Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
Eosinophil trafficking and chronic tissue damage induced by allergic inflammation
批准号:
8389838
负责人:
DAVID H BROIDE
金额:
$37.82万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-04-01 至 2016-11-30
关键词:
AcuteAdhesionsAllergensAllergic inflammationApplications GrantsAreaAsthmaBone MarrowBreathingChronicDiseaseEndothelial CellsFibroblastsFibrosisGene ProteinsInflammatoryKnock-outLungMatrilysinMediatingPathway interactionsPermeabilityPropertyProtein IsoformsProteomicsReagentSignal TransductionSpecimenTissuesTransgenic MiceTranslatingVascular Endothelial Growth Factorsabstractingangiogenesischromosome 1 losseosinophilhuman subjectinnovationmembernovelprogenitortrafficking
中文摘要
点击翻译按钮获取中文摘要
英文摘要
C. ABSTRACT OF PLANNED BODY OF WORK
We plan to continue our studies of angiogenesis and remodeling in eosinophil associated diseases.
Areas of innovation: The studies investigate novel pathways that are unexplored in mediating allergen
induced remodeling (including Del-1 interacting with VEGF; MMP-7; trafficking of endothelial and fibroblast
progenitors), use novel reagents (endothelial cell specific knockout of Del-1; Tie GFP and Col-1 GFP
transgenic mice to track endothelial and fibroblast progenitors), and discovery approaches (proteomics,
microarray) to identify differentially expressed genes/proteins in chronic vs acute allergen challenged lung
(identified several candidates including Wnt signaling member Kremin; miRNA376b). In addition the availability
of specimens from asthma and EE allow the findings to be translated to human subjects with remodeling.
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会议论文
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批准号:10697410
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资助金额:$100.0万
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依托单位:
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批准号:9542177
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资助金额:$48.53万
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财政年份:2016
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依托单位:
Chromosome 17q, allergic inflammation, and remodeling
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资助金额:$36.43万
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财政年份:2013
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依托单位:
Chromosome 17q, allergic inflammation, and remodeling
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批准号:9262840
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项目类别:
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资助金额:$38.75万
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财政年份:2013
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负责人:DAVID H BROIDE
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依托单位:
Chromosome 17q21, allergic inflammation, and remodeling
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批准号:10581533
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项目类别:
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资助金额:$56.14万
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财政年份:2013
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负责人:DAVID H BROIDE
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依托单位:
Chromosome 17q, allergic inflammation, and remodeling
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批准号:8661705
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资助金额:$38.75万
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财政年份:2013
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负责人:DAVID H BROIDE
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依托单位:
Chromosome 17q, allergic inflammation, and remodeling
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批准号:8836486
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项目类别:
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资助金额:$38.75万
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财政年份:2013
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负责人:DAVID H BROIDE
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依托单位:
Chromosome 17q21, allergic inflammation, and remodeling
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批准号:9885992
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项目类别:
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资助金额:$58.25万
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财政年份:2013
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负责人:DAVID H BROIDE
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依托单位:
Chromosome 17q21, allergic inflammation, and remodeling
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批准号:10348767
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项目类别:
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资助金额:$56.41万
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财政年份:2013
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负责人:DAVID H BROIDE
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依托单位:
THE IDENTIFICATION OF POTENTIALLY EPITOPES FROM COMMON HUMAN ALLERGANS
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批准号:8166854
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项目类别:
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资助金额:$1.92万
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财政年份:2009
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负责人:DAVID H BROIDE
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依托单位:
THE IDENTIFICATION OF POTENTIALLY EPITOPES FROM COMMON HUMAN ALLERGANS
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批准号:7951005
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项目类别:
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资助金额:$3.4万
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财政年份:2008
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负责人:DAVID H BROIDE
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依托单位:
Siglec-F and Resolution of Allergic Inflammation
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批准号:7372557
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项目类别:
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资助金额:$34.76万
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财政年份:2007
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负责人:DAVID H BROIDE
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依托单位:
Siglec-F and Resolution of Allergic Inflammation
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批准号:7995200
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项目类别:
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资助金额:$34.07万
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财政年份:2007
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负责人:DAVID H BROIDE
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依托单位:
Siglec-F and Resolution of Allergic Inflammation
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批准号:8196906
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项目类别:
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资助金额:$34.07万
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财政年份:2007
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负责人:DAVID H BROIDE
-
依托单位:
Siglec-F and Resolution of Allergic Inflammation
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批准号:7538345
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项目类别:
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资助金额:$34.76万
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财政年份:2007
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负责人:DAVID H BROIDE
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依托单位:
Siglec-F and Resolution of Allergic Inflammation
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批准号:7728267
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项目类别:
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资助金额:$34.41万
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财政年份:2007
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负责人:DAVID H BROIDE
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依托单位:
Airway inflammation and airway remodeling
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批准号:8164373
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项目类别:
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资助金额:$157.98万
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财政年份:2006
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负责人:DAVID H BROIDE
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依托单位:
Airway Inflammation and Airway Remodeling
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批准号:7490387
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项目类别:
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资助金额:$142.99万
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财政年份:2006
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负责人:DAVID H BROIDE
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依托单位:
Airway inflammation and airway remodeling
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批准号:8516963
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项目类别:
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资助金额:$135.69万
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财政年份:2006
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负责人:DAVID H BROIDE
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依托单位:
海外基金