Clinical Research and Retrovirology (CRRC)

临床研究和逆转录病毒学（CRRC）

• 批准号: 8520674
• 负责人: Robert D. Harrington
• 金额: $ 37.05万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8520674
• 关键词: AIDS/HIV problem; Address; Biological; Biological Assay; Characteristics; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Collaborations; Computational Biology; Data; Data Collection; Development; Disease; Disease Progression; Enrollment; Epidemiology; Goals; HIV; Human; Immunology; Individual; Instruction; International; Investigation; Laboratories; Link; Mission; Participant; Pathogenesis; Patients; Persons; Phenotype; Procedures; Recruitment Activity; Registries; Research; Research Personnel; Research Project Grants; Research Subjects; Resources; Retrovirology; Sampling; Scientist; Services; Specimen; Study Subject; Testing; Tissue Sample; Translational Research; Universities; Washington; clinical epidemiology; follow-up; forging; innovation; interest; meetings; novel; prevent; prospective; repository; research study; sample collection; tool; transmission process

PROJECT SUMMARY (See instructions): A critical challenge to understanding, preventing and treating HIV and HIV-related diseases is the need for human clinical specimens and data from individuals with specific clinical and epidemiologic characteristics, and access to new, innovative laboratory tools needed to analyze biological specimens. The mission of the Clinical and Retrovirology Research Core (CRRC), a fusion of the Clinical Research and Retrovirology Cores, is to support access by local, regional and international investigators to clinical specimens, data and the assays they need to conduct clinical and translational HIV research projects. To accomplish this, the CRRC has developed specific resources to link participants recruited through the major UW-associated HIV clinics in Seattle (or samples and data from them) to individual HIV investigators. The CRRC will accomplish its mission in five ways: First, for investigators seeking eligible research subjects to enroll in specific studies, the CRRC will continue the highly successful Research Referral Service. Second, for translational investigators seeking human specimens, the CRRC will use two approaches with complementary strengths: 1) a more limited version of the existing HIV Specimen Repository with prospective follow-up and routine specimen and data collection, and 2) an enhanced version of the existing Special Specimen Collection Service with specific project-directed collection of specimens and data. Third, to address the need for control specimens from HIV-negative persons, the CRRC will establish a new registry of HIV negative patients interested in participating in HIV research studies. Fourth, to support laboratory analyses for specific HIV studies, the CRRC will provide basic testing and develop specialized laboratory assays required for specific HIV studies. Finally, to accelerate the pace of planned studies and stimulate new directions of research, the CRRC will create and strengthen linkages with other UW CFAR cores and other CFARs (CNICS). Specifically, the CRRC will coordinate regular meetings with the immunology, clinical epidemiology and computational biology cores to scrutinize and integrate requests for services made to any of the cores and maximize efficient and novel uses of samples and laboratory testing capacity.

项目总结(见说明)： 了解、预防和治疗艾滋病毒和艾滋病毒相关疾病的一个关键挑战是需要人类临床标本和具有特定临床和流行病学特征的个人的数据，并需要获得分析生物标本所需的新的创新实验室工具。临床和逆转录病毒学研究核心(CRRC)是临床研究和逆转录病毒学核心的融合，其使命是支持当地、地区和国际研究人员获取临床标本、数据和他们进行临床和翻译艾滋病毒研究项目所需的分析。为了实现这一目标，CRRC开发了具体的资源，将通过西雅图与威斯康星州大学相关的主要艾滋病毒诊所招募的参与者(或从他们那里获得的样本和数据)与个别艾滋病毒调查人员联系起来。中国中车将通过五种方式完成其使命：第一，对于寻求符合条件的研究对象注册特定研究的研究人员，中国中车将继续提供非常成功的研究转诊服务。第二，对于寻找人类标本的翻译研究人员，中国研究中心将使用两种优势互补的方法：1)对现有的艾滋病毒标本储存库进行更有限的版本，并进行预期的跟进和常规标本和数据收集；以及2)对现有的特别标本收集服务进行增强版本，以特定项目为导向收集标本和数据。第三，为了满足对艾滋病毒阴性者对照样本的需求，中国研究中心将建立一个新的艾滋病毒阴性患者登记册，登记有兴趣参与艾滋病毒研究的患者。第四，为了支持特定艾滋病毒研究的实验室分析，中国研究中心将提供基本测试，并开发特定艾滋病毒研究所需的专门实验室分析。最后，为了加快规划研究的步伐，并鼓励新的研究方向，中国中车将建立和加强与UW CFAR其他核心和其他CFAR(CNIC)的联系。具体地说，中国中车将与免疫学、临床流行病学和计算生物学核心协调定期会议，以审查和整合向任何核心提出的服务请求，并最大限度地高效和创新地使用样本和实验室检测能力。