Optimizing Couple-Oriented Interventions for Chronic Illness

描述（由申请人提供）：大多数患有慢性疾病的成年人都是已婚或有亲密关系的，然而绝大多数的行为干预都不能解决这种关系的影响或疾病对伴侣的影响。因此，这种干预措施不太可能对许多患者完全有效，甚至可能适得其反。本次K02独立科学家奖（ISA）授予Lynn Martire博士的目的是推动以夫妻为导向的慢性病干预措施（CIs）的发展，使患者和配偶都受益，并为婚姻和健康模式提供信息。该奖项的重点将放在美国所有健康问题中最致命和最昂贵的三种慢性病：心血管疾病、癌症和糖尿病。Martire博士的职业发展活动将解决设计、测量和分析问题，这些问题对未来CI研究的成功至关重要。该机构的研究活动将为有关婚姻和健康的文献增添重要信息，并通过关注家庭环境中发生的短期过程如何影响健康，为下一代儿童提供信息。目的#1和2将使用膝关节骨关节炎和2型糖尿病研究中收集的双元日记数据，研究患有慢性疾病的夫妇的日常过程，以及调节这些过程的个体和夫妻水平特征。第三个目标是收集夫妻在家中健康互动的试点观察数据。目标4将把这些项目和其他项目的发现应用于针对夫妇的适应性跨疾病干预措施的开发。由于她在晚年慢性疾病，家庭护理以及干预对患者和护理者的影响方面的研究专长，该候选人在该领域具有独特的重大进展。研究和培训活动将由一组顾问提供便利，他们是亲密关系、健康、纵向测量和分析、干预发展和生态短暂干预等领域的主要专家。此外，候选人还组建了一个由既定研究人员组成的国家工作组，针对本ISA的三个重点条件测试CIs。

DESCRIPTION (provided by applicant): Most adults who suffer from a chronic illness are married or in an intimate relationship, yet the vast majority of behavioral interventions fail to address this relationship's impact or the effects of illness on the partner. Therefore, such interventions are not likely to be fully effective for many patients, and may even backfire. The purpose of this proposed K02 Independent Scientist Award (ISA) to Dr. Lynn Martire is to advance the development of couple-oriented interventions (CIs) for chronic illness that benefit both patients and spouses and also inform models of marriage and health. The focus of this award will be three chronic conditions that are the most deadly and costly of all health problems in the United States: cardiovascular disease, cancer, and diabetes. Dr. Martire's career development activities will address design, measurement, and analysis issues that are critical for the success of future CI research. The research activities of this ISA will add critical information to the literature on marriage and health, and inform the next generation of CIs, by focusing on how short-term processes that occur in the home environment affect health. Aims #1 and 2 will examine daily processes in couples living with chronic illness, as well as individual and couple-level characteristics that moderate these processes, using dyadic diary data collected in studies of knee osteoarthritis and Type 2 diabetes. Aim #3 is to collect pilot observational data on couples' health-related interactions in the home. Aim #4 will apply findings from these and other projects to the development of an adaptive, cross-disease intervention for couples. The Candidate is uniquely poised to make significant advances in this area due to her research expertise in late-life chronic illness, family caregiving, and the effects of intervention on both patient and caregiver. Research and training activities will be facilitated by a team of Consultants who are leading experts in the areas of intimate relationships, health, longitudinal measurement and analysis, intervention development, and ecological momentary intervention. In addition, the Candidate has assembled a National Working Group of established researchers testing CIs for the three focal conditions of this ISA.