Center for Research on the Ethical, Legal and Social Implications of Psychiatric

精神病学的伦理、法律和社会影响研究中心

• 批准号: 8514197
• 负责人: Paul Stuart Appelbaum
• 金额: $ 115.55万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514197
• 关键词: Academic Medical Centers; Address; Area; Behavior; Behavior Disorders; Behavioral Genetics; Characteristics; Complex; Data; Development; Ensure; Environment; Ethics; Eye; Faculty; Fostering; Foundations; Funding; Future; Genetic; Genetic Predisposition to Disease; Goals; Grant; Growth; Individual; Learning; Mental disorders; Mentors; Nature; Neurodegenerative Disorders; Neurodevelopmental Disorder; Neurologic; Neurology; Output; Perception; Personal Satisfaction; Policies; Psychiatry; Public Health; Recommendation; Research; Research Infrastructure; Research Training; Resources; Self Perception; Signal Transduction; Social Impacts; Structure; Sum; Time; Training; Training Activity; Training Programs; Translating; Translations; Universities; Variant; base; career; ethical legal social implication; experience; improved; innovation; interdisciplinary collaboration; legal implication; multidisciplinary; policy implication; post-doctoral training; prenatal; programs; public health relevance; response; screening; skills; social implication; social stigma; success; teacher; technique development; trait

DESCRIPTION (provided by applicant): This application proposes the establishment of a Center for Research on the Ethical, Legal and Social Implications of Psychiatric, Neurologic and Behavioral (PNB) Genetics at Columbia University Medical Center (CUMC). Since April 2010, we have been funded under a P20 Developing Center grant to create the infrastructure and begin development of such a Center. PNB genetics present particular ethical, legal and social challenges because of the highly stigmatized nature of many PNB disorders and traits; the potential impact of genetic predispositions for PNB disorders and traits on perceptions of responsibility for behavior; and the complex interactions between genetic propensities and environmental influences that determine the onset and course of many PNB disorders, rendering the implications of many PNB genetic data inherently ambiguous. Our new Center will promote thoughtful consideration of the range of issues arising in the context of PNB genetics and develop innovative approaches to addressing them. Specifically, we will undertake a focused program of research that explores the impact of PNB genetic information at the individual, familiar and societal levels, considering its effects on stigma and self-image, attributions of responsibility, and responses to ambiguity, along with systematic consideration of the broader normative and policy implications of our findings. To maximize the value of our research, we will create robust mechanisms to translate the empirical and normative output of our research into recommendations for policy and practice, capitalizing on the involvement of other experts and key stakeholder groups. With an eye on the future of ELSI studies, we will develop a multidisciplinary post-doctoral training program focused on nurturing future leaders in ELSI research, creating an environment that facilitates cross-disciplinary learning and research and draws on outstanding mentors and teachers. In sum, we will create a structure that builds on our existing strengths and accomplishments to enhance transdisciplinary collaboration, facilitate the conduct of innovative research, and foster intellectual growth among both faculty and trainees.

描述（由申请人提供）：本申请建议在哥伦比亚大学医学中心（CDC）建立精神病学、神经病学和行为学（PNB）遗传学的伦理、法律的和社会影响研究中心。自2010年4月以来，我们得到了P20发展中心赠款的资助，以创建基础设施并开始发展这样一个中心。PNB遗传学提出了特殊的伦理，法律的和社会的挑战，因为许多PNB疾病和特征的高度污名化的性质; PNB疾病和特征的遗传倾向对行为责任感的潜在影响;以及遗传倾向和环境影响之间复杂的相互作用，决定了许多PNB疾病的发病和病程，这使得许多PNB遗传数据的含义本质上是模糊的。我们的新中心将促进对PNB遗传学背景下出现的一系列问题的深思熟虑，并开发创新方法来解决这些问题。具体来说，我们将进行一项重点研究计划，探索PNB遗传信息在个人，熟悉和社会层面的影响，考虑其对耻辱和自我形象，责任归属和对模糊性的反应的影响，沿着我们的研究结果的更广泛的规范和政策影响的系统考虑。为了最大限度地发挥我们研究的价值，我们将建立强有力的机制，将我们研究的经验和规范成果转化为政策和实践建议，并利用其他专家和主要利益攸关方群体的参与。着眼于ELSI研究的未来，我们将开发一个多学科的博士后培训计划，重点是培养ELSI研究的未来领导者，创造一个有利于跨学科学习和研究的环境，并借鉴优秀的导师和教师。总之，我们将创建一个结构，建立在我们现有的优势和成就，以加强跨学科合作，促进创新研究的进行，并促进教师和学员之间的智力增长。