Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
基本信息
- 批准号:8389884
- 负责人:
- 金额:$ 35.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-07-01 至 2014-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse effectsAgeAmericasAngiotensin IIAngiotensinogenApoptosisArrhythmiaAutomobile DrivingBindingBinding ProteinsBloodBlood CirculationBrainBrain regionCardiacCardiovascular systemCerebrospinal FluidChronicClinicalClinical ResearchClinical TrialsCritiquesDataDinoprostoneDiseaseDoseEnzymesEtanerceptEtiologyEuropeExclusionFamilyGoalsHealedHealthHeartHeart failureHospitalizationHumanHypothalamic structureImmune systemIndustryInfectionInflammationInflammation MediatorsInflammatoryInflammatory ResponseInjuryInterventionInvestigationIschemiaKidneyLeft Ventricular FunctionLifeLiteratureLymphomaMediatingMediator of activation proteinMethodsModelingMolecularMorbidity - disease rateMyocardial dysfunctionNADPNF-kappa BNerveNeuraxisNeuronsNuclearOxidasesPatientsPericytesPeripheralPlasmaPopulationPreventive InterventionProcessProductionProsencephalonProstaglandinsProtein PrecursorsProteinsPublishingRattusReactive Oxygen SpeciesReceptor, Angiotensin, Type 1RegimenReninRenin-Angiotensin SystemResearchRoleSeverity of illnessSourceStimulusSuperoxidesSympathetic Nervous SystemSyndromeTNF geneTestingTherapeuticTherapeutic InterventionTissuesTumor Necrosis Factor-alphaUnited StatesWorkabstractingadverse outcomebrain tissuecyclooxygenase 2cytokinehealinghuman old age (65+)infliximabinsightmembermortalityneurochemistryneuromechanismnovelnovel strategiesparaventricular nucleusreceptorstatisticstranscription factorvasoconstriction
项目摘要
6. Project Summary/Abstract
Heart failure is the most common reason for hospitalization in the United States among those older than 65
years, and this statistic is expected to grow as the population ages. Overactivity of the sympathetic nervous
system is a cardinal manifestation of the heart failure syndrome, and a strong predictor of morbidity and
mortality. The etiology of increased sympathetic activity in heart failure is multifactorial. Recent studies have
implicated inflammatory mechanisms that generate reactive oxygen species, particularly activation of
nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase dependent superoxide, in cardiovascular
regions of the brain. The ability of angiotensin II to generate superoxide and sympathetic drive by this
mechanism has been well studied - almost to the exclusion of other inflammatory mediators that are also
increased in heart failure and might well contribute. The present project examines the potential role of the pro-
inflammatory cytokines, which increase in plasma and brain of rats with ischemia-induced heart failure, are
capable of NAD(P)H oxidase driven superoxide production, and are known to contribute to increased
sympathetic drive in heart failure. We will test three hypotheses with regard to the mechanisms by which pro-
inflammatory cytokines might activate the sympathetic nervous system in a rat model of ischemia-induced
heart failure that mimics the most common form of heart failure in humans: 1) pro-inflammatory cytokines
increase sympathetic nerve activity in heart failure rats by inducing cyclooxygenase-2 activity and the
production of prostaglandin E2, which is sympatho-excitatory in the brain; 2) pro-inflammatory cytokines
increase sympathetic nerve activity in heart failure rats by upregulating the brain renin-angiotensin system and
the production of angiotensin II, which is sympatho-excitatory in the brain in its own right as well as by
stimulating superoxide production; and 3) pro-inflammatory cytokines directly stimulate NAD(P)H oxidase
dependent superoxide production. This project focuses upon the actions of pro-inflammatory cytokines in the
paraventricular nucleus of the hypothalamus, a forebrain cardiovascular regulatory center that has been
identified as an important source of the increased sympathetic nerve activity in heart failure. Neurochemical
changes in the paraventricular nucleus in heart failure, and the cellular and molecular mechanisms which
regulate them, will be investigated using molecular and immunohistochemical/immunofluorescent methods,
and the results of those studies will be correlated with functional data from electrophysiological studies
examining the effects of manipulating key putative mediators of sympathetic nerve activity. These studies will
identify currently unrecognized mechanisms driving the sympathetic nervous system in heart failure, and thus
potential targets for preventive intervention.
