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Robotic Crawler for Epicardial Interventions

用于心外膜介入治疗的机器人爬行器

基本信息

批准号：
8469549
负责人：
Cameron N Riviere
金额：
$ 35.17万
依托单位：
CARNEGIE-MELLON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8469549
关键词：
4D Imaging Anesthesia procedures Area Artificial Heart Cardiac Chest wall structure Clinical Data Data Set Diagnosis Diagnostic Electrocardiogram Electrodes Environmental air flow Epicardium Evaluation Family suidae Goals Grant Hand Health Heart Heart failure Image Imagery Imaging Techniques In Vitro Infarction Injection of therapeutic agent Ink Intervention Investigation Joystick Location Locomotion Lung Magnetism Maps Medicine Methods Modeling Motor Outcome Pericardial body location Physiology Pleural Positioning Attribute Procedures Process Public Health Reading Research Robotics Running Simulate Specialist Suction Surface Surgeon Surgical incisions System Techniques Technology Testing Tissues Training Vision clinical application design electric impedance endotracheal epicardial mapping heart imaging imaging modality improved in vivo in vivo Model innovation minimally invasive pericardial sac prototype technology development tissue phantom tool

项目摘要

DESCRIPTION (provided by applicant): In the last few years our group has pioneered an innovative minimally invasive approach to the heart for a growing portfolio of therapies that appeals to both minimally invasive cardiac surgeons and interventional specialists (e.g., cardiac electrophysiologists). The approach involves direct subxiphoid access to the pericardial space without interfering with the chest wall integrity and physiology. The clinical procedures that could benefit from such an approach include many that are performed wholly or primarily within the intrapericardial space. To date, many such procedures are performed thoracoscopically, necessitating differential lung ventilation and general endotracheal anesthesia. During the original period of this R01 grant, we have demonstrated the feasibility of intrapericardial intervention on the beating heart without entering the pleural space by developing "HeartLander", a tethered miniature robotic crawler that enters the pericardium via subxiphoid incision, attaches itself directly to the surface of the beating heart, moves to the desired epicardial location, and delivers therapy under the control of the surgeon. A prominent clinical goal in recent years in cardiac medicine has been the concept of combining diagnosis and treatment in a single session, sometimes referred to as "one-stop shopping." HeartLander is well suited as a delivery vehicle for both diagnostic and interventional tools of various types, and as such is an ideal tool for realizing this vision. Potential clinical applications are numerous; as an example application, we propose to focus the development of the technology on its relevance to heart failure. We hypothesize that HeartLander can autonomously map an infarct region epicardially and intervene (delineating the region with injected ink) more accurately and more rapidly than a trained clinician using state-of-the-art hand-guided tools. This research aims to develop methods for image-guided autonomous locomotion of HeartLander, first using static heart image data, and then using dynamic (beating) heart imagery. Techniques for image-guided autonomous epicardial mapping will be developed. Finally, methods will be developed for simultaneous image-guided autonomous cardiac mapping and intervention in a single session. All techniques developed will be evaluated, first in appropriate artificial heart phantoms, and then in a porcine model in vivo.

描述（由申请人提供）：在过去的几年里，我们的团队开创了一种创新的心脏微创方法，用于不断增长的治疗组合，吸引了微创心脏外科医生和介入专家（例如，心脏电生理学家）。该入路涉及直接剑突下进入心包腔，而不会干扰胸壁完整性和生理学。可以从这种方法中受益的临床手术包括许多完全或主要在心包腔内进行的手术。迄今为止，许多这样的手术是在胸腔镜下进行的，需要差异肺通气和全身气管内麻醉。在R 01资助的最初阶段，我们通过开发“HeartLander”证明了在不进入胸膜腔的情况下对跳动的心脏进行心包内介入的可行性，HeartLander是一种拴系的微型机器人爬行器，通过剑突下切口进入心包，直接附着在跳动的心脏表面，移动到所需的心外膜位置，并在外科医生的控制下提供治疗。近年来，心脏病医学的一个突出的临床目标是将诊断和治疗结合在一个疗程中，有时被称为“一站式购物”。“HeartLander非常适合作为各种类型的诊断和介入工具的运载工具，因此是实现这一愿景的理想工具。潜在的临床应用有很多;作为一个应用实例，我们建议将该技术的开发重点放在其与心力衰竭的相关性上。我们假设HeartLander可以自主地标测心外膜梗死区域，并比训练有素的临床医生使用最先进的手动引导工具更准确、更快速地进行干预（用注射墨水描绘该区域）。本研究旨在开发HeartLander图像引导自主运动的方法，首先使用静态心脏图像数据，然后使用动态（跳动）心脏图像。将开发图像引导的自主心外膜标测技术。最后，将开发用于在单个会话中同时进行图像引导的自主心脏标测和干预的方法。将首先在适当的人工心脏体模中，然后在猪体内模型中对开发的所有技术进行评价。

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation in vitro of a treatment planning algorithm for an epicardial crawling robot.

心外膜爬行机器人治疗计划算法的体外评估。

DOI：
10.1109/iembs.2010.5627690
发表时间：
2010
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
0
作者：
Goyette,BrinaE;Becker,BrianC;Zenati,MarcoA;Riviere,CameronN
通讯作者：
Riviere,CameronN

Auto-Calibration for a Planar Epicardial Wire Robot.

平面心外膜线机器人的自动校准。

DOI：
10.1109/nebec.2015.7117150
发表时间：
2015
期刊：
Proceedings of the IEEE ... annual Northeast Bioengineering Conference. IEEE Northeast Bioengineering Conference
影响因子：
0
作者：
Breault,MacauleyS;Costanza,AdamD;Wood,NathanA;Passineau,MichaelJ;Riviere,CameronN
通讯作者：
Riviere,CameronN

Synchronization of epicardial crawling robot with heartbeat and respiration for improved safety and efficiency of locomotion.

心外膜爬行机器人与心跳和呼吸同步，以提高运动的安全性和效率。

DOI：
10.1002/rcs.442
发表时间：
2012
期刊：
The international journal of medical robotics + computer assisted surgery : MRCAS
影响因子：
0
作者：
Patronik,NicholasA;Ota,Takeyoshi;Zenati,MarcoA;Riviere,CameronN
通讯作者：
Riviere,CameronN

Towards localizing on the surface of the beating heart.

定位于跳动的心脏表面。