Archiving the Vietnam Era Twin Studies of Aging (VETSA): New Uses for Old Data

归档越南时代双胞胎衰老研究 (VETSA)：旧数据的新用途

• 批准号: 8738573
• 负责人: CAROL Elaine FRANZ
• 金额: $ 11.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8738573
• 关键词: Adult; Affect; Age; Aging; Archives; Behavioral; Behavioral Genetics; Biological Markers; Blood Chemical Analysis; Brain; Code; Cognitive; Communities; Data; Data Collection; Data Set; Databases; Discipline; Documentation; Electronics; Episodic memory; Extensible Markup Language; Funding; Future; Generations; Genetic; Goals; Grant; Guidelines; Health; Health Policy; Hydrocortisone; Improve Access; International; Internet; Investments; Language; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Medical History; Memory; Metadata; National Institute on Aging; Neurosecretory Systems; Paper; Parents; Participant; Personality; Persons; Physical Function; Physiological; Procedures; Process; Programming Languages; Public Health; Public Policy; Records; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Sampling; Scanning; Science; Short-Term Memory; Social Sciences; Speed; Structure; System; Techniques; Testing; Testosterone; Time; Twin Multiple Birth; Twin Studies; Vietnam; Visuospatial; Work; aging brain; aging population; computerized; design; digital; electronic data; eligible participant; executive function; follow-up; improved; innovation; male; memory process; middle age; new technology; processing speed; programs; psychosocial; response; social; syntax; web site

DESCRIPTION (provided by applicant): The primary objective of this grant is to enhance and facilitate use of data from the Vietnam Era Twin Study of Aging (VETSA) for secondary analysis by archiving the data at the National Archive for Computerized Data on Aging (NACDA) at the Interuniversity Consortium for Political Science and Research (ICPSR). The VETSA is a nationwide longitudinal project designed to examine genetic and environmental influences on late midlife cognitive and brain changes. Starting in 2002, the baseline VETSA assessment conducted in-person testing of a community-dwelling sample of 1237 male twins ages 51-60 including a five- year follow-up completed in 2013. The project is unique in its inclusion of an in depth cognitive battery, magnetic resonance imaging data, neuroendocrine data, biomedical, biomarker, and psychosocial measures in the same middle-aged adults in the context of a behavior genetic study. We will achieve our primary objective as follows: Aim 1: We will apply new techniques associated with electronic documentation of social science data sets such as those developed by the Data Documentation Initiative (DDI-Lifecycle) to VETSA data. DDI- Lifecycle facilitates the creation of internet accessible social science data through the application of powerful programming languages such as electronic mark-up language (XML) in a format compliant with international archiving standards. Project-connected materials (e.g., procedures, codebooks, scoring systems, measures, variable definitions, statistical syntax, and datasets) will be documented and linked so as to facilitate interactive use by other researchers. Modern electronic archiving techniques expedite links within and between archived studies. Aim 2: Electronically documented VETSA materials will be placed at the NACDA/ICPSR archives where they can be easily accessed and disseminated through the internet. Aim 3: In addition to archiving data that are ready for analysis, we will create digital copies of actual on-paper responses of VETSA 2 participants (e.g., copies of drawn designs). By using up-to-date techniques for scanning and organizing documents in electronically searchable formats, these can be efficiently stored at the NACDA/ICPSR archives and easily retrieved by researchers. VETSA 1 on-paper records are already scanned and will be archived along with the VETSA 2 records. Access to original records and actual responses is immensely generative in that it allows future researchers to develop new techniques, approaches, and coding systems in ways never originally envisioned. The detailed electronic documentation proposed here is not part of the publicly available VETSA data, and the proposed project will provide the resources and infrastructure needed to implement the archiving. By making data structures easy to understand and easy to access, new generations of researchers can use the data for secondary analyses, thereby multiplying the National Institute on Aging's original investment in the VETSA. With our rapidly aging population, these data have potential for high public policy impact through the identification of risk and protective factors that may speed or delay cognitive and brain aging.

描述（由申请人提供）：这笔赠款的主要目的是通过在国家国际衰老计算机化数据（NACDA）的数据档案中归档政治科学与研究（ICPSR）的国际化联盟中的国家计算机数据（NACDA）的数据来增强和促进越南时代的衰老研究（VETSA）进行二次分析的数据。 VETSA是一个全国范围内的纵向项目，旨在检查对中年后期认知和大脑变化的遗传和环境影响。从2002年开始，基线VETSA评估对1237个男性双胞胎51-60岁的男性双胞胎进行了面对面测试，其中包括2013年完成的五年随访。该项目在其中包括AN的独特之处。 在行为遗传研究的背景下，深度认知电池，磁共振成像数据，神经内分泌数据，生物医学，生物标志物和社会心理测量。我们将实现我们的主要目标：AIM 1：我们将应用与社会科学数据集的电子文档相关的新技术，例如由数据文档计划（DDI-Lifecycle）开发的技术来VETSA数据。 Ddddi-lifecycle通过应用强大的编程语言（例如电子标记语言（XML））以符合国际归档标准的格式来促进互联网访问的社会科学数据。将记录和链接项目连接的材料（例如，程序，代码书，评分系统，措施，可变定义，统计语法和数据集），以促进其他研究人员的交互式使用。现代电子档案技术在存档研究之间和之间加快了链接。 AIM 2：电子记录的VETSA材料将放置在NACDA/ICPSR档案馆，在那里可以轻松地通过互联网访问和传播它们。 AIM 3：除了归档准备分析的数据外，我们还将创建Vetsa 2参与者的实际上纸响应的数字副本（例如，绘制设计的副本）。通过使用最新的技术以电子搜索格式扫描和组织文档，可以有效地存储在NACDA/ICPSR档案中，并很容易由研究人员检索。 VETSA 1纸上记录已经扫描，将与Vetsa 2记录一起存档。访问原始记录和实际响应是非常生成的，因为它允许未来的研究人员以最初从未设想的方式开发新技术，方法和编码系统。这里提出的详细电子文档不是公开可用的VETSA数据的一部分，拟议的项目将提供实施归档所需的资源和基础架构。通过使数据结构易于理解且易于访问，新一代的研究人员可以使用数据进行次要分析，从而将国家研究所在老化对Vetsa的原始投资上增加。随着我们迅速衰老的人口，这些数据具有通过识别可能加快或延迟认知和大脑衰老的风险和保护因素来产生高公共政策影响的潜力。