6.项目总结/摘要
心力衰竭是美国65岁以上老年人住院治疗的最常见原因
这一统计数据预计将随着人口老龄化而增长。交感神经过度活跃
系统是心力衰竭综合征的主要表现,并且是发病率和
mortality.心力衰竭时交感神经活动增加的病因是多因素的。最近的研究
涉及产生活性氧的炎症机制,特别是激活
烟酰胺腺嘌呤二核苷酸磷酸[NAD(P)H]氧化酶依赖性超氧化物,心血管
大脑的各个区域。血管紧张素II产生超氧化物和交感神经驱动的能力,
机制已经得到了很好的研究-几乎排除了其他炎症介质,
心力衰竭的发病率增加,这可能是原因之一。本项目审查了亲的潜在作用,
缺血性心力衰竭大鼠血浆和脑中增加的炎性细胞因子,
能够NAD(P)H氧化酶驱动的超氧化物产生,并且已知有助于增加
交感神经冲动在心力衰竭中的作用我们将测试三个假设的机制,通过亲,
炎症细胞因子可能激活缺血诱导的大鼠模型的交感神经系统,
类似于人类最常见的心力衰竭形式的心力衰竭:1)促炎细胞因子
通过诱导环氧合酶-2活性增加心力衰竭大鼠的交感神经活性,
前列腺素E2的产生,其在脑中是交感神经兴奋的; 2)促炎细胞因子
通过上调脑肾素-血管紧张素系统增加心力衰竭大鼠的交感神经活性,
血管紧张素II的产生,其本身在大脑中具有交感神经兴奋性,
刺激超氧化物产生;和3)促炎细胞因子直接刺激NAD(P)H氧化酶
依赖性超氧化物生成。该项目的重点是促炎细胞因子在炎症反应中的作用。
下丘脑的室旁核,一个前脑心血管调节中心,
被认为是心力衰竭时交感神经活动增加的重要来源。神经化学
心力衰竭时室旁核的变化,以及
调节它们,将使用分子和免疫组织化学/免疫荧光方法进行研究,
这些研究的结果将与电生理学研究的功能数据相关联
检查操纵交感神经活动的关键假定介质的影响。这些研究将
确定目前尚未认识到的机制,在心力衰竭中驱动交感神经系统,从而
预防性干预的潜在目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert B Felder其他文献
Robert B Felder的其他文献
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{{ truncateString('Robert B Felder', 18)}}的其他基金
Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
- 批准号:
8399052 - 财政年份:2010
- 资助金额:
$ 35.34万 - 项目类别:
Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
- 批准号:
8204899 - 财政年份:2010
- 资助金额:
$ 35.34万 - 项目类别:
Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
- 批准号:
8038587 - 财政年份:2010
- 资助金额:
$ 35.34万 - 项目类别:
Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
脑 MAP 激酶 - 心力衰竭交感神经兴奋的底物
- 批准号:
8589602 - 财政年份:2010
- 资助金额:
$ 35.34万 - 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
- 批准号:
8758110 - 财政年份:2003
- 资助金额:
$ 35.34万 - 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
- 批准号:
6671631 - 财政年份:2003
- 资助金额:
$ 35.34万 - 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
- 批准号:
8197258 - 财政年份:2003
- 资助金额:
$ 35.34万 - 项目类别:
Cytokine and sympathetic drive in heart failure
心力衰竭中的细胞因子和交感神经驱动
- 批准号:
6704843 - 财政年份:2003
- 资助金额:
$ 35.34万 - 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
- 批准号:
7751935 - 财政年份:2003
- 资助金额:
$ 35.34万 - 项目类别:
Cytokines and Sympathetic Activation in Heart Failure
心力衰竭中的细胞因子和交感神经激活
- 批准号:
7078626 - 财政年份:2003
- 资助金额:
$ 35.34万 - 项目类别:
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