Increased airway smooth muscle mass as an independent determinant of asthma pathogenesis and severity

气道平滑肌质量增加是哮喘发病机制和严重程度的独立决定因素

• 批准号: nhmrc : 1027218
• 负责人: A/Pr Alexander Larcombe
• 金额: $ 27.34万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/increased-airway-smooth-pathogenesis-severity/110549
• 关键词: Increased; airway; smooth; muscle; mass

Asthma is a major health burden to the community. The most common form of the disease is allergic asthma and it is thought that allergic inflammation drives associated airway abnormalities including increased airway smooth muscle (ASM) mass. This study tests a new hypothesis that airway abnormalities and allergy have separate origins but combine to produce allergic asthma, and it’s the individuals with the greatest amount of ASM who develop clinically severe asthma.

哮喘是社区的主要健康负担。这种疾病最常见的形式是过敏性哮喘，人们认为过敏性炎症会导致相关的呼吸道异常，包括气道平滑肌(ASM)质量增加。这项研究检验了一种新的假设，即呼吸道异常和过敏有不同的起源，但联合起来会产生过敏性哮喘，而且ASM数量最多的人会患上临床上严重的哮喘。