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Eosinophil trafficking and chronic tissue damage induced by allergic inflammation

Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
过敏性炎症引起的嗜酸性粒细胞运输和慢性组织损伤
批准号:
8389838
负责人:
DAVID H BROIDE
金额:
$37.82万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-04-01 至 2016-11-30

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中文摘要
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英文摘要
C. ABSTRACT OF PLANNED BODY OF WORK We plan to continue our studies of angiogenesis and remodeling in eosinophil associated diseases. Areas of innovation: The studies investigate novel pathways that are unexplored in mediating allergen induced remodeling (including Del-1 interacting with VEGF; MMP-7; trafficking of endothelial and fibroblast progenitors), use novel reagents (endothelial cell specific knockout of Del-1; Tie GFP and Col-1 GFP transgenic mice to track endothelial and fibroblast progenitors), and discovery approaches (proteomics, microarray) to identify differentially expressed genes/proteins in chronic vs acute allergen challenged lung (identified several candidates including Wnt signaling member Kremin; miRNA376b). In addition the availability of specimens from asthma and EE allow the findings to be translated to human subjects with remodeling.
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Targeting lipid rafts for treatment of asthma
  • 批准号:
    10697410
  • 项目类别:
  • 资助金额:
    $100.0万
  • 财政年份:
    2019
  • 负责人:
    DAVID H BROIDE
  • 依托单位:
IOF Management Core
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