据集电子文档相关的新技术，例如数据文档计划 (DDI-Lifecycle) 开发的技术到 VETSA 数据。 DDI-Lifecycle 通过应用强大的编程语言（例如符合国际归档标准的格式的电子标记语言 (XML)），促进创建可通过互联网访问的社会科学数据。与项目相关的材料（例如程序、密码本、评分系统、测量、变量定义、统计语法和数据集）将被记录和链接，以促进其他研究人员的交互使用。现代电子归档技术加快了归档研究内部和之间的联系。目标 2：电子记录的 VETSA 材料将存放在 NACDA/ICPSR 档案馆中，以便可以通过互联网轻松访问和传播。目标 3：除了存档可供分析的数据外，我们还将创建 VETSA 2 参与者实际纸上回答的数字副本（例如绘制设计的副本）。通过使用最新技术以电子可搜索格式扫描和组织文档，这些文档可以有效地存储在 NACDA/ICPSR 档案中，并可由研究人员轻松检索。 VETSA 1 纸质记录已被扫描，并将与 VETSA 2 记录一起存档。获取原始记录和实际反应具有巨大的创造力，因为它允许未来的研究人员以最初从未设想过的方式开发新技术、方法和编码系统。这里提出的详细电子文档不属于公开可用的 VETSA 数据的一部分，拟议的项目将提供实施归档所需的资源和基础设施。通过使数据结构易于理解和访问，新一代研究人员可以使用这些数据进行二次分析，从而使国家老龄化研究所对 VETSA 的原始投资成倍增加。随着人口迅速老龄化，这些数据通过识别可能加速或延缓认知和大脑衰老的风险和保护因素，可能对公共政策产生重大影响。