Airway epithelial barrier function, asthma and aero-allergen sensitization.

气道上皮屏障功能、哮喘和空气过敏原致敏。

• 批准号: nhmrc : 1026494
• 负责人: A/Pr Alexander Larcombe
• 金额: $ 35.2万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/airway-epithelial-barrier-allergen-sensitization/110499
• 关键词: Airway; epithelial; barrier; function; asthma

There is a strong association between allergy and asthma. This association been almost universally assumed to be causative. However, recent evidence suggests an alternative explanation ie., that the abnormal epithelium in asthma allows or facilitates sensitization to airborne allergens. This project will test this alternative hypothesis using human lung tissue and an animal model.

过敏和哮喘之间有很强的联系。这种联系几乎被普遍认为是因果关系。然而，最近的证据提出了另一种解释，即，哮喘中的异常上皮允许或促进对空气过敏原的致敏。本项目将使用人类肺组织和动物模型来检验这一备择假设。